Protective effect of tocopheryl esters on pulmonary edema induced by epinephrine infusion in mice

Fujimoto, Masatoshi; Ohgo, Toshiharu; Igarashi, Toshiji; Ohtake, Shinzaburo

doi:10.1254/fpj.72.15

Cited by 1 publication

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“…The vasodilating property of exogenous NAD is well known (19,20), and there is some evidence suggesting that myocardial dysfunctions result from decreased NAD-biosynthesis (21 ,22). Although the specific nature of EN among the tocopheryl esters is not yet completely clarified , there are several pieces of evidence suggesting a higher therapeutic activity of EN compared with other tocopheryl esters, e .g., on skin microcirculation on patients (5), capillary fragility in diabetes (23) and in the aftereffect of cerebral apoplexy (24) , pulmonary edema induced by norepinephrine-infusion in mice (25), alloxan diabetes in rats (26) and platelet aggregation (27). Regarding the result of the present studies that the administration of EN markedly reduced the incidence of fibrotic change in the myocardium, the finding by YASUE et al that the administration of EN accelerated the formation of collateral vessels in experimentally-induced myocardial infarction in dogs (28) should be referred to.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive action of d,l-alpha-tocopheryl nicotinate in rats.

Igarashi

Nakajima

Kobayashi

et al. 1979

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of d,l-alpha-tocopheryl nicotinate (EN) on model hypertension in rats were studied in comparison with d,l-alpha -tocopheryl acetate (EA). The progress of hypertension in young SHR during the 9th to 15th weeks after birth was markedly accelerated by replacing their drinking water with 1% saline. The highly-developed hypertension in old SHR (9months of age) was further advanced by salt loading. Oral administration of 20 or 100mg/kg of EN or 88mg/kg of EA, once a day, delayed the progress of hypertension in young SHR and reduced advanced hypertension in old SHR. An antihypertensive effect of tocopheryl esters was also found in DOCA-salt hypertensive rats. The treatment with EN or EA definitely reduced the incidence of pathological changes accompanying model hypertension such as suppressed weight gain, pulmonary edema, myocardial fibrosis, cerebral hemorrhage and protected the animals from death. In antihypertensive effect. EN was about 5times more active than EA in molecular base, and the effects of EN protecting from pathological changes associated with model hypertension were more definite than those of EA. The treatment with EN or EA reduced water and sodium retention in the DOCA-salt hypertensive animals. This fact may suggest the implication of a mechanism through electrolyte metabolism in the antihypertensive action of these tocopheryl esters.

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Section: Discussionmentioning

confidence: 99%