Protective Effect of Star Anise Seeds on Cadmium Induced Changes on Biochemical Parameters of Rat

Ghozy, Shimaa F.A.E

doi:10.21608/mbse.2017.139078

Cited by 1 publication

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“…(Commonly named star anise), belongs to the genus Illicium of the Illiciaceae family, is an evergreen tree having red-purple flowers and anise-scented star-shaped fruit which is native to the southwest of China and Vietnam [ 19 , 20 ]. It has been widely used spice throughout the world and in traditional medicines for the treatment of stomach aches, carminative, dyspepsia, insomnia, sleeplessness, skin inflammation, antirheumatic, and diuretic [ 21 , 22 , 23 , 24 , 25 ]. It was also tested to have antifungal, antibacterial, antiseptic, chemopreventive, anti-flu, anticoagulant, insecticidal and anti-HIV (human immunodeficiency virus) activities [ 24 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…It was also tested to have antifungal, antibacterial, antiseptic, chemopreventive, anti-flu, anticoagulant, insecticidal and anti-HIV (human immunodeficiency virus) activities [ 24 , 26 ]. Phytochemical analysis showed that star anise is a rich source of polyphenols, and terpenoids like trans-anethole that possess various biological activities including antithrombotic, antihypertensive, antihyperlipidemic and anti-obesity activities [ 23 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced Obesity Rat Model

et al. 2022

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Star anise (Illicium verum Hook. fil.) is commonly utilized as a culinary and medicinal fruit and is most famous in indigenous systems of medicine. The present research work aims to appraise and validate the potential of polyphenol-rich star anise tea (SAT) on oxidative stress, obesity and related biochemical parameters in high-fat-sugar-diet (HFSD)-induced obesity model in rats. SAT was prepared using the traditional method in warm water. The Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis was performed for the simultaneous determination of phenolic acids and flavonoids in SAT. Two doses (250 and 500 mg/kg body weight) were selected to investigate the anti-obesity potential of SAT using HFSD-induced obese rat model. Major (>5 mg/100 mL) phenolic acids in SAT were p-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid while catechin and rutin were the major flavonoids detected in the SAT. SAT exhibited 51.3% DPPH radical scavenging activity. In vivo study showed that higher doses of SAT (500 mg/kg body weight) significantly reduced the body weight increase (74.82%) and BMI (0.64 g/cm2). Moreover, significant reductions in the levels of serum total cholesterol, triglyceride, LDL and VLDL were recorded in all the treatment groups in comparison to the HFSDC group. Furthermore, SAT reduced the alterations in MDA, SOD and GSH levels of experimental groups thus showing the potential against oxidative stress. The SAT-500 group showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison to the HFSDC group. The present study proved that SAT exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.

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