Protective Effect of Tea Saponins on Alcohol-Induced Gastric Mucosal Injury in Mice

Shi, Zhenyu; Long, Xue; Li, Yan; Jin, Jing; Li, Jianfang; Jin, Risheng

doi:10.1021/acsomega.2c05880

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…CD68 is a transmembrane glycoprotein highly expressed by tissue macrophages [28]. The current study CD68 positive immunoreaction was higher in the Ethanol group compared to the other groups, while immunoreaction decreased in the treatment group.…”

Section: Biochemical Findingssupporting

confidence: 43%

The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

Karakoç,

Oruç,

Çeken–Toptancı

et al. 2024

RC FCV-LUZ

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The Pomegranate (Punica granatum) is a commonly found fruit in the Mediterranean and Iran, which has a variety of uses including medicinal purposes, cosmetics, and as a spice in culinary applications. Pharmacological functions of Pomegranate include antioxidation, anti–tumor, anti–hepatotoxicity, anti–lipoperoxidation and antibacterial properties. The aim of this study was to evaluate the therapeutic efficacy of Pomegranate extract by utilizing its antioxidant activity in an experimental rat model of gastritis induced by ethanol. In the study, 24 female Wistar albino rats (180–200 g) were used. Gastritis in rats was induced using Ethanol. In experimental groups, Tumor necrosis factor–alpha, Myloperoxidase, Superoxide Dismutase and Malondialdehyde were examined for biochemical analyzes. Streptavidin peroxidase immunohistochemistry method was applied to gastric tissues with gastritis. A statistically significant difference was observed between Superoxide Dismutase and Meloperoxidase levels. CD8 and CD68 immunoreactivity was higher in the Ethanol group compared to the other groups. A decrease was observed in CD8 and CD68 positive immunoreactivity in Ethanol+Pomegranate extract group compared to Ethanol group. The study found that the immunoreactivity of MHC–I and MHC–II was found in specific locations, namely intraepithelial lymphocytes located in the epithelium, some capillary vessel endothelium, and connective tissue. Changes in anti–oxidative stress markers such as Superoxide Dismutase and Myloperoxidase contributed to the mucosal protective effect of Pomegranate extract in Ethanol–induced gastritis.

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Section: Biochemical Findingssupporting

confidence: 43%

The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

Karakoç,

Oruç,

Çeken–Toptancı

et al. 2024

RC FCV-LUZ

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“…Ethanol expedites gastric damage by promoting the infiltration of immune cells, thus initiating inflammatory cascades [ 29 ]. Neutrophil infiltration into the gastric mucosa plays a pivotal role in the pathogenesis and damage caused by gastric mucosal inflammation and damage [ 30 ]. Migrating neutrophils and macrophages release numerous pro-inflammatory cytokines and ROS during gastric inflammation [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Gastric Mucosal Protective Effects of Cinnamomum cassia in a Rat Model of Ethanol-Induced Gastric Injury

Han,

Song,

Lee

et al. 2023

Nutrients

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Cinnamomum cassia (cassia) is a tropical aromatic evergreen tree of the Lauraceae family well known for its fragrance and spicy flavor and widely used in Asian traditional medicine. It has recently garnered attention for its diverse potential health benefits, including anti-inflammatory, anti-cancer, and anti-diabetic properties. However, the gastroprotective effect of C. cassia, particularly against ethanol-induced gastric damage, remains unclear. We investigated the potential gastroprotective property of C. cassia and the underlying mechanisms of action in a rat model of ethanol-induced gastric injury. To assess its effectiveness, rats were fed C. cassia for a 14-day period prior to inducing gastric damage by oral administration of ethanol. Our results indicated that pre-treatment with C. cassia mitigated ethanol-induced gastric mucosal lesions and bleeding. Reduced gastric acid secretion and expression of acid secretion-linked receptors were also observed. Additionally, pretreatment with C. cassia led to decreased levels of inflammatory factors, including TNF-α, p-p65, and IκBα. Notably, C. cassia upregulated the expressions of HO1 and HSP90, with particular emphasis on the enhanced expression of PAS and MUC, the crucial gastric mucosa defense molecules. These findings suggest that C. cassia has protective effects on the gastric mucosa and can effectively reduce oxidative stress and inflammation.

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“…In addition to the above-described herbal monomer compounds that are useful in the treatment of alcoholic gastric injury, there are other types of.Such as the Tea Saponins [16], thymol [17], geraniol [18], Andrographolide [19] etc，can also play a role in the treatment of alcoholic gastric injury through antiinflammatory and antioxidant effects.…”

Section: Other Chinese Medicinesmentioning

confidence: 99%

Research progress of traditional Chinese medicine and its monomer compounds and extracts on alcoholic gastric injury

Luo

2024

BIO Web Conf.

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Alcoholic gastric injury is a gastric disease caused by excessive intake of alcohol directly stimulating the gastric mucosa or alcohol entering the gastric wall after the dissolution of lipids. Traditional Chinese medicine has a long history in the treatment of alcoholic gastric injury, and has the characteristics of high cure rate, low recurrence rate and small adverse reactions. This article reviews the experimental research and clinical application of traditional Chinese medicine, single compounds of Chinese herbs, traditional Chinese medicine extracts and traditional Chinese medicine compounds in preventing and treating alcoholic gastric injury. This article reviews the effectiveness of herbal medicines for the treatment of alcoholic gastric injury, and their mechanisms of action is presented to provide a reference for further research on anti-alcoholic gastric injury herbal medicines.

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Protective Effect of Tea Saponins on Alcohol-Induced Gastric Mucosal Injury in Mice

Cited by 8 publications

References 34 publications

The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

The protective effect of Pomegranate extract against the experimental gastric ulcer induced by ethanol in rats

Gastric Mucosal Protective Effects of Cinnamomum cassia in a Rat Model of Ethanol-Induced Gastric Injury

Research progress of traditional Chinese medicine and its monomer compounds and extracts on alcoholic gastric injury

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