Protective effect of the apo <i>ɛ</i>2 allele in major depressive disorder in Taiwanese

Fan, Pao‐Luo; Chen, C. D.; Kao, Wei-Tsung; Shu, Bih‐Ching; Lung, For‐Wey

doi:10.1111/j.1600-0447.2005.00686.x

Cited by 23 publications

(17 citation statements)

References 59 publications

(72 reference statements)

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“…One study [66] indicated that the Apo 2 allele was likely to have a protective effect against major depressive disorder in Chinese, and other studies suggest PLA2 is associated with the treatment of bipolar disorder [72,73] . Thus, Apo E and PLA2 may have an association with depressive and bipolar disorders that warrant exploration.…”

Section: Discussionmentioning

confidence: 99%

A Module Map Showing Interaction between Apolipoprotein E and Phospholipase A2 Polymorphism in Lipid Profiles

Lung

Kao²,

Shu³

et al. 2006

Hum Hered

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Objective: Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles. Methods: Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies. Results: By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the ApoΕ2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the ApoΕ2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and ApoΕ2 allele co-existed. Conclusion: The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.

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Section: Discussionmentioning

confidence: 99%

A Module Map Showing Interaction between Apolipoprotein E and Phospholipase A2 Polymorphism in Lipid Profiles

Lung

Kao²,

Shu³

et al. 2006

Hum Hered

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“…Other studies, however, observe no relationship among depression and ApoE ε4 [13,14]. Conversely, there may be a protective affect of the ApoE ε2 allele in major depression: the ApoE ε2 allelic frequency in major depressive disorder (MDD) has been observed to be significantly lower than that among healthy controls [15]; among patients with severe depression, the presence of an ApoE ε2 allele appeared to predict a positive response to electro-convulsive therapy [16,17]. …”

Section: Introductionmentioning

confidence: 99%

ApoE alleles, depression and positive affect in multiple sclerosis

et al. 2009

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“…25 In the present study, the frequency of ApoE-"2 in depressive subjects is only 7.5% (10 + 12/72 + 75), significantly lower than that in the non-depressive subjects (25.2%, 30 + 32/74 + 67). The reasons are probably that ApoE-"2 might reduce the incidence of depression and protect the Chinese population from depression, 26 and also may decrease the vulnerability to depressive symptoms. As it is well-known, lipid metabolism could be affected by the frequency of ApoE.…”

Section: Discussionmentioning

confidence: 99%

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Zhang

Shen

et al. 2015

Renal Failure

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Objective: To explore the relation between the frequencies of apolipoprotein E (ApoE) alleles and the occurrence of depression in patients undergoing hemodialysis in a Chinese population. Methods: We examined the ApoE alleles in a sample of 288 subjects: 72 patients with depression under hemodialysis, 74 patients without depression under hemodialysis, 75 patients with depression under nondialytic treatment and 67 patients without depression under nondialytic treatment. The depression state was assessed using the Center for Epidemiological Studies Depression (CES-D) scale. Associations between the occurrence of depression and the frequencies of ApoE alleles were examined using multinomial logistic regression models with adjustment of relevant covariates. Information about sociodemographics, clinical data, vascular risk factors and cognitive function was also collected and evaluated. Results: The frequencies of ApoE-"2 were significantly different between depressed and non-depressed patients irrespective of dialysis (p50.05), but no significant difference was found in the frequencies of ApoE-"4 (p40.05). Serum ApoE levels were significantly different between depressed and nondepressed patients in the whole sample (p50.05). Multinomial logistic regression models showed significant association between the frequency of ApoE-"2 and the occurrence of depression in the Chinese population after control of relevant covariates, including age, sex, educational level, history of smoking and drinking, vascular risk factors and cognitive function. Conclusions: No association between the frequency of ApoE-"4 and the occurrence of depression was found in patients undergoing hemodialysis. Further research is needed to find out if ApoE-"2 acts as a protective factor in Chinese dialysis population since it might decrease the prevalence of depression and delay the onset age.

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Protective effect of the apo ɛ2 allele in major depressive disorder in Taiwanese

Abstract: The apo epsilon4 allele was not associated with MDD in this study. However, the finding of a lower frequency of the apo epsilon2 allele in MDD could lead to the conclusion that the apo epsilon2 allele likely provides a protective effect against MDD in the Taiwanese population.

Cited by 23 publications

References 59 publications

A Module Map Showing Interaction between Apolipoprotein E and Phospholipase A2 Polymorphism in Lipid Profiles

A Module Map Showing Interaction between Apolipoprotein E and Phospholipase A2 Polymorphism in Lipid Profiles

ApoE alleles, depression and positive affect in multiple sclerosis

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

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