Protective effect of wild <i>Corni fructus</i> methanolic extract against acute alcoholic liver injury in mice

Jiang, Zhihui; Wang, Jian; Xue, Huiting; Wang, Meng; Jiang, Hai; Yin-ku, Liang; Dias, Alberto Carlos Pires; Marslin, Gregory; Chen, Chen; Zhang, Xiaoying

doi:10.1080/13510002.2016.1239867

Cited by 21 publications

(15 citation statements)

References 24 publications

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“…The current research results show the hepatoprotective effect on polysaccharides against alcohol-induced liver injury by attenuating the expression of CYP2E1 and by enhancing the protective role of anti-oxidative defense system. Similar studies have previously shown that a wide range of natural products and their active substances have strong CYP2E1 inhibitory capacity [ 41 , 42 ]. In this experiment, En-OPS can increase the activities of ADH and ALDH and reduce CYP2E1 levels, indicating that En-OPS has a positive effect on alcohol metabolism.…”

Section: Discussionsupporting

confidence: 72%

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Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

et al. 2018

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This work was to examine the antioxidation in vitro and hepatoprotective effects of enzyme-extracted Oudemansiella radiata polysaccharides (En-OPS) on alcohol-induced liver damage in mice. The antioxidant activities were determined according to the scavenging effects of En-OPS on hydroxyl, superoxide, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, and the level of reducing power. En-OPS showed hepatoprotective activities on decreasing the serum levels of aspertate aminotransferase (AST), alamine aminotransferase (ALT), and alkaline phosphatase (ALP), as well as hepatic lipid levels of total cholesterol (TC) and triacylglycerols (TG). En-OPS treatment reversed the acute impairment induced by alcohol consumption, including reactive oxygen species (ROS) generation, malondialdehyde (MAD), and lipid peroxide (LPO) elevation; and superoxide dismutase (SOD), GSH peroxide (GSH-Px), catalase (CAT), and total antioxidant capacity (T-AOC) impairment. The En-OPS effectively ameliorated alcohol metabolism by activating alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and reducing cytochrome P450 2E1 (CYP2E1) levels. Furthermore, the histopathological observations also displayed that En-OPS could alleviate liver damage. These results indicated that En-OPS could be suitable to be an ingredient of preventing alcoholic liver diseases (ALD). In addition, the preliminary structure characteristics of En-OPS were also analyzed by Fourier transform infrared (FT-IR) spectroscopy and a gas chromatography-flame ionization detector (GC-FID).

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Section: Discussionsupporting

confidence: 72%

“…Gavage was processed with a syringe once daily and the entire experiment procedure lasted for 20 consecutive days. On the 21st day, all mice, except those in the NC group, were orally administered with 8 mL/kg of 50% alcohol solution every 6 h for four times to induce hepatic injury by the previous reports [ 42 , 53 ].…”

Section: Methodsmentioning

confidence: 99%

Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

et al. 2018

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“…GSH content was quantified according to the method of Moron, Depierre, and Mannervik () based on its reaction with 5,5′‐dithiobis‐(2‐nitrobenzoic‐acid). AHR activity was evaluated based on the Fenton reaction (Jiang et al, ). Soluble protein concentration of homogenates was determined by the method of Bradford () using bovine serum albumin as standard.…”

Section: Methodsmentioning

confidence: 99%

Effects of inorganic mercury exposure on histological structure, antioxidant status and immune response of immune organs in yellow catfish (Pelteobagrus fulvidraco)

Sun

Rao

et al. 2018

J of Applied Toxicology

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Mercury (Hg) is well recognized as a highly toxic substance to fish. Nevertheless, little is known about the toxic effects of Hg on immune organs. In this study, we investigated histology, antioxidant status and immune response of the spleen and head kidney in yellow catfish following 6 weeks of exposure to environmentally relevant concentrations of inorganic Hg (2 and 10 μg l Hg ). As expected, Hg accumulation and histological injury in both tissues were observed. Meanwhile, Hg exposure induced oxidative stress, which increased antioxidant enzyme (superoxide dismutase, catalase and glutathione peroxidase) activities, glutathione content, anti-hydroxyl radical capacity and the expression of genes associated with antioxidant (sod1, cat, gpx1, nrf2 and mt) and stress (hsp70) responses in dose- and tissue-specific manners. In the spleen, the mRNA levels of immune-related genes (il-1β, il-8, tnf-α, il-10, tgf-β, lys and c3) were upregulated by Hg exposure. However, in the head kidney, upregulation of tnf-α, il-10 and tgf-β mRNAs and downregulation of il-1β and lys expressions were observed, while transcriptions of il-8 and c3 were remarkably upregulated only in the 2 μg l group. Overall, our study indicated that Hg exposure could result in Hg accumulation and thereby induced histological impairment, oxidative stress and immunotoxicity in immune organs of yellow catfish, but some enzymes and/or genes involved in antioxidant and immune systems would be activated to resist Hg -induced damage.

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“…In total, 56 experimental mice were randomly assigned into 8 groups of 7 mice in each group (n=7). The reported protocol (Jiang et al, 2016) was exploited to modeling alcohol induced liver injury. Group 1 was the normal control group (NC group).…”

Section: Animal Experimentsmentioning

confidence: 99%

“…The microsomal preparation was conducted according to the method described by Jiang et al (2016), and the Bradford protein assay was used to estimate the protein content using bovine serum albumin as the standard (Tiangen Biotech, Beijing, China). Proteins were resolved by SDS-PAGE and transferred to PVDF membranes (Millipore Corporation, Boston, ME, USA).…”

Section: Western Blot Analysismentioning

confidence: 99%

Hepatoprotective effect of Alhagi sparsifolia against Alcoholic Liver injury in mice

Maimaitimin

Jiang

Aierken

et al. 2018

Braz. J. Pharm. Sci.

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Overconsumption of alcohol leads to alcoholic liver disease (ALD). Natural compounds have been investigated previously for their hepatoprotective activities against liver injury. This study investigated the protective effect of Alhagi sparsifolia on ALD. Alcohol was administered to mice for three consecutive days; either alone or in combination with Alhagi sparsifolia extract (150, 300, 600 mg/kg). Serum aspartate aminotransferase and alanine transaminase as biomarkers of liver injury, the content of malonaldehyde, hydrogen peroxide (H 2 O 2) and glutathione which indicated the redox status of liver and the antioxidant enzyme activity of super oxide dismutase were detected, respectively. Moreover, the expression of protein cytochrome P450 2E1 (CYP2E1) the key enzyme of alcohol metabolism, and also tested by western blot experiment. Subsequently, the mRNA levels of inflammatory factors including TNF-α and TLR4 was determined real-time PCR. Results showed that Alhagi sparsifolia significantly alleviated alcohol-induced liver injury by reducing serum ALT and AST, inhibiting MDA and H 2 O 2 content, increasing SOD, and GSH level in the liver (P< 0.05). In addition, the Alhagi sparsifolia treatment inhibited the expression of CYP2E1 (P< 0.05). The results suggest that Alhagi sparsifolia could be a promising natural substance for ameliorating acute alcohol-induced oxidative stress and hepatic injury.

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Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

Abstract: (2017) Protective effect of wild Cornifructus methanolic extract against acute alcoholic liver injury in mice, Redox Report, 22:6,[338][339][340][341][342][343][344][345]

Cited by 21 publications

References 24 publications

Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury

Effects of inorganic mercury exposure on histological structure, antioxidant status and immune response of immune organs in yellow catfish (Pelteobagrus fulvidraco)

Hepatoprotective effect of Alhagi sparsifolia against Alcoholic Liver injury in mice

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