Protective effect of Zingerone, a dietary compound against radiation induced genetic damage and apoptosis in human lymphocytes

Rao, B. Nageshwar; Archana, P. R.; Aithal, Balkudru Kiran; Rao, Bola Sadashiva Satish

doi:10.1016/j.ejphar.2011.02.002

Cited by 60 publications

(27 citation statements)

References 58 publications

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“…Zingerone [4-(4-hydroxy-3-methoxyphenyl) butan-2-one] is a stable active component of dry ginger rhizome [19] and has been found to down regulate age related activation of proinflammatory enzymes [20]; protect human lymphocytes from radiation induced genetic damage and apoptosis [21] reduce endotoxin induced acute lung injury in mice [22]. To the best of our knowledge not many studies are available on its in vivo protective effect against hepatic inflammation induced by antibiotic mediated endotoxemia.…”

Section: Introductionmentioning

confidence: 99%

Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

2014

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Antibiotic-induced endotoxin release is associated with high mortality rate even when appropriate antibiotics are used for the treatment of severe infections in intensive care units. Since liver is involved in systemic clearance and detoxification of endotoxin hence it becomes a primary target organ for endotoxin mediated inflammation. Currently available anti-inflammatory drugs give rise to serious side effects. Hence, there is an urgent need for safe and effective anti-inflammatory therapy. It is likely that anti-inflammatory phytochemicals and neutraceutical agents may have the potential to reduce the endotoxin mediated inflammation and complications associated with endotoxin release. Keeping this in mind, the present study was planned to evaluate the hepatoprotective potential of zingerone (active compound of zingiber officinale) against liver inflammation induced by antibiotic mediated endotoxemia. The selected antibiotics capable of releasing high content of endotoxin were employed for their in vivo efficacy in P.aeruginosa peritonitis model. Released endotoxin induced inflammation and zingerone as co-anti-inflammatory therapy significantly reduced inflammatory response. Improved liver histology and reduced inflammatory markers MDA, RNI, MPO, tissue damage markers (AST, ALT, ALP) and inflammatory cytokines (MIP-2, IL-6 and TNF-α) were indicative of therapeutic potential of zingerone. The mechanism of action of zingerone may be related to significant inhibition of the mRNA expression of inflammatory markers (TLR4, RelA, NF-kB2, TNF- α, iNOS, COX-2) indicating that zingerone interferes with cell signalling pathway and suppresses hyper expression of cell signaling molecules of inflammatory pathway. Zingerone therapy significantly protected liver from endotoxin induced inflammatory damage by down regulating biochemical as well as molecular markers of inflammation. In conclusion, this study provides evidence that zingerone is a potent anti-inflammatory phytomedicine against hepatic inflammation induced by antibiotic mediated endotoxemia. These results thus suggest that zingerone treatment can be used as a co-therapy with antibiotics to reduced endotoxin induced inflammation during treatment of severe P.aeruginosa infections.

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Section: Introductionmentioning

confidence: 99%

Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

2014

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“…(25) . Referentes aos 19 estudos restantes foram abordadas as seguintes propriedades terapêuticas com pesquisas envolvendo o gengibre: tratamento da náusea induzida por quimioterapia (26) , função para absorção de Ferro, Zinco e Cálcio (27) , analgésico (28) , antidependência contra o uso crônico da morfina (29) , anti-inflamatório (30) , antimicrobiano (31) , combate à ação da artrite reumatoide (32) , aumento da proteólise muscular em patos (33) , tratamento do câncer de mama (14) , citoprotetor (15) , combate ao vírus sincicial respiratório humano (VSR) (34) , combate a sintomas da Doença de Alzheimer (35) , tratamento da fibrose hepática (36) , proteção contra a genotoxicidade (37) , inibição da enzima Angiotensina I (38) , inibição da motilidade do cólon (39) , atenuação da isquemia cerebral (40) , redução da nefrotoxicidade (41) e neuroprotetor (42) , as quais tiveram um estudo cada publicadas durante o período de análise.…”

Section: Resultsunclassified

Análise Sistemática Da Produção Científica Do Zingiber Officinale Roscoe Após a Criação Da Relação Nacional De Plantas Medicinais De Interesse Ao Sistema Único De Saúde

Marmitt¹,

Rempel²,

Goettert³

et al. 2015

ACS

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Arq. Ciênc. Saúde. 2015 out-dez; 22(4) xx-xx Análise sistemática da produção científica do Zingiber Officinale roscoe após a criação da relação nacional de plantas medicinais de interesse ao sistema único de saúde Descritores: Gengibre; Uso Terapêutico; Atenção Primária à Saúde. AbstractIntroduction: Ginger (Zingiber officinale Roscoe) is a native plant from Asia that has been used as a spice and medicinal compound for thousands of years. Many of its compounds have been isolated, identified, and studied due to their pharmacological effects. Objectives: Quantify clinical trials reporting some form of therapeutic action from the use of Z. officinale plant, which are listed on the National Medicinal Plants of Interest to the Unified Health System published between 2010 and 2013 in three scientific databases (SciELO, Science Direct and Springer). Material and Methods: We searched databases using the key search term "Zingiber officinale Roscoe." A total of 757 articles were retrieved. We selected the studies dealing specifically with the term "Zingiber officinale" or related terms such as "ginger," "gingerol," "gingerols," "ginger," and "ginger". Reading the Abstract, we selected those that reported some kind of therapeutic treatment. In the last phase, the selected articles were fully read to search those proving therapeutic potentials from the study of Z. officinale. Results: Thirty articles were included in this review. Six studies reported the antioxidant activity representing the most cited therapy. Conclusion: With the results, it is expected to be possible to guide further research on the species in question, including other diseases not yet explored.Descriptors: Ginger; Therapeutic Use; Primary Health Care.

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“…Vanilloid[3-methoxy-4-hydroxy benzene] group and hydroxyl (-OH) group in zingerone structure are mainly responsible for its potent antioxidant and anti-inflammatory activity. Workers have shown its protective effects in human lymphocytes against radiation induced damage (Rao et al, 2011). This makes zingerone a safe and potential candidate for treatment of P. aeruginosa infections but dosage and delivery methods needs to be standardized in vivo infection models.…”

Section: Discussionmentioning

confidence: 99%

“…1) is a major active component of dry ginger root. It not only has strong antiinflammatory activity (Sies and Masumoto, 1997), but also has protective efficacy in various in vivo models of inflammatory disorders (Rao et al, 2011). Recently, zingerone has also been shown to be effective in modulating the biofilm architecture, making P. aeruginosa biofilms more susceptible to ciprofloxacin (Kumar et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

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Structural alterations in Pseudomonas aeruginosa by zingerone contribute to enhanced susceptibility to antibiotics, serum and phagocytes

2014

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Protective effect of Zingerone, a dietary compound against radiation induced genetic damage and apoptosis in human lymphocytes

Cited by 60 publications

References 58 publications

Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

Análise Sistemática Da Produção Científica Do Zingiber Officinale Roscoe Após a Criação Da Relação Nacional De Plantas Medicinais De Interesse Ao Sistema Único De Saúde

Structural alterations in Pseudomonas aeruginosa by zingerone contribute to enhanced susceptibility to antibiotics, serum and phagocytes

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