Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat

Figueira, Maria Eduardo; Oliveira, Mónica Duarte; Direito, Rosa; Rocha, José Antonio; Alves, Paula; Serra, Ana Teresa; Duarte, Catarina M.M.; Bronze, Rosário; Fernandes, Adelaide; Brites, Dora; Freitas, Marisa; Fernandes, Eduarda; Sepodes, Bruno

doi:10.1016/j.biopha.2016.08.040

Cited by 35 publications

(22 citation statements)

References 47 publications

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“…In our study, 12 weeks of strawberry supplementation resulted in a significant decrease in IL-6, IL-1β, and MMP-3 in obese participants with knee OA, consistent with anti-inflammatory effects of dietary berries in OA management. These clinical observations are consistent with data showing that blueberry and raspberry extracts lower pain, inflammation, and edema, and articular destruction in experimental arthritis [ 21 , 22 ]. Metalloproteinases zinc-dependent enzymes (MMPs) play a key role in extracellular matrix remodeling and cartilage metabolism in knee OA.…”

Section: Discussionsupporting

confidence: 91%

“…Among the nutritional supplements and foods containing bioactive compounds, polyphenol-rich dietary berries have been extensively studied for their protective associations with other chronic conditions, including hypertension [ 18 ], type 2 diabetes [ 19 ], and overall inflammation [ 20 ], as reported in epidemiological studies. Berries, such as blueberries and red raspberries, have been shown to reduce the symptoms and progression of arthritis, such as pain and articular degeneration, in collagen-induced experimental models of arthritis [ 21 , 22 ]. Our group has previously reported the safety and efficacy of berries, especially freeze-dried blueberries and strawberries, in improving features of the metabolic syndrome and decreasing surrogate biomarkers of atherosclerosis in clinical studies [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis

et al. 2017

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Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee. In a randomized, double-blind cross-over trial, adults with radiographic evidence of knee OA (n = 17; body mass index (BMI): (mean ± SD) 39.1 ± 1.5; age (years): 57 ± 7) were randomized to a reconstituted freeze-dried strawberry beverage (50 g/day) or control beverage daily, each for 12 weeks, separated by a 2-week washout phase (total duration, 26 weeks). Blood draws and assessments of pain and quality of life indicators were conducted using the Visual Analog Scale for Pain (VAS Pain), Measures of Intermittent and Constant Osteoarthritis Pain (ICOAP), and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires, which were completed at baseline and at weeks 12, 14, and 26 of the study. Among the serum biomarkers of inflammation and cartilage degradation, interleukin (IL)-6, IL-1β, and matrix metalloproteinase (MMP)-3 were significantly decreased after strawberry vs. control treatment (all p < 0.05). Strawberry supplementation also significantly reduced constant, intermittent, and total pain as evaluated by the ICOAP questionnaire as well as the HAQ-DI scores (all p < 0.05). No effects of treatment were noted on serum C-reactive protein (CRP), nitrite, glucose, and lipid profiles. Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee OA.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis

et al. 2017

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“…Tea drinking is also associated with beneficial effects in maintaining bone density in old women and in menopausal women (77,78). Other data show that green tea polyphenols mitigate bone loss of female rats with chronic inflammation (79), and blueberry extracts have protective effects in acute inflammation and collagen-induced arthritis in the rats (80). Interesting is the protective effect of dietary supplementation of Hypericum perforatum against the oxidative stress and the bone mass loss obtained in rats subjected to forced swimming, in this case it has been shown how antioxidants can induce beneficial effects when oxidative stress and active bone resorption is caused by excessive physical activity (81).…”

Section: Role Of Nutrients Containing Antioxidants In Treatment and Pmentioning

confidence: 98%

Oxidative stress in bone remodeling: role of antioxidants

Domazetovic

Marcucci

Iantomasi

et al. 2017

ccmbm

545

524

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SummaryROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants. The natural antioxidants are: thiol compounds among which GSH is the most representative, and non-thiol compounds such as polyphenols, vitamins and also various enzymes. Many diseases have been linked to oxidative stress including bone diseases among which one of the most important is the osteoporosis. The redox state changes are also related to the bone remodeling process which allows the continuous bone regeneration through the coordinated action of bone cells: osteoclasts, osteoblasts and osteocytes. Changes in ROS and/or antioxidant systems seem to be involved in the pathogenesis of bone loss. ROS induce the apoptosis of osteoblasts and osteocytes, and this favours osteoclastogenesis and inhibits the mineralization and osteogenesis. Excessive osteocyte apoptosis correlates with oxidative stress causing an imbalance in favor of osteoclastogenesis which leads to increased turnover of bone remodeling and bone loss. Antioxidants either directly or by counteracting the action of oxidants contribute to activate the differentiation of osteoblasts, mineralization process and the reduction of osteoclast activity. In fact, a marked decrease in plasma antioxidants was found in aged or osteoporotic women. Some evidence shows a link among nutrients, antioxidant intake and bone health. Recent data demonstrate the antioxidant properties of various nutrients and their influence on bone metabolism. Polyphenols and anthocyanins are the most abundant antioxidants in the diet, and nutritional approaches to antioxidant strategies, in animals or selected groups of patients with osteoporosis or inflammatory bone diseases, suggest the antioxidant use in anti-resorptive therapies for the treatment and prevention of bone loss.

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“…These results were confirmed by several in vivo studies. Briefly, BB was shown to own anti-oxidant as well as anti-inflammatory properties, to induce neuroprotective mechanisms when supplemented to high fat diet fed mice [22][23][24][25], and to counteract acute inflammation in rats [26]. Several clinical trials have demonstrated the benefits of a blueberry-enriched diet.…”

Section: Introductionmentioning

confidence: 99%

Blueberry Counteracts BV-2 Microglia Morphological and Functional Switch after LPS Challenge

et al. 2020

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Microglia, the innate immune cells of the CNS, respond to brain injury by activating and modifying their morphology. Our study arises from the great interest that has been focused on blueberry (BB) for the antioxidant and pharmacological properties displayed by its components. We analyzed the influence of hydroalcoholic BB extract in resting or lipopolysaccharide (LPS)-stimulated microglia BV-2 cells. BB exerted a protective effect against LPS-induced cytotoxicity, as indicated by cell viability. BB was also able to influence the actin cytoskeleton organization, to recover the control phenotype after LPS insult, and also to reduce LPS-driven migration. We evaluated the activity of Rho and Rac1 GTPases, which regulate both actin cytoskeletal organization and migratory capacity. LPS caused an increase in Rac1 activity, which was counteracted by BB extract. Furthermore, we demonstrated that, in the presence of BB, mRNA expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α decreased, as did the immunofluorescence signal of iNOS, whereas that of Arg-1 was increased. Taken together, our results show that, during the inflammatory response, BB extract shifts the M1 polarization towards the M2 phenotype through an actin cytoskeletal rearrangement. Based on that, we might consider BB as a nutraceutical with anti-inflammatory activities.

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Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat

Cited by 35 publications

References 47 publications

Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis

Strawberries Improve Pain and Inflammation in Obese Adults with Radiographic Evidence of Knee Osteoarthritis

Oxidative stress in bone remodeling: role of antioxidants

Blueberry Counteracts BV-2 Microglia Morphological and Functional Switch after LPS Challenge

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