Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo

Ismiyati, Atik; Wiyasa, I Wayan Arsana; Hidayati, Dwi Yuni Nur

doi:10.1155/2016/3134105

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…This study confirms that folliculogenesis can be influenced by xenobiotics, including DMPA 18,19 . Our study expands previous findings that monkeys treated with progestin would undergo apoptosis of ovarian epithelial cells relative to the control group and administration of ethinyl estradiol7 or changes in oxidative stress as the basic mechanisms of cellular apoptosis 20 .…”

Section: Discussionsupporting

confidence: 86%

Yeşil çay ve depot-medroxyprogesterone asetat infüzyonunun granüloza hücre sayısı ile ovaryan primer folikül sayı ve büyüklüğü üzerine kombine etkisi: dişi ratlarda in vivo çalışma

Maharani¹

2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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ARAŞTIRMA/RESEARCHCombined effects of infusion of green tea and depotmedroxyprogesterone acetate on the number of granulosa cells and the number and size of ovarian primary follicles: an in vivo study in female ratsYeşil çay ve depot-medroxyprogesterone asetat infüzyonunun granüloza hücre sayısı ile ovaryan primer folikül sayı ve büyüklüğü üzerine kombine etkisi: dişi ratlarda in vivo çalışma AbstractÖz Purpose: The purpose of the present study was to analyze the effects of green tea infusion on the toxicity of ovaries of female rats treated with the contraceptive depotmedroxyprogesterone acetate (DMPA). Material and Methods: A total of twenty-four female rats were randomly divided into four groups, incuding the control group (no treatment), the DMPA-treated group and the group treated with DMPA and infusion of green tea at various doses (165 and 330 mg/gram of body weight per day). The number of granulosa cells, the number of ovarian follicles and the size of ovarian follicles were subjected to histopathological analysis. Results: The number of granulosa cells did not differ significantly among the study groups. The number of ovarian follicles was significantly higher in the DMPAtreated group than that of the control group. Of doses of 165 and 330 mg/g of body weight of green tea administration, only the low dose decreased the number of ovarian follicles significantly relative to the DMPA-treated group, although it has not yet reached the levels comparable to those of the control group. The size of ovarian follicles did not differ significantly among the study groups. Conclusion: DMPA led to an increased number of ovarian follicles, which was restored by infusion of low doses of green tea. Thus, green tea constitutes an herb that can be combined with administration of DMPA and useful in inhibiting the adverse effects of contraceptives.

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Section: Discussionsupporting

confidence: 86%

Yeşil çay ve depot-medroxyprogesterone asetat infüzyonunun granüloza hücre sayısı ile ovaryan primer folikül sayı ve büyüklüğü üzerine kombine etkisi: dişi ratlarda in vivo çalışma

Maharani¹

2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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“…Although the antioxidant status and markers of oxidative stress were not assessed in this study, DMPA is known to induce ovarian oxidative stress [20]. A study to determine the protective effect of vitamins C and E on DMPA-induced ovarian oxidative stress in vivo, found elevated levels of malondialdehyde and reduced level of superoxide dismutase in DMPA users when compared to the control group [20].…”

Section: Interpretation Of Resultsmentioning

confidence: 86%

The Use of Hormonal Contraceptives and Preeclampsia among Ghanaian Pregnant Women

Asare¹,

Asare²,

Owiredu³

et al. 2021

OJOG

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“…It is evident that augmentation of the antioxidant defense mechanism has a protective role in renal ischemic tissue [22][23][24][25]. Vitamin C, a natural water-soluble antioxidant, has the potential to intervene in the development of cardiovascular disease by modulating redox steps [26]. Vitamin C could react rapidly with O 2 -to play an antioxidant role in cytosol and extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice

Zhu¹,

Zhang²,

Zhang³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. Methods: IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced glutathione (GSH), total reactive oxygen species (ROS) level and superoxide dismutase (SOD) were examined. Doppler was used to investigate renal arterial resistance. The isolated renal arterial rings served for hypoxia/reoxygenation analysis. Acetylcholine (ACh) and sodium nitroprusside (SNP)-induced relaxations of isolated renal arterial rings were exerted. Results: Vitamin C supplementation preserved kidney morphology and renal function following IRI. It was shown that pretreatment with vitamin C for mice subjected to IRI significantly elevated renal NO and GSH levels after reperfusion. Meanwhile, vitamin C administration decreased resistance index of renal artery and ameliorated oxidative stress secondary to IRI. The total ROS level in renal artery was decreased whereas the renal arterial SOD expression was increased by vitamin C supplementation following IRI. Pretreatment with vitamin C significantly potentiated the ACh and SNP-induced relaxations in both control and hypoxic renal arterial rings. Conclusion: Vitamin C protects kidney function and renal arterial reactivity against IRI. The protective role of vitamin C is linked to ROS, SOD, GSH and NO levels in renal ischemic injury.

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Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo

Cited by 9 publications

References 21 publications

Yeşil çay ve depot-medroxyprogesterone asetat infüzyonunun granüloza hücre sayısı ile ovaryan primer folikül sayı ve büyüklüğü üzerine kombine etkisi: dişi ratlarda in vivo çalışma

Yeşil çay ve depot-medroxyprogesterone asetat infüzyonunun granüloza hücre sayısı ile ovaryan primer folikül sayı ve büyüklüğü üzerine kombine etkisi: dişi ratlarda in vivo çalışma

The Use of Hormonal Contraceptives and Preeclampsia among Ghanaian Pregnant Women

Evaluation of Vitamin C Supplementation on Kidney Function and Vascular Reactivity Following Renal Ischemic Injury in Mice

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