Protective effect of Spirulina platensis against physiological, ultrastructural and cell proliferation damage induced by furan in kidney and liver of rat

Khalil, Samah R.; Salem, Hoda Foad; Metwally, Mohamed M.M.; Emad, Rasha M.; Elbohi, Khlood M.; Ali, Sozan A.

doi:10.1016/j.ecoenv.2020.110256

Cited by 28 publications

(13 citation statements)

References 60 publications

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“…Our results are in agreement with an earlier report, which indicated that CPC administration restored the Bax/Bcl2 equilibrium and also attenuated the release of caspase-3 and caspase-9 [63]. Several evidences imply that the herbal source of CPC, S. platensis, is known to exert anti-apoptotic and anti-inflammatory activities [20][21][22]. Figure 6 represents the comprehensive sketch of the molecular mechanisms involved in the ameliorative effect of CPC against Aβ-provoked AD.…”

Section: Discussionsupporting

confidence: 92%

“…C-phycocyanin (CPC) is a phycobiliprotein pigment and also a vital phytocomponent of Spirulina platensis, an edible blue-green alga. It also exhibits anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, nephroprotective, and wound healing effects [18][19][20][21][22]. Singh et al [23] reported that phycocyanin might offer neuroprotection in AD by inhibiting the activity of β-secretase.…”

Section: Introductionmentioning

confidence: 99%

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Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease

Gan

Yan

et al. 2020

Translational Neuroscience

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AbstractBackground:Amyloid-beta (Aβ) plaque deposits and neurofibrillary tangles containing tau proteins are the key pathognomonic manifestations of Alzheimer’s disease (AD). Lack of holistic drugs for AD has reinvigorated enthusiasm in the natural product-based therapies. In this study, our idea to decipher the beneficial effects of C-phycocyanin (CPC) in the management of AD is buoyed by its multifaceted and holistic therapeutic effects.Methods:We evaluated the effect of CPC treatment on epigenetic factors and inflammatory mediators in a mouse with oligomeric Aβ1-42-induced AD. Besides, the cognitive function was evaluated by the spatial memory performance on a radial arm maze.Results:The results showed cognitive deficit in the mice with AD along with upregulated HDAC3 expression and diminished miRNA-335 and brain-derived neurotrophic factor (BDNF) expressions. In addition, inflammation was provoked (manifested by increased interleukins (IL)-6 and IL-1β) and neuronal apoptosis was accelerated (indicated by increased Bax, caspase-3, and caspase-9 along with decreased Bcl2) in the hippocampus of the mice with AD. Interestingly, CPC treatment in the mice with AD improved spatial memory performance and decreased the perturbations in the epigenetic and inflammatory biofactors.Conclusion:These results underscore that mitigation of inflammation via regulation of epigenetic factors might be the key pathway underlying the ameliorative effect of CPC against the aberrations in AD. Our findings provide the rationale for considering CPC as a viable therapeutic option in the management of AD.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease

Gan

Yan

et al. 2020

Translational Neuroscience

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“…The main concern regarding polyphenols is related to their high potential application for food preservation and for therapeutic beneficial use [14]. Besides, the use of natural antioxidant products from plant sources has shown promising evidence in ameliorating the toxicity of diverse xenobiotics in in vivo models [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

et al. 2020

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This study aimed to describe the protective efficacy of Moringa oleifera ethanolic extract (MOEE) against the impact of cobalt chloride (CoCl2) exposure on the rat’s kidney. Fifty male rats were assigned to five equal groups: a control group, a MOEE-administered group (400 mg/kg body weight (bw), daily via gastric tube), a CoCl2-intoxicated group (300 mg/L, daily in drinking water), a protective group, and a therapeutic co-administered group that received MOEE prior to or following and concurrently with CoCl2, respectively. The antioxidant status indices (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), oxidative stress markers (hydrogen peroxide (H2O2), 8-hydroxy-2-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)), and inflammatory response markers (nitric oxide (NO), tumor necrosis factor (TNF-α), myeloperoxidase (MPO), and C-reactive protein (CRP)) were evaluated. The expression profiles of pro-inflammatory cytokines (nuclear factor-kappa B (NF-kB) and interleukin-6 (IL-6)) were also measured by real-time quantitative polymerase chain reaction (qRT-PCR). The results showed that CoCl2 exposure was associated with significant elevations of oxidative stress and inflammatory indices with reductions in the endogenous tissue antioxidants’ concentrations. Moreover, CoCl2 enhanced the activity of the NF-κB inflammatory-signaling pathway that plays a role in the associated inflammation of the kidney. MOEE ameliorated CoCl2-induced renal oxidative damage and inflammatory injury with the suppression of the mRNA expression pattern of pro-inflammatory cytokine-encoding genes. MOEE is more effective when it is administered with CoCl2 exposure as a prophylactic regimen. In conclusion, MOEE administration exhibited protective effects in counteracting CoCl2-induced renal injury in rats.

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“…The stained sections were examined microscopically and any histopathological alterations observed were recorded. This was followed by multiparametric quantitative lesion scoring for the hepatic parenchyma in all groups following the protocol described by Khalil et al 38 with a few modifications. For each animal, five randomly selected, non-duplicated microscopic profiles (40 × objective) were captured using an AmScope digital camera attached to an Olympus light microscope.…”

Section: Histological Examinations After Decapitation Typical Tissumentioning

confidence: 99%

Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

Soliman

Aldhahrani

Metwally

2021

Sci Rep

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The herb thyme (Thymus vulgaris) has multiple therapeutic uses. In this study, we explored how T. vulgaris leaf extract protects liver cells against sodium nitrite-(NaNO2) induced oxidative stress. Mice were divided into four groups; each group received one of the following treatments orally: saline; T. vulgaris extract alone; NaNO2 alone; or T. vulgaris extract + NaNO2. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), IL-1β, IL-6, TNF-α, and total proteins were measured in serum using standard methods. TNF-α, hemooxygenase-1 (HO-1), thioredoxin, SOD, and GSH synthase, all of which are linked to oxidative stress, were measured using quantitative real-time PCR (qRT-PCR). In mice treated with T. vulgaris extract, the effect of NaNO2 on ALT and AST levels and total proteins was reduced, and its effect on antioxidant levels was reversed. Normally, NaNO2 causes hepatocyte congestion and severe hepatic central vein congestion. Tissues in the mice treated with T. vulgaris were restored to normal conditions. Our results demonstrate that NaNO2-induced hepatic injury is significantly reduced by pretreatment with T. vulgaris extract, which protects against hepatic oxidative stress and its associated genes at the biochemical, molecular, and cellular levels.

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Protective effect of Spirulina platensis against physiological, ultrastructural and cell proliferation damage induced by furan in kidney and liver of rat

Cited by 28 publications

References 60 publications

Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease

Effect of C-phycocyanin on HDAC3 and miRNA-335 in Alzheimer’s disease

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

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