Protective effects and mechanisms of bilirubin nanomedicine against acute pancreatitis

Yao, Qing; Jiang, Xue; Zhai, Yuanyuan; Luo, Lan-Zi; Xu, He‐Lin; Xiao, Jian; Kou, Longfa; Zhao, Ying‐Zheng

doi:10.1016/j.jconrel.2020.03.034

Cited by 51 publications

(36 citation statements)

References 37 publications

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“…Biliverdin, as one main component in the BVSF hydrogel system, also contributed to the wound repair. Our previous research indicated that bilirubin possesses a power anti-inflammatory property, which showed significant cytoprotective effects against oxidative and inflammatory damage in multiple cell lines 40 , 63 - 65 . Biliverdin, as a precursor substance of bilirubin, has also been demonstrated as an important cytoprotective and anti-inflammatory molecule 34 , 35 .…”

Section: Resultsmentioning

confidence: 99%

Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

et al. 2020

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Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might damage the adjacent tissue due to the leakage of the photoabsorbers and the residual materials after treatment might hinder the local healing process. A bifunctional hydrogel that holds both photothermal property and potent pro-healing ability provides a viable option to resolve this issue. Methods: In this study, we developed a bioinspired green hydrogel (BVSF) with the integration of bioproduct biliverdin into natural derived silk fibroin matrix for antiglioma photothermal therapy and wound healing. Results: The BVSF hydrogel possessed excellent and controllable photothermal activity under NIR irradiation and resulted in effective tumor ablation both in vitro and in vivo. Additionally, the BVSF hydrogel exerted anti-inflammatory effects both in vitro and in vivo, and stimulated angiogenesis and wound healing in a full-thickness defect rat model. Conclusion: Overall, this proof-of-concept study was aimed to determine the feasibility and reliability of using an all-natural green formulation for photothermal therapy and post-treatment care.

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Section: Resultsmentioning

confidence: 99%

Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

et al. 2020

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“…[247] Therefore, Yao et al prepared bilirubin-encapsulated SF nanoparticles (BRSNPs) by cross-linking and self-assembly to study the protective effect and mechanism of bilirubin nanodrugs on AP (Figure 7c). [248] In the AP model, BRSNPs had a strong therapeutic effect by reducing oxidative stress, reducing the expression of pro-inflammatory cytokines, and inhibiting the recruitment of macrophages and neutrophils. The mechanism study showed that BRSNPs protected acinar cells by scavenging ROS, inhibiting oxidative damage and the inflammatory NF-B pathway, and activating the Nrf2/HO-1 pathway.…”

Section: Nanocatalystsmentioning

confidence: 99%

“…Adapted with permission. [ 248 ] Copyright 2020, Elsevier. d) Photodriven NR and mechanisms of its photosynthesis of H 2 gas in situ to reduce the overproduction of oxidative stress in LPS‐induced inflamed paw created in a mouse model.…”

Section: Applications In Nanomedicinementioning

confidence: 99%

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Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Zhao

Zhang

Yang

et al. 2020

Adv Healthcare Materials

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With the rapid advancements in nanotechnology and materials science, numerous nanomaterials have been used as catalysts for nanomedical applications. Their design and modification according to the microenvironment of diseases have been shown to achieve effective treatment. Chemists are in pursuit of nanocatalysts that are more efficient, controllable, and less toxic by developing innovative synthetic technologies and improving existing ones. Recently, single-atom catalysts (SACs) with excellent catalytic activity and high selectivity have attracted increasing attention because of their accurate design as nanomaterials at the atomic level, thereby highlighting their potential for nanomedical applications. In this review, the recent advances in nanocatalysts and SACs are briefly summarized according to their synthesis, characterizations, catalytic mechanisms, and nanomedical applications. The opportunities and future scope for their development and the issues and challenges for their application as nanomedicine are also discussed. As far as it is known, the review is the systematic comparison of nanocatalysts and SACs, especially in the field of nanomedicine, which has promoted the development of nanocatalytic medicine.

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“…Nano-drug delivery systems (NDDS) have attracted a lot of attention in recent years due to their unique characteristics, including increased drug solubility and stability, sustained drug release, prolonged life in circulation, reduced toxicity, and enhanced therapeutic efficacy [ 1 , 2 , 3 ]. The marked progress in the development of biomaterials and novel nanotechnology strategies has added further fuel to the advancement in the field [ 4 , 5 , 6 , 7 , 8 ]. The results have been encouraging, with several drugs in nano-formulations already in use in the clinics (e.g., Lipusu, Doxil, Abraxane, and Genexol-PM).…”

Section: Introductionmentioning

confidence: 99%

Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery

Kou

Yao

Zhang

et al. 2020

Cancers

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Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood–brain barrier, and blood–retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of nutrients. Similarly, selective transporters are also overexpressed in the plasma membrane of specific cell types under pathological states to meet the biological needs demanded by such conditions. Nano-drug delivery systems could be strategically modified to make them recognizable by these transporters to enhance the transfer of drugs across the biological barriers or to selectively expose specific cell types to therapeutic drugs. Here, we provide a comprehensive review and detailed evaluation of the recent advances in the field of transporter-targeted nano-drug delivery systems. We specifically focus on areas related to intestinal absorption, transfer across blood–brain barrier, tumor-cell selective targeting, ocular drug delivery, identification of the transporters appropriate for this purpose, and details of the rationale for the approach.

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Protective effects and mechanisms of bilirubin nanomedicine against acute pancreatitis

Cited by 51 publications

References 37 publications

Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery

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