Protective effect of vitamin C on biochemical alterations induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats

Ambali, SF; Angani, Mary Talatu; AO, Adole; MU, Kawu

doi:10.4172/2161-0525.1000108

Cited by 8 publications

(2 citation statements)

References 46 publications

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“…Reproductive health is gradually deteriorating cides (Wang et al, 2009;Sf et al, 2011;Abdel-Rahim et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Assessment of reproductive toxicity of Cyfluthrin and Pestban either individually or combined in adult male albino rats

Mostafa,

Alaa El-Din,

Kamel

et al. 2023

EJA

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Many studies on individual pesticide risk assessments are available, but the toxicity of combined usage is still to estimate. So, the current study investigated reproductive toxicity induced by exposure to cyfluthrin (CYF) and pestban (PES) and their mixture in adult male albino rats. Forty adult male albino rats were randomized into four groups. All treatments were given daily by oral gavage for 60 days. Group I (control group): this group included 16 rats, divided into two equal subgroups: subgroup Ia (negative control) and subgroup Ib (a vehicle control), in which each rat received 2 ml of corn oil. Group II: CYF group (15.6 mg/kg). Group III; PES group (7.45 mg/kg). Group IV: CYF + PES. Individual CYF and PES exposure significantly decreased testicular weight, serum testosterone level, and epididymal sperm count when compared to the control group. These biochemical changes were confirmed by histological and ultra-structural disarray and reduced immunoreactions of Melan-A (also known as MART-1, Melanoma Antigen Recognized by T-cells), but mutual exposure to both pesticides resulted in a highly significant difference compared to other treated groups. Co-administration of CYF and PES aggravated testicular toxicity, exhausting the endogenous antioxidant status, and down-regulating the immune expression of Melan-A. So, mixing both components can intensify the damaging effects of each compound on testes.

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“…Reproductive health is gradually deteriorating cides (Wang et al, 2009;Sf et al, 2011;Abdel-Rahim et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Assessment of reproductive toxicity of Cyfluthrin and Pestban either individually or combined in adult male albino rats

Mostafa,

Alaa El-Din,

Kamel

et al. 2023

EJA

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show abstract

“…AA, as part of a dietary supplemental regime, was recently shown to reduce BLLs and reverse serum ALAD activity levels in juvenile mice pre-exposed to Pb with the consequent alleviation of deficits in behavior and redox homeostasis, importantly without eliciting any unwanted side-effects [233]. In juvenile rats co-exposed to lead and chlorpyrifos, an organophosphate insecticide, the administration of AA resulted in a marked reduction in oxidative damage concomitantly with the reversal of neurobehavioral and sensorimotor deficits [279]. An enriched milk formula consisting of AA and other antioxidants reduced BLLs and the Pb burden in organs such as the liver, kidney, bones, and brain in mouse pups exposed to Pb, along with ameliorative effects on blood ALAD, protoporphyrin, and thiobarbituric acid reactive substances (TBARS) levels [280].…”

Section: Animal Models: Developing Brainmentioning

confidence: 99%

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Ahmad

Liu

2020

Antioxidants

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Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

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Lead Organ and Tissue Toxicity: Roles of Mitigating Agents (Part 1)

Adikwu¹,

Deo²,

Geoffrey³

et al. 2013

BJPT

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Lead is one of the metals whose toxicological effect in humans and animals is of clinical concerned as reported by researchers. Quite a number of chemical agents have been reported to ameliorate lead associated toxicological effects especially in animal studies. This literary study reviewed reported toxicological effect of lead on the liver, kidney and brain with emphasis on the roles of mitigating chemical agents. In this review it was observed that his to patho logical changes in lead associated he patotoxicity include hepatomegaly with necrosis, formation of hyper plastic nodules and presence of in tranu clear inclusion bodies within hepatocytes. In the kidney reports revealed various degenerative changes with focal tubular necrosis invaded by inflammatory cells in cortical renal tubules, diminution in the amount of filtration slits, apoptosis in epithelial cells of the glomeruli, increase in lysosomal structures, pinocytic vesicles and large mitochondria in proximal tubule cells. Lead altered mRNA levels of the following apoptotic and neurotrophic factors: caspase 2 and 3 and brain-derived neurotrophic factor in the brain. Histopathological changes occurred in gray matter, anterior cingulate cortex, hippocampus and cerebellum of treated animals. Lead exposure altered biomarkers of liver, kidney and brain function with increased lipid peroxidation and decrease antioxidants function. Lead induced toxicities were observed to be mitigated by vitamin C, vitamin E, calcium, magnesium dimercaptosuccinic acid, calcium disodium ethyl diaminetetra acetic acid and selenium. Extracts of plant origin and chemical substances of animal origin were also reported to mitigate these toxicities. One of the commonly reported mechanisms associated with lead toxicological effect is the generation of Reactive Oxygen Species in organs and tissues this may be supported by the mitigating effect of some antioxidants on lead toxicological effects.

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Protective effect of vitamin C on biochemical alterations induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats

Abstract: Protective effect of vitamin C on biochemical alterations induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats.

Cited by 8 publications

References 46 publications

Assessment of reproductive toxicity of Cyfluthrin and Pestban either individually or combined in adult male albino rats

Assessment of reproductive toxicity of Cyfluthrin and Pestban either individually or combined in adult male albino rats

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Lead Organ and Tissue Toxicity: Roles of Mitigating Agents (Part 1)

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