Protective effect of stem bark ofCeiba pentandralinn. against paracetamol-induced hepatotoxicity in rats

Abstract

The present study reports protective activity of ethyl acetate fraction of methanol extract of stem bark of Ceiba pentandra against paracetamol-induced liver damage in rats. The ethyl acetate fraction (400 mg/kg) was administered orally to the rats with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (100 mg/kg) was used as positive control. High performance thin layer chromatography (HPTLC) fingerprinting of ethyl acetate fraction revealed presence of its major chemical constituents. A significant (P < 0.05) reduction in serum enzymes GOT (ALT), aspartate aminotransferase (AST), GPT alkaline phosphatase (ALP), total bilirubin content and histopathological screening in the rats treated gave indication that ethyl acetate fraction of methanolic extract of Ceiba pentandra possesses hepatoprotective potential against paracetamol-induced hepatotoxicity in rats.

Antidiabetic activity of alkaloids ofAerva lanataroots on streptozotocin-nicotinamide induced type-II diabetes in rats

“…The shade-dried roots were coarsely powdered and subjected to extraction with petroleum ether in a Soxhlet apparatus for removal of fats. The defatted marc was subsequently subjected to methanol extraction (Bairwa et al, 2010;Sethiya et al, 2012). This methanol extract was utilized for the further investigation.…”

Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn.

“…About 160 phytoconstituents from 101 plants have been reported to possess hepatoprotective activity [4] . In India, about 40 polyherbal commercial formulations are available and prescribed by physicians to treat hepatic disorders [5] .…”

Nanofiber devices for the targeted-delivery of therapeutically active plant and herbal ingredients

“…Today, herbal medicines in their novel formulations such as nanoparticles, microemulsions, matrix systems, solid dispersions, liposomes, and solid lipid nanoparticles (SLNs), nanomicellar system, nanotubes, and colloidal nanogels have been developed to be used either alone or in combination with other chemotherapeutic agents (4,6,7). The current focus of pharmaceutical researchers is towards design, characterization and development of targeted-drug delivery systems for synthetic drugs, herbal remedies, and as well as to deliver required quantity of a medicament to targeted diseased area (8)(9)(10)(11)(12)(13)(14).…”