Protective effects of 4‐geranyloxy‐2,6‐dihydroxybenzophenonel on <scp>DSS</scp>‐induced ulcerative colitis in mice via regulation of <scp>cAMP</scp>/<scp>PKA</scp>/<scp>CREB</scp> and <scp>NF‐κB</scp> signaling pathways

Wang, Mingqiang; Li, Yanzhen; Su, Jingyong; Bai, Jing-Yan; Zhao, Zhongxiang; Sun, Zhang‐Hua

doi:10.1002/ptr.7689

Cited by 4 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, benzophenone derivatives have also been shown to be important in the anti-inflammatory effects of H. sampsonii . Recently, our group investigated the therapeutic effect and potential mechanisms of 4-geranyloxy-2,6-dihydroxybenzophenonel (4-GDB, 133 ) on DSS-induced ulcerative colitis in mice ( Wang et al, 2023 ). This study showed that intragastric administration of 4-GDB (20 mg/kg/day) for 8 days significantly attenuated colonic injury, reduced the expression of inflammatory mediators, and improved colonic barrier function in mice with colitis.…”

Section: Biological Activitiesmentioning

confidence: 99%

Hypericum sampsonii Hance: a review of its botany, traditional uses, phytochemistry, biological activity, and safety

Sun,

Li,

Zhong

et al. 2023

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Ethnopharmacological relevance: Hypericum sampsonii Hance, also known as Yuanbao Cao in Chinese, is a traditional medicinal herb from the Guttiferae family and has been widely used in China to treat various conditions, including dysentery, enteritis, mastitis, scrofula, and contusion.Aim of the review: This review aims to provide a comprehensive overview of the botany, traditional uses, phytochemistry, biological activity and safety of H. sampsonii and to highlight its potential for medical application and drug development.Materials and methods: We searched several databases, i.e., Web of Science, SciFinder, PubMed, CBM, CNKI, Google Scholar, etc., for relevant information on H. sampsonii. Additionally, we also consulted some books on Chinese medicine.Results: To date, 227 secondary metabolites have been isolated from H. sampsonii, including polycyclic polyprenylated acylphloroglucinols (PPAPs), benzophenones, xanthones, flavonoids, naphthodianthrones, anthraquinones and aromatic compounds. These metabolites exhibit various biological activities such as anti-inflammatory, anti-tumor, anti-depressant, anti-oxidant, anti-viral and anti-bacterial effects. PPAPs are considered the main active metabolites with rich biological activities. Despite being known as rich source of PPAPs, the full extent of H. sampsonii biological activities, including their potential as PDE4 inhibitors, remained unclear. Since, previous studies have mainly been based on structural identification of metabolites in H. sampsonii, and efficacy evaluations of these metabolites based on clinical applications of H. sampsonii lack sufficient data. However, current evidence suggest that PPAPs are the most likely material basis for efficacy. From the limited information available so far, there is no evidence of potential safety issues and the safety data are limited.Conclusion: Collectively, this review provides a comprehensive overview of the botany, traditional uses, phytochemistry, pharmacology, and safety of H. sampsonii, a valuable medicinal plant in China with various pharmacological activities. Based on pharmacological studies, H. sampsonii shows potential for treating gastrointestinal and gynecological disorders as well as traumatic injuries, which aligns with traditional medicinal use due to the presence of PPAPs, benzophenones, xanthones, and flavonoids. Therefore, further studies are needed to evaluate the pharmacological effects and elucidate the pharmacological mechanisms. In addition, pharmacological mechanisms and safety evaluation of PPAPs on animal models need to be clarified. Yet, further comprehensive studies are required to elucidate the phytochemical constituents, pharmacological mechanisms, structure-activity relationships, safety evaluation, and quality standards of this plant. Takentogether, this review highlights the potential of H. sampsonii for medical application and drug development.

show abstract

Section: Biological Activitiesmentioning

confidence: 99%

Hypericum sampsonii Hance: a review of its botany, traditional uses, phytochemistry, biological activity, and safety

Sun,

Li,

Zhong

et al. 2023

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

Hypersampsonone H attenuates ulcerative colitis via inhibition of PDE4 and regulation of cAMP/PKA/CREB signaling pathway

Li,

Wang,

et al. 2024

International Immunopharmacology

View full text Add to dashboard Cite

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Bai,

Wang,

et al. 2024

Science Progress

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence, such as Crohn's disease and ulcerative colitis. The accurate etiology and pathogenesis of IBD remain unclear, and it is generally believed that it is related to genetic susceptibility, gut microbiota, environmental factors, immunological abnormalities, and potentially other factors. Currently, the mainstream therapeutic drugs are amino salicylic acid agents, corticosteroids, immunomodulators, and biological agents, but the remission rates do not surpass 30–60% of patients in a real-life setting. As a consequence, there are many studies focusing on emerging drugs and bioactive ingredients that have higher efficacy and long-term safety for achieving complete deep healing. This article begins with a review of the latest, systematic, and credible summaries of the pathogenesis of IBD. In addition, we provide a summary of the current treatments and drugs for IBD. Finally, we focus on the therapeutic effects of emerging drugs such as microRNAs and lncRNAs, nanoparticles-mediated drugs and natural products on IBD and their mechanisms of action.

show abstract

Protective effects of 4‐geranyloxy‐2,6‐dihydroxybenzophenonel on DSS‐induced ulcerative colitis in mice via regulation of cAMP/PKA/CREB and NF‐κB signaling pathways

Cited by 4 publications

References 49 publications

Hypericum sampsonii Hance: a review of its botany, traditional uses, phytochemistry, biological activity, and safety

Hypericum sampsonii Hance: a review of its botany, traditional uses, phytochemistry, biological activity, and safety

Hypersampsonone H attenuates ulcerative colitis via inhibition of PDE4 and regulation of cAMP/PKA/CREB signaling pathway

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Contact Info

Product

Resources

About