Protective effect of very low concentrations of heavy metals (cadmium and cisplatin) against cytotoxic doses of these metals on renal tubular cell cultures

Delbancut, A.; Dorfman, Pierre; Cambar, J.

doi:10.1016/s0007-0785(05)81041-5

Cited by 2 publications

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“…This line of research clearly demonstrates the biphasic action of a substance: a small dose can exert a stimulatory effect on the recovery and the development of survival capacity of cells that have been previously disturbed by a high dose of the same substance. It is of interest that this stimulatory effect of low dose stress is dependent on the initial exposure condition: the more severe the initial stress conditions, the smaller the 146,172 Bacterial peptides Stimulate adherence Low doses inhibit adherence Leukocytes 173 Podophyllotoxin Cell toxicity Low doses enhance oxidative metabolism Wheat germ 174e176 Arsenite Cell toxicity HDs protect from toxicity Lymphocytes 177,178 Cadmium Cell toxicity HDs protect from cadmium toxicity Neurons 179,180 Glutamate, cycloheximide Neurotoxicity Extremely low doses and HDs protect from neurotoxicity Basophils 14 Histamine Inflammation HDs inhibit basophil activation Basophils 181 Quercetin Inhibit cell activation Low doses enhance formyl-peptide-induced activation concentration required for stimulating survival and hsps induction.…”

Section: Hormesismentioning

confidence: 99%

High-dilution effects revisited. 2. Pharmacodynamic mechanisms

et al. 2014

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The pharmacodynamics aspects of homeopathic remedies are appraised by laboratory studies on the biological effects at various levels (cellular, molecular and systemic). The major question is how these medicines may work in the body. The possible answers concern the identification of biological targets, the means of drug-receptor interactions, the mechanisms of signal transmission and amplification, and the models of inversion of effects according to the traditional 'simile' rule. These problems are handled by two experimental and theoretical lines, according to the doses or dilutions considered (low-medium versus high dilutions). Homeopathic formulations in low-medium dilutions, containing molecules in the range of ultra-low doses, exploit the extreme sensitivity of biological systems to exogenous and endogenous signals. Their effects are interpreted in the framework of hormesis theories and paradoxical pharmacology. The hypotheses regarding the action mechanisms of highly diluted/dynamized solutions (beyond Avogadro-Loschmidt limit) variously invoke sensitivity to bioelectromagnetic information, participation of water chains in signalling, and regulation of bifurcation points of systemic networks. High-dilution pharmacology is emerging as a pioneering subject in the domain of nanomedicine and is providing greater plausibility to the puzzling claims of homeopathy.

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Section: Hormesismentioning

confidence: 99%

High-dilution effects revisited. 2. Pharmacodynamic mechanisms

et al. 2014

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“…20,21 Homeopathic dilutions of cadmium and cisplatin applied to cultured kidney cells confer protection against these same substances when administered in pharmacological concentrations. 22 Furthermore, neuroprotective effects of ultra-low-dose glutamate in the context of glutamate-induced primary rat spinal, cortical, and cerebellar neuronal toxicity have also been reported. 23 In the field of cancer research, a very limited number of reports addressing homeopathy are found in the scientific literature.…”

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confidence: 99%

Effects of Homeopathic Preparations on Human Prostate Cancer Growth in Cellular and Animal Models

MacLaughlin

Gutsmuths²,

Pretner

et al. 2006

Integr Cancer Ther

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The use of dietary supplements for various ailments enjoys unprecedented popularity. As part of this trend, Sabal serrulata (saw palmetto) constitutes the complementary treatment of choice with regard to prostate health. In homeopathy, Sabal serrulata is commonly prescribed for prostate problems ranging from benign prostatic hyperplasia to prostate cancer. The authors' work assessed the antiproliferative effects of homeopathic preparations of Sabal serrulata, Thuja occidentalis, and Conium maculatum, in vivo, on nude mouse xenografts, and in vitro, on PC-3 and DU-145 human prostate cancer as well as MDA-MB-231 human breast cancer cell lines. Treatment with Sabal serrulata in vitro resulted in a 33% decrease of PC-3 cell proliferation at 72 hours and a 23% reduction of DU-145 cell proliferation at 24 hours (P < < .01). The difference in reduction is likely due to the specific doubling time of each cell line. No effect was observed on MDA-MB-231 human breast cancer cells. Thuja occidentalis and Conium maculatum did not have any effect on human prostate cancer cell proliferation. In vivo, prostate tumor xenograft size was significantly reduced in Sabal serrulata-treated mice compared to untreated controls (P = = .012). No effect was observed on breast tumor growth. Our study clearly demonstrates a biologic response to homeopathic treatment as manifested by cell proliferation and tumor growth. This biologic effect was (i) significantly stronger to Sabal serrulata than to controls and (ii) specific to human prostate cancer. Sabal serrulata should thus be further investigated as a specific homeopathic remedy for prostate pathology.

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Protective effect of very low concentrations of heavy metals (cadmium and cisplatin) against cytotoxic doses of these metals on renal tubular cell cultures

Cited by 2 publications

References 0 publications

High-dilution effects revisited. 2. Pharmacodynamic mechanisms

High-dilution effects revisited. 2. Pharmacodynamic mechanisms

Effects of Homeopathic Preparations on Human Prostate Cancer Growth in Cellular and Animal Models

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