Protective effects of Acanthopanax polysaccharides on cerebral ischemia–reperfusion injury and its mechanisms

Xie, Yunliang; Zhang, Bo; Zhang, Yingjie

doi:10.1016/j.ijbiomac.2014.09.055

Cited by 36 publications

(15 citation statements)

References 30 publications

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“…Acanthopanax polysaccharides are extracted from the root of Acanthopanax senticosus . They are comprised of chiisanoside, eleutheroside, saponin, senticoside, syringin, triterpenic and flavone compounds [200]. They have been reported to possess a wide variety of effects like anti-histaminic, antioxidant, anti-stress, hypolipidemic, immunomodulatory and sedative [201, 202].…”

Section: Neuroprotective Role Of Various Natural Products In Differenmentioning

confidence: 99%

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

et al. 2019

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Nature has bestowed mankind with surplus resources (natural products) on land and water. Natural products have significant role in prevention of disease and boosting of health in humans and animals. These natural products have been experimentally documented to possess various biological properties such as antioxidant, anti-inflammatory and anti-apoptotic activities. In vitro and in vivo studies have further established the usefulness of natural products in various preclinical models of neurodegenerative disorders. Natural products include phytoconstituents, like polyphenolic antioxidants, found in herbs, fruits, nuts, vegetables and also in marine and fresh water flora. These phytoconstituents may potentially suppress neurodegeneration and improve memory as well as cognitive functions of the brain. Also, they are known to play a pivotal role in prevention and cure of different neurodegenerative diseases, such as Alzheimer's disease, epilepsy, Parkinson's disease and other neuronal disorders. The large scale neuro-pharmacological activities of natural products have been documented which is due to be the result of either inhibition of inflammatory processes, or the up-regulation of various cell survival proteins or combination of both. Due to the scarcity of human studies on neuroprotective effects of natural products, this review focuses on the various established activities of natural products in in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications using the available knowledge in the literature.

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Section: Neuroprotective Role Of Various Natural Products In Differenmentioning

confidence: 99%

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

et al. 2019

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“…Acanthopanax senticosus , which belongs to the Araliaceae family, is a well‐known traditional Chinese medicine that possesses many pharmacological properties, such as antibacterial, anti‐fatigue, antioxidant, and antitumor properties (Li et al, ). Polysaccharide is a main compound of A. senticosus , and it exerts vital pharmacological effects, including immunomodulatory, antioxidant, and protective effects in cerebral ischemia–reperfusion injury (Xie et al, ); ameliorative effects in fulminant hepatic failure (Han et al, ); inhibitory effects on inflammatory cytokines; and antidiabetic effects (Xie, Zhang, & Zhang, ). However, the protective effects and mechanism of A. senticosus polysaccharide (ASPS) on the proliferation and differentiation of ISCs under stress conditions are not clear.…”

Section: Introductionmentioning

confidence: 99%

Acanthopanax senticosus polysaccharide regulates the intestinal homeostasis disruption induced by toxic chemicals in Drosophila

Zhang

Wang

Jin

2019

Phytotherapy Research

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The intestinal epithelium provides the first line of defense against pathogens and toxic compounds. The ingestion of toxic compounds causes an enhanced epithelial cell death and an excessive proliferation of intestinal stem cells, eventually resulting in the disruption of gut homeostasis. In this study, Drosophila gut inflammation model induced by toxic compounds was exploited to analyze the ameliorative effect of Acanthopanax senticosus polysaccharide on the disruption of gut homeostasis. As a result, it was found that A. senticosus polysaccharide can significantly increase the survival rate of Drosophila adults as well as reduce the excessive proliferation and differentiation of intestinal stem cells through epidermal growth factor receptor, jun-Nterminal kinase, and Notch signaling pathways under the exposure to toxic compounds dextran sodium sulfate. Moreover, the polysaccharide effectively decreased the epithelial cell death and the accumulation of reactive oxygen species and antimicrobial peptides induced by sodium dodecyl sulfate. In addition, it was found that A. senticosus polysaccharide can extend the lifespan of only female flies but not male flies. In conclusion, A. senticosus polysaccharide has an obvious protective effect on the gut homeostasis of Drosophila melanogaster.

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“…This improved outcome is consistent with the results of Mohibbullah et al [21], who also demonstrated that P. yezoensis exhibits a neuroprotective activity via inhibition of free radical generation and apoptosis due to the presence of polysaccharides with free radical scavenging activities. Moreover, numerous polysaccharides from different plant sources have also been shown to significantly reduce the neurological deficit score and infarct volume by inhibiting oxidative stress and inflammatory cytokines [13,14]. No evidence of neural deficits or infarct area in shamoperated control rats were observed as they were not occluded.…”

Section: Cerebral Infarct Volume/area In Iri and Ppy+iri Ratsmentioning

confidence: 99%

“…It also shows hepatoprotective and cardioprotective activities [11,12]. Furthermore, various polysaccharides from plants/marine algae have been shown to exhibit neuroprotective activity in a cerebral IR model [13,14]. However, the neuroprotective effect of PPY against IRI has not been explored so far.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of polysaccharides extracted from Porphyra yezoensis in rats with cerebral ischemia/reperfusion injury

Sun¹,

Wu²,

Chen³

et al. 2018

ARCH BIOL SCI BELGRA

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The polysaccharides of Porphyra yezoensis (PPY), porphyrans, are recognized as the major active components as they have several biological properties. This study was performed to assess the effect of PPY administration against cerebral ischemia-reperfusion injury (IRI). Thirty-two adult Sprague-Dawley (SD) rats were chosen and divided into 4 groups as follows: group I-rats received only saline; group II-subjected to middle cerebral artery occlusion (MCAO) for 60 min followed by 24 h of reperfusion (IRI-induced); group III-pretreated with PPY (100 mg/kg) for 7 days, followed by IRI induction; group IV-treated with PPY (100 mg/kg) for 7 days without IRI induction. All the data were analyzed by Dunnett's (multiple comparisons) test using SPSS software. Pretreatment with PPY significantly (p<0.01) lowered the neurological deficit and cerebral infarct volume in comparison with IRI-induced rats. A pronounced (p<0.01) increase in the levels of antioxidant components (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH)) was observed in PPY-supplemented rats. Also, the proinflammatory markers: interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and the nuclear factor-kappa B protein, subunit p65 (NF-κB p65) were substantially (p<0.01) suppressed in PPY-administered rats. Moreover, the protein levels of TNF-α and NF-κB p65 were considerably (p<0.01) downregulated upon pretreatment with PPY. Our data suggest that PPY could exhibit neuroprotective activity by attenuating oxidative stress and the inflammatory response.

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Protective effects of Acanthopanax polysaccharides on cerebral ischemia–reperfusion injury and its mechanisms

Cited by 36 publications

References 30 publications

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

Neuroprotective Strategies for Neurological Disorders by Natural Products: An update

Acanthopanax senticosus polysaccharide regulates the intestinal homeostasis disruption induced by toxic chemicals in Drosophila

Therapeutic effects of polysaccharides extracted from Porphyra yezoensis in rats with cerebral ischemia/reperfusion injury

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