Protective effect of statistically designed and optimized Icariin nanoemulsion on doxorubicin-induced cardiotoxicity: Inhibition of oxidative stress, inflammation, and apoptosis

Md, Shadab; Mahrous, Hatoon Abdul Rahman; Alhakamy, Nabil A.; Shaik, Rasheed A.; Eid, Basma G.

doi:10.1016/j.jddst.2023.104297

Journal of Drug Delivery Science and Technology

2023

DOI: 10.1016/j.jddst.2023.104297

|View full text |Cite

Protective effect of statistically designed and optimized Icariin nanoemulsion on doxorubicin-induced cardiotoxicity: Inhibition of oxidative stress, inflammation, and apoptosis

Shadab Md

Hatoon Abdul Rahman Mahrous

Nabil A. Alhakamy

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Hwang,

Park,

Kang

et al. 2024

Macromol. Rapid Commun.

View full text Add to dashboard Cite

In this study, oil‐in‐water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion‐treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox‐induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes.

show abstract

Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Hwang,

Park,

Kang

et al. 2024

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Protective effect of statistically designed and optimized Icariin nanoemulsion on doxorubicin-induced cardiotoxicity: Inhibition of oxidative stress, inflammation, and apoptosis

Cited by 1 publication

References 40 publications

Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

Contact Info

Product

Resources

About