Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus

Persike, Daniele Suzete; Cunha, Rodrigo L. O. R.; Juliano, Luiz; Silva, Iara Ribeiro; Rosim, Fernanda Elisa; Vignoli, Thiago; Doná, Flávia; Cavalheiro, Ésper A.; Fernandes, Maria José da Silva

doi:10.1016/j.nbd.2008.04.001

Cited by 37 publications

(27 citation statements)

References 40 publications

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“…(B) The rats were pre-treated systemically with RF-07 15 min prior to pilocarpine. As shown, rats did not develop seizures, which exhibited electrographic activity in the hippocampus and cortex similar to the pre-pilocarpine pattern (Persike et al, 2008). Fig.…”

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lsupporting

confidence: 55%

“…The RF-07 was also tested in hippocampal homogenates from rats euthanized 90 min after pilocarpine-induced SE. RF-07 was the most potent inhibitor of caspase-like activity compared with commercial caspase inhibitors (Persike et al, 2008). Based on the results of this study, RF-07 inhibits not only caspases but other proteases that were activated during seizures, such as cathepsins, matrix metalloproteinases and plasminogen activators (see Figure 4).…”

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 79%

“…Inhibition of caspase-3 and -9 provides neuroprotection after SE was induced by kainate (Henshall et al, 2001), and the inhibition of caspase-8 may attenuate neuronal death by decreasing cleaved Bid, caspase-9, and the release of cytochrome c from mitochondria (Li et al, 2006). The caspase inhibition was also used as a neuroprotective strategy against injury caused by SE induced by pilocarpine (Persike et al, 2008). Several studies determined that tellurium compounds, as the non-toxic AS-101, ammonium trichloro(dioxoethylene-O,O′) tellurate, exert anti-apoptotic, anti-inflammatory, and immunomodulatory effects (Okun et al, 2007a;Sredni et al, 2007).…”

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 99%

“…AS-101 is currently being tested in Phase II clinical trials in cancer patients (Sredni et al, 1995, Frei et al, 2008 and was recently suggested as a promising agent for treatment of Parkinson's disease (Sredni et al, 2007). A compound of tellurium(IV), the organotelluroxetane RF-07 (see Figure 2), is an analogue of AS-101 (Persike et al, 2008). The administration of RF-07 prior to pilocarpine significantly blocked the behavioral and electrographic symptoms of SE in rats (Figure 3).…”

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 99%

“…To evaluate if this activity could be related to caspase inhibition, RF-07 was used in an "in vitro" assay to test recombinant caspases -3 and -8. RF-07 showed a potent inhibitory effect on both caspase -3 and -8 (Persike et al, 2008). The RF-07 was also tested in hippocampal homogenates from rats euthanized 90 min after pilocarpine-induced SE.…”

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 99%

See 4 more Smart Citations

Temporal Lobe Epilepsy: Cell Death and Molecular Targets

Fernandes¹,

Cavalheiro²,

Leite³

et al. 2011

Underlying Mechanisms of Epilepsy

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Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lsupporting

confidence: 55%

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 79%

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 99%

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 99%

Section: Caspase Inhibition As Neuroprotective Strategy In Temporal Lmentioning

confidence: 99%

See 3 more Smart Citations

Temporal Lobe Epilepsy: Cell Death and Molecular Targets

Fernandes¹,

Cavalheiro²,

Leite³

et al. 2011

Underlying Mechanisms of Epilepsy

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Organoselenium and organotellurium compounds: Toxicology and pharmacology

Nogueira

Rocha

2011

Patai's Chemistry of Functional Groups

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In the last three decades, the interest in the field of synthesis and reactivity of organoselenium and organotellurium compounds has increased; particularly, in view of the observations that they can exhibit important biological activities. The data presented in this chapter clearly indicate the potential pharmacological and therapeutic uses of organoselenium and organotellurium compounds. Indeed, these classes of molecules exhibit a variety of interesting biological effects, namely antioxidant properties, which can account for their in vitro and in vivo beneficial effects in a wide range of models of different human pathologies. We can conclude that the future of “medicinal chemistry“ of organoselenium and organotellurium compounds will depend on the rational development of new molecules, which can be guided by chemical and biological approaches. Moreover, the structure‐activity relationship for a given class of organoselenium or organotellurium compounds should be used as a toll for screening molecules with high probability of exhibiting low toxicity and high pharmacological activity in mammals.

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Biological and Biochemical Aspects of Tellurium Derivatives

Detty

2011

Patai's Chemistry of Functional Groups

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Biological and biochemical studies of inorganic and organic complexes of tellurium are reviewed. Subject areas include the biosequestration and bioincorporation of tellurite and other inorganic tellurium compounds as well as tellurite‐resistant bacteria. The incorporation of tellurium into amino acids (tellurocysteine) and the formation of unnatural glutathione peroxidases and thioredoxin reductases incorporating tellurocysteine are also described. Low molecular weight organotellurium compounds that mimic glutathione peroxidase and the thioredoxin reductases are discussed as are inorganic and organic tellurium compounds that inhibit cysteine proteases and related enzymes. The interactions of P‐glycoprotein with organotellurium compounds to give stimulators and inhibitors of ATPase activity in the enzyme are described. The role of tellurium‐containing chromophores in the photodynamic therapy of cancer and the photodynamic inactivation of viral and bacterial pathogens is also reviewed. The binding modes of tellurium‐containing chromophores to DNA are also described.

show abstract

Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus

Cited by 37 publications

References 40 publications

Temporal Lobe Epilepsy: Cell Death and Molecular Targets

Temporal Lobe Epilepsy: Cell Death and Molecular Targets

Organoselenium and organotellurium compounds: Toxicology and pharmacology

Biological and Biochemical Aspects of Tellurium Derivatives

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