Protective Effectiveness of Hantavirus Vaccine

Park, Keeho; Kim, Chang Soo; Moon, Ki Tae

doi:10.3201/eid1012.040684

Cited by 48 publications

(27 citation statements)

References 7 publications

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“…the hantavirus vaccine is questionable. 10,11 But it is impossible to conclude that the vaccinations are not associated with the severity of HFRS because (1) the sample size of this study might be small to find a benefit of vaccination on the severity of HFRS and (2) selection bias might exist; asymptomatic or mild HFRS cases might not be included.…”

Section: Discussionmentioning

confidence: 87%

Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus

Kim

Lee

Kim

et al. 2007

Journal of Infection

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Section: Discussionmentioning

confidence: 87%

Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus

Kim

Lee

Kim

et al. 2007

Journal of Infection

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“…The viruses are transmitted to humans by the inhalation of excreta of rodents infected with hantaviruses (3). HFRS was first recognized during the Korean War in the early 1950s, and although a hantavirus vaccine has been developed, the disease remains a serious problem in Asia and Europe (1, 4), and especially among soldiers in Korea (5, 6). A 2006 report describes HFRS epidemiology in endemic regions in Korea during a relatively short period, 1995-1998 (7); however, an updated epidemiological study is necessary to better understand the current status of HFRS in Korea.…”

mentioning

confidence: 99%

Epidemiology of Hemorrhagic Fever with Renal Syndrome in Korea, 2001-2010

et al. 2013

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This study describes the epidemiology of hemorrhagic fever with renal syndrome (HFRS) in the past 10 yr (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) in Korea. During this period, a total of 3,953 HFRS patients and an average prevalence rate of 0.81 per 100,000 population were recorded, with a total of 40 fatal cases, corresponding to a case fatality rate of 1.01%. More HFRS cases were found in men than in women (57% vs 43%), and a higher prevalence rate of HFRS was observed in patients older than 40 yr (82.1%). The highest numbers of HFRS cases were found amongst farmers (35.6%). The majority of HFRS cases (71.3%) occurred in the last quarter of the calendar year (October to December). More HFRS cases occurred in the western part than in the eastern part of Korea (68.9% vs 31.1%). The incidence of HFRS was significantly higher (P < 0.001) in rural areas than in urban areas (80.3% vs 19.7%). HFRS still occurs commonly among men, in autumn, and in western rural area of Korea. http://dx.doi.org/10. 3346/jkms.2013.28.10.1552 • J Korean Med Sci 2013 28: 1552-1554 BRIEF COMMUNICATION Infectious Diseases, Microbiology & ParasitologyHantavirus infection induces 2 different diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), mainly in Korea, far east Russia, and China and in the United States, respectively (1, 2). The viruses are transmitted to humans by the inhalation of excreta of rodents infected with hantaviruses (3). HFRS was first recognized during the Korean War in the early 1950s, and although a hantavirus vaccine has been developed, the disease remains a serious problem in Asia and Europe (1, 4), and especially among soldiers in Korea (5, 6). A 2006 report describes HFRS epidemiology in endemic regions in Korea during a relatively short period, 1995-1998 (7); however, an updated epidemiological study is necessary to better understand the current status of HFRS in Korea. This study provides a comprehensive epidemiological overview of HFRS during the past decade in Korea.Raw data were utilized from the National Notifiable Disease Surveillance System (NNDSS) website of the Korean Center for (Table 1). The prevalence rate (PR) of HFRS per 100,000 population and case fatality rate (CFR) were estimated by the criteria established by the World Health Organization (WHO), and the upper and lower limits of the 95% confidence interval (CI) were calculated. Statistically significant differences between the epidemiological aspects were determined at P < 0.05 and P < 0.01 using the chi-square test or the paired t-test. The data analyses were carried out using the statistical system software included in Microsoft Excel 2007.As shown in Table 1, the HFRS cases were analyzed according to the PR, CFR, gender, age, and occupation of the infected individuals. There were a total of 3,953 HFRS patients with an average PR of 0.81 (95% CI, 0.79-0.85) per 100,000 population and a total of 40 fatal cases with a CFR of 1.01% (95% CI, 0.7-1.3). A significantly higher number (P <...

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“…Several different vaccine strategies have been experimentally tested [72] and certain vaccine candidates have been tested in humans [73]. A suckling mouse brain-derived vaccine, Hantavax™, is available in Korea, and similar vaccines are also sold in China, however, as yet, there is no clear evidence that these vaccines protect against HFRS [74].…”

Section: Vaccines/therapeutics Currently Availablementioning

confidence: 99%