Protective effect of soluble fiber from <i>Undaria pinnatifida</i> on vascular endothelium in hypercholesterolemic rabbits

Xiao, Hong-Bo; Fang, Jun; Lu, Xiangyang; Liu, Zhikui; Chen, Xiaojun; Liu, Jinhui; Su, Jianming; Yi, Jine; Sun, Zhi-Liang

doi:10.4141/cjas08132

Cited by 3 publications

(2 citation statements)

References 32 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the mechanism responsible for the protective effect of fiber on endothelial dysfunction is not well described. Dietary soluble fiber may stimulate NO generation and reduce ET-1 level (Xiao et al, 2009). In this study, it is possible that the protective effects of agar fiber on the vascular endothelium may be related to an improvement in NO production and/or a reduction in ET-1 concentration.…”

Section: Resultsmentioning

confidence: 99%

Beneficial Effects of Low-Calorie-Carbohydrate/High-Agar Diet on Cardiometabolic Disorders Associated with Non-Alcoholic Fatty Liver Disease in Obese Rats

Louala

Lamri‐Senhadji

2019

pnf

View full text Add to dashboard Cite

Energy restriction and low carbohydrate diets are recommended as nutrition therapies to prevent becoming overweight or obese. However, their beneficial effects in non-alcoholic fatty liver disease (NAFLD) are less well investigated. In addition, the effects of the type of polysaccharides incorporated into these diets and their contents have been scarcely studied. Therefore, this study aimed to elucidate whether low-calorie-carbohydrate high-agar diets could improve liver metabolic dysfunction, membrane fluidity, oxidative damage, and endothelial dysfunction in obese rats. Obesity was induced by feeding rats a high-fat diet (HFD) for 10 weeks. The obese rats were then divided into two homogenous groups: the first group was fed low-calorie-carbohydrate/high-agar diet (LCC/HA) and the second continued to consume the HFD for 4 weeks [obese control (Ob-C)]. Normo-ponderal rats were fed a normal diet during the entire study, and were used as the control (N-C). Compared with the Ob-C group, body weight, hepatic lipids, low density lipoproteins cholesterol (C), the non esterified cholesterol/phospholipids ratio, serum transaminases activities, and lipid peroxidation markers (thiobarbituric acid reactive substances and lipid hydroperoxides) were reduced in LCC/HA group (P<0.05). However, the serum concentration of high density lipoproteins-C was enhanced (P<0.05). In addition, we observed improved antioxidant defence and endothelial dysfunction associated with antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, and catalase (P<0.05), and nitric oxide level (P<0.05). These findings suggest that hypocaloric diets low in energy and carbohydrates and rich in agar may be beneficial against HFD-induced hepatic steatosis damage, and may be a promising therapeutic strategy to counteract NAFLD development associated with obesity.

show abstract

Section: Resultsmentioning

confidence: 99%

Beneficial Effects of Low-Calorie-Carbohydrate/High-Agar Diet on Cardiometabolic Disorders Associated with Non-Alcoholic Fatty Liver Disease in Obese Rats

Louala

Lamri‐Senhadji

2019

pnf

View full text Add to dashboard Cite

show abstract

“…As mentioned earlier, abnormal production of NO and elevation of ADMA levels induce endothelial dysfunction. Our recent studies reported that the protective effects of UP soluble fiber on endothelium‐mediated vasorelaxation may be related to an improved NO production in hypercholesterolemic rabbits (Xiao et al . 2009).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Soluble Fiber From Undaria Pinnatifida on Vascular Endothelium in Mice

Xiao

Sun

et al. 2011

Journal of Food Biochemistry

View full text Add to dashboard Cite

The objective of this study was to investigate the protective effect of soluble fiber extracted from Undaria pinnatifida (UP) on vascular endothelium and the mechanisms involved. The experiments were performed in aorta and plasma from C57BL/6J control and apolipoprotein E deficient (ApoE -/-) mice treated or not with UP soluble fiber (5 or 10%) for 8 weeks. UP soluble fiber treatment improved endothelium-dependent vasorelaxation, increased the maximal relaxation value, and decreased the half-maximum effective concentration concomitantly with a decrease in asymmetric dimethylarginine (ADMA) and malondialdehyde plasma concentrations, and increase in the expression as well as activity of dimethylarginine dimethylaminohydrolase II in ApoE -/mice. Treatment with UP soluble fiber also significantly decreased reactive oxygen species production in mice aorta. The present results suggest that the protective effect of UP soluble fiber on vascular endothelium may be associated with a decrease in ADMA level in mice.

show abstract

Undaria pinnatifida soluble fiber regulates Angptl3-LPL pathway to lessen hyperlipidemia in mice

Xiao

Zhang

et al. 2013

J Physiol Biochem

View full text Add to dashboard Cite

Angiopoietin-like protein 3 (Angptl3)-lipoprotein lipase (LPL) pathway may be a useful pharmacologic target for hyperlipidemia. The present study was conducted to test the effect of soluble fiber extracted from Undaria pinnatifida (UP), on hyperlipidemia in apolipoprotein E-deficient (ApoE(-/-)) mice. Forty mice were divided into four groups (n = 10): control group (C57BL/6J mice), ApoE(-/-) mice group, and two groups of ApoE(-/-) mice treated with UP fiber (5 or 10 % per day). UP soluble fiber treatment significantly decreased plasma and hepatic total cholesterol, triglycerides levels, plasma low-density lipoprotein cholesterol, and malondialdehyde concentrations and increased plasma high-density lipoprotein cholesterol level and downregulated protein expression of Angptl3 concomitantly with upregulated protein expression of LPL. In addition, T0901317 caused elevated expression of hepatic Angptl3 protein, and the effect of T0901317 was also abrogated by UP soluble fiber in C57BL/6J mice. The present results suggest that the UP soluble fiber regulates Angptl3-LPL pathway to lessen hyperlipidemia in mice.

show abstract

Protective effect of soluble fiber from Undaria pinnatifida on vascular endothelium in hypercholesterolemic rabbits

Cited by 3 publications

References 32 publications

Beneficial Effects of Low-Calorie-Carbohydrate/High-Agar Diet on Cardiometabolic Disorders Associated with Non-Alcoholic Fatty Liver Disease in Obese Rats

Beneficial Effects of Low-Calorie-Carbohydrate/High-Agar Diet on Cardiometabolic Disorders Associated with Non-Alcoholic Fatty Liver Disease in Obese Rats

Protective Effects of Soluble Fiber From Undaria Pinnatifida on Vascular Endothelium in Mice

Undaria pinnatifida soluble fiber regulates Angptl3-LPL pathway to lessen hyperlipidemia in mice

Contact Info

Product

Resources

About