Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin

Nassar, Seham Zakaria; Badae, Noha Mohamed

doi:10.1080/10641955.2019.1597108

Cited by 12 publications

(8 citation statements)

References 44 publications

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“…Recent studies have shown that in PCOS rats, the supplementation of VD 3 reduced the thickness of the endometrium and decreased the immunohistochemical staining of caspase-3 and proliferative marker Ki67 as well as the serum AMH level [ 15 , 16 ]. In addition, the supplementation of VD 3 affects the plasma chemerin level (RARRES2, retinoic acid 109 receptor responder protein 2) in a rat model of PE [ 17 ], and adiponectin (ADIPOQ) levels in diabetic [ 18 ] as well as PCOS [ 19 ] patients. However, the possible effects of VD 3 on uterine adipokines level in PCOS have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D3 on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats

Pich

Rajewska

Kamińska

et al. 2023

Cells

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Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder with disrupted uterus structure and function. A positive effect of vitamin D3 (VD3) in female reproduction was observed. Chemerin (RARRES2) and adiponectin (ADIPOQ) are the main adipokines whose levels are altered in PCOS patients. Therefore, the aim of this study was to investigate the impact of VD3 supplementation on RARRES2 and ADIPOQ levels in the uterus of PCOS rats. Methods: We analyzed the plasma levels and uterine transcript and protein expression of RARRES2 and ADIPOQ and their receptors (CCRL2, CMKLR1, GPR1, and ADIPOR1 and ADIPOR2, respectively) in rats with letrozole-induced PCOS. Results: In control animals, VD3 did not change plasma levels of both adipokines, while in PCOS rats supplemented with VD3, they returned to control levels. The expression of RARRES2 and all investigated receptors increased in the uterus of VD3-treated rats; however, the levels of Rarres2 and Gpr1 genes remained unchanged. VD3 supplementation decreased RARRES2, CMKLR1, and GPR1 but increased CCRL2 level to the control value. In the uterus of VD3-treated rats, the transcript and protein levels of ADIPOQ and both receptors ADIPOR1 increased. At the same time, VD3 supplementation induced an increase in Adipoq, Adipor1, and Adipor2 gene expression and restored protein levels to control level values. Conclusions: our findings indicate a new mechanism of VD3 action in the uterine physiology of PCOS rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D3 on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats

Pich

Rajewska

Kamińska

et al. 2023

Cells

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“…In our study we also aimed to investigate the role of chemerin as a factor which could link vitamin D, insulin resistance and dyslipidaemia in overweight and obese children and adolescents. Those dependencies are not widely described, but some experimental studies suggest that protective effects of vitamin D supplementation could be exerted by reduction in chemerin levels ( 13 , 14 , 72 ). The number of clinical studies in that field is scarce.…”

Section: Discussionmentioning

confidence: 99%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

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BackgroundVitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence of vitamin D on chemerin levels.Aim of the studyWe aimed to investigate if there is a link between serum 25-hydroksyvitamin D [25(OH)D], chemerin and metabolic profile in overweight and obese children before and after vitamin D supplementation.Material and methodsThe prospective study included 65 overweight and obese children aged 9.08-17.5 years and 26 peers as a control. None of the patients in the study group had received vitamin D within the last twelve months before the study.ResultsThe study group had lower baseline 25(OH)D (p<0.001) and higher chemerin (p<0.001), triglycerides (TG, p<0.001), triglycerides/high density lipoprotein cholesterol (TG/HDL-C, p<0.001), C-reactive protein (CRP, p<0.05), fasting insulin (p<0.001), Homeostasis Model Assessment - Insulin Resistance (HOMA-IR, p<0.001), alanine aminotransferase (ALT, p<0.001) and uric acid (p<0.001) compared to the control group. Baseline vitamin D was related to fasting insulin (R=-0.29, p=0.021), HOMA-IR (R=-0.30, p=0.016), HDL-C (R=0.29, p=0.020) and uric acid (R=-0.28, p=0.037) in the study group. Baseline chemerin was related to insulin at 30’ (R=0.27, p=0.030), 60’ (R=0.27, p=0.033), 90’ (R=0.26, p=0.037) and 120’ (R=0.26, p=0.040) during the oral glucose tolerance test (OGTT) and ALT (R=0.25, p=0.041) in the study group. Correlation between vitamin D and chemerin (R=-0.39, p=0.046) was found only in the control group. After six months of vitamin D supplementation a decrease in CRP (p<0.01), total cholesterol (p<0.05), ALT (p<0.01), glucose at 150’ OGTT (p<0.05) was observed. Moreover, we noticed a tendency for negative association between 25(OH)D and chemerin levels (p=0.085). Multivariable backward linear regression models were build using baseline vitamin D, baseline chemerin and six months chemerin as the dependent variables.ConclusionsOur study confirmed that vitamin D has positive effect on metabolic profile in overweight and obese children. The relationship between vitamin D and chemerin is not clear, nevertheless we have observed a tendency to decrease chemerin concentrations after improving vitamin D status, even without a significant reduction in body fat mass.

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“…According to several studies, low concentrations of 25(OH)D and 1,25(OH)2D correlate with high systolic and diastolic blood pressure (BP) during pregnancy [58][59][60][61][62][63] and only a few papers have demonstrated opposite results [64]. Because vitamin D is an approved supplement during pregnancy, Nassar, Seham Zakaria, and Noha Mohamed Badae tested the hypothesis of lowering systolic BP by vitamin D supplementation and found that its administration reduced systolic BP, proteinuria [65]. Thus, there is strong evidence for the need to measure vitamin D concentrations among pregnant women with any form of hypertension to prescribe optimal doses of vitamin D, thereby possibly providing a reduction in elevated systolic and diastolic blood pressure, reducing the risk of additional complications for the mother and fetus.…”

Section: Effect Of Vitamin D Concentrations On Hypertensive Disorders...mentioning

confidence: 99%

Review: Influence of Vitamin D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes

Karpova¹,

Dmitrenko²,

Arshinova³

et al. 2022

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Vitamin D plays an essential role in embryogenesis and the course of intra- and postnatal periods and is crucially involved in the functioning of the mother-placenta-fetus system. Low quantity of Vitamin D during pregnancy can lead to the elevated risk for preeclampsia occurence. Despite the numerous studies on the association of Vitamin D deficiency and preeclampsia development, the current research on this theme is contradictory. In this review we summarize and analyze study data on the effects of vitamin D deficiency and supplementation on pregnancy, labor, fetal and neonatal outcomes.

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Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin

Cited by 12 publications

References 44 publications

Effect of Vitamin D3 on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats

Effect of Vitamin D3 on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

Review: Influence of Vitamin D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes

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