Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma

Lee, Mee-Young; Lee, Nam-Hun; Jung, Da-Young; Lee, Jin-Ah; Seo, Chang‐Seob; Lee, Hoyoung; Kim, Jung-Hoon; Shin, Hyeun‐Kyoo

doi:10.1016/j.intimp.2010.01.008

Cited by 59 publications

(43 citation statements)

References 13 publications

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“…The inflammatory response to allergens in the asthmatic lung is a consequence of infiltration of the airway wall by inflammatory cells, especially eosinophils and is associated with the increased expression of several inflammatory proteins in lung tissue, including cytokines, such as IL-4 [21]. The resolution of inflammation is an essential process for the establishment of appropriate host responses and the return to homeostasis [22].…”

Section: Discussionmentioning

confidence: 99%

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Costa

Carneiro

Cerqueira-Lima

et al. 2012

International Immunopharmacology

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Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) is a plant widely used in Brazilian folk medicine to treat inflammatory disorders, such as asthma. In the present study we evaluated the immunomodulatory effects of Og and rosmarinic acid (RA, a polyphenolic compound) in a murine model of respiratory allergy induced by the Blomia tropicalis (Bt) mite. The respiratory allergy was induced in A/J mice by administration of Bt extract and the treatment was done using 25, 50 or 100mg/kg of an Og methanolic extract or using 2, 20 or 200mg/kg of RA. We then evaluated the changes induced by these drugs on immunological parameters related to the allergic process, which are up-regulated in this allergic model. The treatment of animals with 100mg/Kg Og and 200mg/Kg RA led to a significant reduction in the numbers of leukocytes/eosinophils in bronchoalveolar lavage (BAL); eosinophil peroxidase activity in BAL; presence of mucus in respiratory tract, histopathological changes in the lung, and IL-4 in BAL. These results suggest that the methanolic extract of Og and the polyphenol RA have therapeutic potential in this murine model of respiratory allergy to a clinically relevant human sensitizer allergen.

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Section: Discussionmentioning

confidence: 99%

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Costa

Carneiro

Cerqueira-Lima

et al. 2012

International Immunopharmacology

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“…The proton decoupled 13 C-NMR with the aid of DEPT-135 spectrum of compound 3 showed the presence of well resolved resonances of four carbon atoms, three of which turned out to be quaternary (δ 174.0 (C-1), 157.9 (C-2) and 157.3 (C-4)) and one was a methine carbon signal (δ 62.8 (C-3)). Compound 3is known to possess anti-inflammatory, anti-asthmatic and wound healing properties [15,16].…”

Section: Resultsmentioning

confidence: 99%

Analysis of the husk and kernel of the seeds of Moringa stenopetala

Melaku¹,

Arnold²,

Schmidt³

et al. 2017

Bull. Chem. Soc. Eth.

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ABSTRACT. The ethanol extract of the kernel of the endemic plant Moringa stenopetala after silica gel column chromatography led to the isolation of 4-(α-L-rhamnopyranosyloxy)benzyl glucosinolate (1) and sucrose. The oil obtained by Soxhlet extraction with petrol was trans-esterified with BF3-MeOH and analyzed by GC-MS. The results showed the presence of diverse fatty acids namely palmitic (11%), palmitoleic (1.2%), stearic (11%), oleic (63%), linoleic (1.2%), arachidic (6%) and the rare behenic acids (6%). The white glossy seed husk which comprises 25% of the whole seed yielded two compounds namely 4-(σ-L-rhamnosyloxy)benzyl alcohol (2) and allantoin (3). To the best of our knowledge this is the first report of compound 2 as a natural product. Allantoin is reported here for the first time from the genus Moringa.

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“…Allantoin is the main active compound in yam and has been reported to have antidiabetic effects with plasma glucose-lowing action and glucose uptake-enhancing action in muscle tissue [11,18,40]. Under diabetic conditions including insulin resistance, hyperglycemia is a risk factor for age-related loss of muscle mass in sarcopenia, which induces muscle synthesis reduction, chronic inflammation, and mitochondrial dysfunction [41].…”

Section: Discussionmentioning

confidence: 99%

“…Yam contains various compounds such as dioscin [15], steroidal saponins [15,16], saponins, gallic acid, vanillic acid [13], allatoin [11], and protodioscin [17]. Allantoin, a diureide of glyoxylic acid, is an active and abundant component of yam [9,11,18]. In vivo studies have shown allantoin to have anti-asthmatic [18], anti-diabetic [11,19] and anti-hypertensive [20] activities, as well as memory-enhancing effects in Alzheimer's disease [21].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Rhizome Extract of <em>Dioscorea Batatas </em>and Its Active Compound, Allantoin, on the Regulation of Myoblast Differentiation and Mitochondrial Biogenesis in C2C12 Myotubes

Nan¹,

Kang²,

Park³

et al. 2018

Preprint

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The present study was conducted to investigate the effects of rhizome extract of Dioscorea batatas (Dioscoreae Rhizoma, Chinese Yam) and its bioactive compound, allantoin, on myoblast differentiation and mitochondrial biogenesis in skeletal muscle cells. Yams were extracted in water and the extract was analyzed by HPLC. The expression of C2C12 myotubes differentiation and mitochondrial biogenesis regulators were determined by reverse transcriptase (RT)-PCR or Western blot. The glucose levels and total ATP contents were determined by glucose consumption, glucose uptake and ATP assays, respectively.

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Protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine model of asthma

Cited by 59 publications

References 13 publications

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Ocimum gratissimum Linn. and rosmarinic acid, attenuate eosinophilic airway inflammation in an experimental model of respiratory allergy to Blomia tropicalis

Analysis of the husk and kernel of the seeds of Moringa stenopetala

Effects of Rhizome Extract of <em>Dioscorea Batatas </em>and Its Active Compound, Allantoin, on the Regulation of Myoblast Differentiation and Mitochondrial Biogenesis in C2C12 Myotubes

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