Protective Effect of Spin-Labeled 1-Ethyl-1-nitrosourea against Oxidative Stress in Liver Induced by Antitumor Drugs and Radiation

Gadjeva, V.; Grigorov, Boncho G.; Nikolova, Galina; Toleкova, A.; Zheleva, A.; Vasileva, M.

doi:10.1155/2013/924870

Cited by 5 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combinations of SLENU and natural antioxidants reduce oxidative toxicity as compared to the same combinations of SLCNUgly. Our study confirms once again in vivo protective abilities of SLENU against oxidative toxicity of clinically used antitumor antibiotics and radiation 38,39 . Gadjeva and co-workers, 1994 40 using in vitro spintrapping EPR method demonstrated that SLENU possessed high superoxide radical scavenging activity (SSA) even higher than antioxidant Trolox.…”

Section: Discussionsupporting

confidence: 83%

Comparative Real Time EPR Investigation of Natural and Synthetic Antioxidants: As Potential Anticancer Agents and Radio-protectors

et al. 2017

View full text Add to dashboard Cite

The purpose of this study was to evaluate and compare the free-radical scavenging activity against DPPH stable radical and protective properties of the natural products SQGD and P. corylifolia and synthetic nitroxyl-free radical containing nitrosoureas SLENU and SLCNUgly against in vivo oxidative toxicity of antitumor drug CCNU. It was found statistically significant increase in the DPPH radical-scavenging capacity of both extracts with increase of radiation. The natural antioxidants were localised mainly in the organs and blood after EPR biodistribution study. All combinations of natural extracts/ synthetics agents exhibited considerably lower levels of Asc. radicals as compared to controls. It should be mentioned that the natural antioxidants possess higher oxidative protection in comparison with the synthetic antioxidants. Considerable decrease in ROS production in livers of mice was found after treatment with SQGD, P. corylifolia and SLENU, alone, compared to controls.In conclusion, because of well-expressed antioxidant activities of natural and synthetic antioxidants they might be used in the combination anticancer chemotherapy for reducing toxicity caused by anticancer drugs and/or low levels radiation therapy.

show abstract

Section: Discussionsupporting

confidence: 83%

Comparative Real Time EPR Investigation of Natural and Synthetic Antioxidants: As Potential Anticancer Agents and Radio-protectors

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Using the EPR method we had shown that spin-labelled nitrosoureas could scavenge 2 O − ⋅ and thus exhibited high superoxide scavenging activity (SSA) [15]. Moreover, by our studies, we have demonstrated beneficial effects of SLENU, recently synthesized in our laboratory, on drug-induced oxidative toxicity in rat blood and in liver of mice [16]- [18].…”

Section: Introductionmentioning

confidence: 97%

Spin-Labelled 1-Ethyl-1-Nitrosourea Prevents Doxorubicin and Bleomycin-Induced Oxidative Stress in Lungs, Hearts and Kidneys of Tumour-Bearing Mice

Gadjeva¹,

Nikolova²,

Grigorov³

et al. 2014

ABC

View full text Add to dashboard Cite

This study was carried out to determine the possible protective effect of 1-ethyl-3-[4-(2, 2, 6, 6-tetramethylpiperidine-1-oxyl)]-1-nitrosourea (SLENU), recently synthesised in our laboratory on doxorubicin and bleomycin-induced oxidative toxicity in C57 black tumour-bearing mice. Specifically, alterations in some biomarkers of oxidative stress, such as lipid peroxidation products measured as malondialdehyde (MDA) levels and activities of the antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT), were studied in lung, heart and kidney homogenates isolated from C57 black tumor-bearing mice after i.p. treatment with solutions of DOX (60 mg/kg) and BLM (60 mg/kg). The same biomarkers were also measured after i.p. pretreatment of mice with SLENU (100 mg/kg). After treatment with doxorubicin, heart and kidney homogenates of mice had significantly higher productions of lipid peroxidation compared to lung homogenates. It was accompanied by increased activity of the antioxidant defence enzyme superoxide dismutase and decreased activity of catalase. Bleomycin-induced oxidative stress was confirmed by significantly higher production of lipid peroxidation in lungs compared to heart homogenates, elevation of the antioxidant activity of superoxide dismutase and decreased activity of catalase enzymes. After pretreatment of the mice with SLENU, the levels of all studied oxidative stress biomarkers were significantly improved

show abstract

“…In vitro was detected the synergistic effect of the spin-labeled nitrosourea 1-ethyl-3-[4-(2,2,6,6tetramethylpiperidine-1-oxyl)] -1-nitrosourea (SLENU) on the cytotoxicity of bleomycin and farmorubicin in human lymphoid leukemic tumor cells [21]. Recent studies have demonstrated the protective effect of SLENU against drug-induced oxidative stress in liver and blood in experimental animals [22,23].…”

mentioning

confidence: 99%

Options for reducing oxidative toxicity of L-dopa by combination with synthetic or natural radical protectors

Nikolova¹

2018

TJS

Self Cite

View full text Add to dashboard Cite

Parkinson disease (PD) is a multifactorial disease that is not well-established. It takes a leading place among contemporary frequent diseases of the central nervous system (CNS). The levodopa (L-dopa) clinical effect is diminished by motor complications resulting from prolonged treatment. Due to the L-dopa neurotoxic effect in the disease treatment, the L-dopa administration is delayed as long as possible in order to avoid side effects. In addition, combining L-dopa therapy with antioxidants (from natural or synthetic origin), may decrease side-effects and provide symptomatic relief. The aim of the current research is through experimental model of healthy mice to explore the possibility to reduce the oxidative stress (OS) induced by the L-dopa drug after its combining with: an essential oil isolated from Rosa damascena Mill., the vitamin C and synthetic antioxidant 1-ethyl-3- [4- (2,2,6,6-tetramethylpiperidine-1-oxyl)] - 1-nitrosourea SLENU. The antioxidants protective effects against the L-dopa oxidative toxicity were evaluated through the oxidative stress indicators - the lipid and protein oxidation end products – measured as MDA, protein carbonyl content, and advanced glycation end products (AGEs) in blood plasma of experimental mice.

show abstract

Protective Effect of Spin-Labeled 1-Ethyl-1-nitrosourea against Oxidative Stress in Liver Induced by Antitumor Drugs and Radiation

Cited by 5 publications

References 34 publications

Comparative Real Time EPR Investigation of Natural and Synthetic Antioxidants: As Potential Anticancer Agents and Radio-protectors

Comparative Real Time EPR Investigation of Natural and Synthetic Antioxidants: As Potential Anticancer Agents and Radio-protectors

Spin-Labelled 1-Ethyl-1-Nitrosourea Prevents Doxorubicin and Bleomycin-Induced Oxidative Stress in Lungs, Hearts and Kidneys of Tumour-Bearing Mice

Options for reducing oxidative toxicity of L-dopa by combination with synthetic or natural radical protectors

Contact Info

Product

Resources

About