Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats

Gupta, Yogendra Kumar; Briyal, Seema; Chaudhary, Geeta

doi:10.1016/s0091-3057(01)00663-3

Cited by 158 publications

(117 citation statements)

References 25 publications

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“…The comparative assessment between Group I and Control showed that Curcumin administration decreased oxidative stress by lowering the serum ABTS value. The values obtained validated the antioxidant effect of the tested substance (Curcumin) and are in agreement with previously published results (Gupta et al, 2009;Sharma et al, 2010;Sahin-Kavakli et al, 2011;Savcum et al, 2013;Hussein et al, 2014;Hismiogullari et al, 2014).…”

Section: Discussionsupporting

confidence: 90%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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Curcumin, a natural phenolic compound is an anti-tumor agent with anti-inflammatory and anti-oxidant properties. The aim of this research was to evaluate oxidative stress levels, the antioxidant activity and Curcumin concentrations by high performance liquid chromatography (HPLC) in an acute experimental inflammation induced by Turpentine oil (intramuscular 0.6 mg kg -1 body weight) and to compare a prophylactic versus a therapeutic regimen of Curcumin (oral suspension of 150 mg Curcumin kg -1 rat weight). Sixteen adult male Wistar rats were assigned to four groups: Control, Group I (Curcumin only), Group II (Curcumin administration, then induced inflammation after 1 hour) and Group III (induced inflammation then Curcumin administration after 2 hours). Oxidative stress was assessed by measuring serum malondialdehide and carbonylated proteins, while systemic and local total antioxidant capacity was determined by ABTS. Local tissue changes (muscle, kidney, liver) were analysed using histopathology. Results showed that acute inflammation significantly increased lipid peroxidation in Groups II and III compared to Control and Group I. A significantly reduced total antioxidant capacity (ATBS) was present in serum and kidney in Group II, also in muscle and kidney in Group III. ABTS levels were significantly increased only in the liver tissue of the animals in Groups II and III with induced inflammation as compared to Group I. This study proved the potential of Curcumin in reducing oxidative stress in both prophylactic and therapeutic regimens.

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Section: Discussionsupporting

confidence: 90%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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“…Curcumin protects neurons from Ab-induced oxidative injury (Huang et al, 2012) and preserves nigrostriatal dopaminergic neurons in a 6-hydroxydopamine hemiparkinsonian model (Tripanichkul & Jaroensuppaperch, 2012). Curcumin administration can prevent hippocampal neuronal death and reduce seizures in mice with systemic administration of kainate (Shin et al, 2007) and attenuates oxidative stress (Gupta et al, 2009). This study was undertaken to investigate whether curcumin could attenuate intrahippocampal kainate-induced seizures, hippocampal neurodegeneration and mossy fiber sprouting (MFS).…”

Section: Introductionmentioning

confidence: 99%

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy

Kiasalari

Roghani

Khalili

et al. 2013

Pharmaceutical Biology

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Context: Temporal lobe epilepsy (TLE) is an intractable neurological disorder. Curcumin is the bioactive component of turmeric with anti-epileptic and neuroprotective potential. Objective: The beneficial effect of curcumin on the intrahippocampal kainate-induced model of TLE was investigated. Materials and methods: Rats were divided into sham, curcumin-pretreated sham, kainate and curcumin-pretreated kainate groups. The rat model of TLE was induced by unilateral intrahippocampal injection of 4 mg of kainate. Rats received curcumin p.o. at a dose of 100 mg/kg/d starting 1 week before the surgery. Seizure activity (SE) and oxidative stressrelated markers were measured. Furthermore, the Timm index for evaluation of mossy fiber sprouting (MFS) and number of Nissl-stained neurons were quantified. Results: All rats in the kainate group had SE, while 28.5% of rats showed seizures in the curcumin-pretreated kainate group. Malondialdehyde and nitrite and nitrate levels significantly increased in the kainate group (p50.01 and p50.05, respectively), and curcumin significantly lowered these parameters (p50.05). Superoxide dismutase activity significantly decreased in the kainate group (p50.05) and curcumin did not improve it. Rats in the kainate group showed a significant reduction of neurons in Cornu Ammonis 1 (CA1) (p50.05), CA3 (p50.005) and hilar (p50.01) regions, and curcumin significantly prevented these changes (p50.05-0.005). The Timm index significantly increased in the kainate group (p50.005), and curcumin significantly lowered this index (p50.01). Discussion and conclusion: Curcumin pretreatment can attenuate seizures, lower some oxidative stress markers, and prevent hippocampal neuronal loss and MFS in the kainate-induced model of TLE.

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“…20 Other studies also showed that in vivo curcumin could inhibit the increase of malondialdehide formation which is a side product of lipid peroxidation, it could also improve glutathion decrease in oxidative stress-induced rat models with kainat acid. 21 Curcumin could also normalize spatial memory of dementia rat models induced with intracerebroventricular streptozotocin. 9,10 However, there are other studies who found oxidant activity of curcumin in certain dosage which could contradict its antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Tumeric Rhizome (Curcuma Longa L) on Radial Arm Maze and Passive Avoidance Test in Trimetiline-Induced Rat Models

Yuliani

Setiani

2017

JKKI

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Backround:Oxidative stress can cause death of hippocampal cells associated to the deficit of learning and memory function. Turmeric rhizome contains curcuminoid which has antioxidant activity that can prevent oxidative stress, thus it was expected to prevent the deficit of learning and memory function on trimethyltin (TMT)-induced rat models. Objectve: This study aimed to determine the effect of turmeric rhizome extract on cognitive learning and memory fuction which was tested using radial arm maze and passive avoidance tests on Wistar rats injected with TMT. Methods: A total of 30 Wistar rats, male, 8-12 weeks of age were divided into 6 groups. The first (normal) group was given CMC-Na, the second (TMT) group was given CMC-Na, the third-the fifth groups were given turmeric rhizome extract (TRE) orally in the dosage of 120mg/kgBW (TRE120), 240 mg/kgBW (TRE240) and 480 mg/kgBW (TRE480), respectivelly. The sixth (P500) group was given piracetam in the dosage of 500 mg/kgBW. Treatments were given for 8 days orally. At day-9th, excluding the first group, all rats were injected with 12 mg/kgBW TMT solution intraperitoneally. One day after TMT injection, the cognitive learning and memory function was measured using radial maze and passive avoidance tests. The datas of cognitve function tests were analyzed statistically by ANOVA test followed by LSD test at significance level 0.05. Results:The results of radial maze and passive avoidance tests showed that the TRE240 group was not statistically significant different with TMT group(p>0.05). However there were significant difference between TRE120 and TMT groups, as well as between TRE480 and TMT groups (p<0.05). The administration of 480 mg/kgBW of TRE showed that its cognitive function was not significantly different with the administration of Piracetam (p>0.05). Conclusion: It can be concluded that the administration of 480 mg/kgBW of TRE can improve cognitive learning and memory function of Wistar rats injected by TMT. Latar Belakang: Stres oksidatif dapat menyebabkanterjadinya kematian sel hippocampus yang dapat berakibat terhadap penurunan fungsi kognitif belajar dan mengingat. Rimpang kunyit (Curcuma longa L) mengandung kurkuminoid yang memiliki aktifitas antioksidan sehingga dapat mencegah stres oksidatif dan diharapkan dapat mencegah penurunan kemampuan belajar dan mengingat pada tikus yang diinduksi zat neurotoksik trimetiltin (TMT).

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Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats

Cited by 158 publications

References 25 publications

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy

The Effect of Tumeric Rhizome (Curcuma Longa L) on Radial Arm Maze and Passive Avoidance Test in Trimetiline-Induced Rat Models

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