Protective effect of standardized extract of <i>Myrtus communis</i> L. (myrtle) on experimentally bleomycin-induced pulmonary fibrosis: biochemical and histopathological study

Fekri, Mitra Samareh; Mandegary, Ali; Sharififar, Fariba; Poursalehi, Hamid Reza; Nematollahi, Mohammad Hadi; Izadi, Atefe; Mehdipour, Mohammad; Asadi, Afshin; Fekri, Masoomeh Samareh

doi:10.1080/01480545.2018.1459670

Cited by 36 publications

(18 citation statements)

References 28 publications

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“…Fekri et al [ 89 ] evaluated the biochemical and histopathological effect of preventive and therapeutic doses of extracts of myrtle leaves against bleomycin-induced pulmonary fibrosis in an animal model. Inflammatory and oxidative processes are involved in the pulmonary fibrosis.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammatory and oxidative processes are involved in the pulmonary fibrosis. For this reason, the authors [ 89 ] evaluated the effect of myrtle extract on the lipid peroxidation as well as on the activity of catalase in the animal submitted to bleomycin. The oxidation of lipids decreased and the activity of catalase increased, that is, the oxidative stress promoted by bleomycin was reversed with the myrtle treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyproline is an indicator of collagen deposition in lungs in pulmonary fibrosis. The authors also reported the improvement in inflammation and fibrosis in myrtle group [ 89 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

2018

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Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids. In coloured berries, anthocyanins are also present. In M. nivellei extracts are reported for some compounds not described in M. communis so far: 2-hydroxy-1,8-cineole-β-d-glucopyranoside, 2-hydroxy-1,8-cineole 2-O-α-l-arabinofuranosyl (1→6)-β-d-glucopyranoside, rugosin A, and rugosin B. Berries and leaves extracts of both species had antioxidant activity. Comparative studies of the antioxidant activity between leaf and berry myrtle extracts revealed that leaf extracts are best antioxidants, which can be assigned to the galloyl derivatives, flavonols, and flavonols derivatives, although the ratio of these groups of compounds might also have an important role in the antioxidant activity. The anthocyanins present in myrtle berries seem to possess weak antioxidant activity. The antioxidant activity of sample extracts depended on various factors: harvesting time, storage, extraction solvent, extraction type, and plant part used, among other factors. Leaf extracts of myrtle revealed to possess anti-inflammatory activity in several models used. This property has been attributed either to the flavonoids and/or hydrolysable tannins, nevertheless nonprenylated acylphloroglucinols (e.g., myrtucommulone and semimyrtucommulone) have also revealed a remarkable role in that activity. The biological activities of myrtle extracts found so far may direct its use towards for stabilizing complex lipid systems, as prebiotic in food formulations, and as novel therapeutic for the management of inflammation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

2018

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“…Cancer is one of the most challenging disorders around the world (22)(23)(24)(25) and it appears that lung has a particular sensitivity to potentially toxic agents and damage, resulting in various lung disorders (26)(27)(28)(29). Gene therapy is considered a promising strategy in promoting the health of a number of inherited and acquired human conditions such as: cancer, diabetes, cardiovascular diseases and mental disorders (30).…”

Section: Discussionmentioning

confidence: 99%

ZEB1 and ZEB2 gene editing mediated by CRISPR/Cas9 in A549 cell line

Mohammadinejad¹,

Sassan²,

Pardakhty³

et al. 2020

BLL

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OBJECTIVES: One of the best approaches for recognition of protein function is the induction of mutations for a gene knockout. In line with this strategy, gene editing tools allow researchers to induce these mutations. Lung cancer is one of the leading causes of death worldwide. ZEB1 and ZEB2 genes are the candidates for this disease. METHODS: The ZEB1 and ZEB2 knockout in the non-small cell lung cancer cell line (A549 cell) was investigated. Purifi cation of recombination plasmids was performed from bacteria and then was transported to the A549 cell line. The deletion of ZEB1 and ZEB2 were examined by PCR. RESULTS: The results demonstrated the mutation and deletion in ZEB1 and ZEB2 genes. Based on the fi ndings of this study, A549 cells were transfected with the vectors carrying the sgRNA/Cas9, simultaneously. The DNA fragment demonstrated the presence of indels in target sites as well as provided the potential of CRISPR/Cas9 system. CONCLUSION: CRISPR/Cas9 offers a great potential as an effi cient technique for editing of ZEB1 and ZEB2 genes in A549 cell line (Tab. 1, Fig. 6, Ref.

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“…and digestive system disorders (Aykac et al, 2019;Hennia, Miguel, & Nemmiche, 2018;Jabri, Marzouki, & Sebai, 2018). Antioxidants or the anti-inflammatory properties of M. communis leaves have been reported in previous experimental studies, such as liver fibrosis (Sen et al, 2016), ear edema and granuloma (Maxia, Frau, Falconieri, Karchuli, & Kasture, 2011), mouse paw edema (Rossi et al, 2009), pulmonary fibrosis (Samareh-Fekri et al, 2018), and colonic inflammation in rats (Sen et al, 2017). Nevertheless, the effect of M. communis subsp.…”

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confidence: 98%

Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

et al. 2019

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In this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty‐two rats were grouped as the saline‐pretreated control (C), MC‐pretreated control (MC), saline‐pretreated AP (AP), and MC‐pretreated AP (MC + AP) groups. To induce AP, cerulein was administered (50 µg/kg) two times. The rats were given MC for 14 days before cerulein injection. Six hours after the final cerulein injection, the rats were sacrificed. Pancreatic damage was associated with an increase in the serum activity of lipase and amylase, the pancreatic activity of myeloperoxidase, and the pancreatic level of malondialdehyde, interleukin‐1β, and interleukin‐6. AP also led to a decrease in the pancreatic level of anti‐inflammatory interleukin‐10 and glutathione. Pretreatment with MC before the induction of AP significantly reduced the pancreatic damage observed during the histological examination as well as reversed the biochemical changes evoked by AP. Practical applications Acute pancreatitis is characterized by high mortality (average about 5%; severe cases may reach about 30%). The current treatment for acute pancreatitis is mainly symptomatic. The introduction of herbal drugs may lead to the development of a new strategy in the treatment of this disease. This study revealed that MC reduced pancreatic injury by decreasing pro‐inflammatory cytokines, increasing antioxidant capacity and anti‐inflammatory cytokine, IL‐10. To the authors’ knowledge, this research is the first report showing that MC inhibits the development of AP. This observation suggests that MC may be useful in the prevention and the treatment of AP in clinical settings.

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Protective effect of standardized extract of Myrtus communis L. (myrtle) on experimentally bleomycin-induced pulmonary fibrosis: biochemical and histopathological study

Cited by 36 publications

References 28 publications

Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

ZEB1 and ZEB2 gene editing mediated by CRISPR/Cas9 in A549 cell line

Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

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