Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury

Hu, Zhongpeng; Du, Ruiping; Xiu, Lei; Bian, Ziyao; Ma, Cui; Sato, Naoto; Hattori, Masao; Zhang, Haochi; Liang, Yanchen; Yu, Shui-Xing; Wang, Xiao

doi:10.1016/j.cyto.2019.154917

Cited by 35 publications

(21 citation statements)

References 46 publications

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“…Our results, confirming what is already reported in scientific literature for the antioxidant activity of the G. lucidum extract [ 39 ] in addition to its anticancer, antimicrobial and anti-inflammatory activities [ 39 , 40 ], provide the first evidence of an increase in cell migration and an accelerated healing process and, at the same time, show the proteins involved and the possible molecular mechanisms in these activities.…”

Section: Discussionsupporting

confidence: 92%

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

et al. 2020

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Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer activities are well known. Moreover, lately, there has been an increasing interest from pharmaceutical companies in antiaging G. lucidum-extract-based formulations. Nevertheless, the pharmacological mechanisms of such adaptogenic and regenerative actions remain unclear. The present investigation aimed to explore its molecular and cellular effects in vitro in epidermal keratinocyte cultures by applying liquid chromatography coupled to ion trap time-of-flight mass spectrometry (LCMS-IT-TOF) for analysis of ethanol extracts using ganoderic acid-A as a reference compound. The G. lucidum extract showed a keratinocyte proliferation induction accompanied by an increase of cyclic kinase protein expressions, such as CDK2 and CDK6. Furthermore, a noteworthy migration rate increase and activation of tissue remodelling factors, such as matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9), were observed. Finally, the extract showed an antioxidant effect, protecting from H2O2-induced cytotoxicity; preventing activation of AKT (protein kinase B), ERK (extracellular signal-regulated kinase), p53 and p21; and reducing the number of apoptotic cells. Our study paves the path for elucidating pharmacological properties of G. lucidum and its potential development as cosmeceutical skin products, providing the first evidence of its capability to accelerate the healing processes enhancing re-epithelialization and to protect cells from free-radical action.

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Section: Discussionsupporting

confidence: 92%

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

et al. 2020

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“…Nonetheless, it was not still yet explained clearly in the mechanisms of triterpenoids inhibited lipopolysaccharide to inflammatory responses and liver damages. Especially, Hu et al 45 identified that the use of ethanol extract and triterpenoids from G. lucidum could inhibit inflammatory response with lipopolysaccharide, as well as ganodermanontriol, which inhibits liver damage with lipopolysaccharide. Concomitantly, the aforementioned inhibiting mechanisms were found in this study.…”

Section: Activities Of Ganoderma Lucidum In Disease Treatmentsmentioning

confidence: 99%

Available Chemical Constituents and Activities of Ganoderma Lucidum (Lingzhi or Red Reishi) Utilizing in Disease Treatment: A mini review

2021

J Res Clin Med

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Medicinal mushrooms are known and used to be nutraceuticals for centuries to enhance health benefits as well as to treat several diseases. Among them, Ganoderma Lucidum (i.e.: G. Lucidum, or red Reishi, or Lingzhi) is appreciated as a medicinal mushroom or significant herbal food for treating diseases, extending life and developing drug. It is detected in different locations, likely contributed confusing concerning its classification. Concomitantly, it has utilized as tea, in alcoholic drinking, and as a complementary medicine to bestow numerous health benefits. Thereby, it is truly important to identify chemical constituents and provide its activities in health benefits regarding these products. Herein, we hope that it is likely a good and right approach for utilizing and encouraging this product, as well as its advantages will be shortly summarized in disease treatments.

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“…Mushroom triterpenes can inhibit α-glucosidase activity [44] and thereby reduce blood sugar concentration in animals [45]. Triterpenoids present in Ganoderma lucidum can reduce LPS/ D-Galactosamine-induced liver damage by reducing tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) expression [46]. These triterpenes can also inhibit TLR4-MyD88 (Toll-like receptor 4-myeloid differentiation primary response 88) activity and therefore decrease NF-κB expression [46,47].…”

Section: Triterpenesmentioning

confidence: 99%

The Effects of Fungal Feed Additives in Animals: A Review

Chuang

Hsieh

Lee

2020

Animals

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As probiotics, fungi enhance animal health and are suitable animal feed additives. In addition to brewing fungi, there are also edible and medicinal fungi. Common fungi utilized in feeding programs include Saccharomyces cerevisiae, Aspergillus oryzae, Pleurotus spp., Antrodia cinnamomea, and Cordyceps militaris. These fungi are rich in glucans, polysaccharides, polyphenols, triterpenes, ergosterol, adenosine, and laccases. These functional components play important roles in antioxidant, anti-inflammatory, anti-obesity, and immune system regulation. As such, fungal feed additives could be of potential use when breeding livestock. In previous studies, fungal feed additives enhanced body weight and egg production in poultry and improved the feed conversion rate. Several mycotoxins can be produced by hazardous fungi but fortunately, the cell walls constituents and enzymes of fungal probiotics can also act to decrease the toxicity of mycotoxins. Overall, fungal feed additives are of value, but their safety and usage must be studied further, including cost-benefit economic analyses.

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Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury

Cited by 35 publications

References 46 publications

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

Available Chemical Constituents and Activities of Ganoderma Lucidum (Lingzhi or Red Reishi) Utilizing in Disease Treatment: A mini review

The Effects of Fungal Feed Additives in Animals: A Review

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