Protective effect of sodium propionate in Aβ1-42 -induced neurotoxicity and spinal cord trauma

Filippone, Alessia; Lanza, Marika; Campolo, Michela; Casili, Giovanna; Paterniti, Irene; Cuzzocrea, Salvatore; Esposito, Emanuela

doi:10.1016/j.neuropharm.2020.107977

Cited by 29 publications

(27 citation statements)

References 35 publications

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“…A recent study demonstrated that propionate, similarly to butyrate, may inhibit the activation of NF-κB in colon adenocarcinoma cell line [5] with a consequent reduction of pro-inflammatory factors expression such as TNF-α and IL-1β in colon tissues. Moreover, we have previously shown the neuroprotective effect of SP in an in vitro neuroinflammatory model and in vivo model of spinal cord injury (SCI), recognizing in SP an optimal therapeutic target for neuroinflammatory disorders [12]. In this study, we confirmed the ability of SP to contain the peripheral acute inflammation trough the down- GSH is produced in tissues as a result of GSH peroxidase activity and it is immediately reduced by GSH reductase, thereby maintaining constant levels of reduced glutathione in the normal tissue.…”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory and Antioxidant Effects of Sodium Propionate

Filippone

Lanza

Campolo

et al. 2020

IJMS

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The major end-products of dietary fiber fermentation by gut microbiota are the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate, which have been shown to modulate host metabolism via effects on metabolic pathways at different tissue sites. Several studies showed the inhibitory effects of sodium propionate (SP) on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. We carried out an in vitro model of inflammation on the J774-A1 cell line, by stimulation with lipopolysaccharide (LPS) and H2O2, followed by the pre-treatment with SP at 0.1, 1 mM and 10 mM. To evaluate the effect on acute inflammation and superoxide anion-induced pain, we performed a model of carrageenan (CAR)-induced rat paw inflammation and intraplantar injection of KO2 where rats received SP orally (10, 30, and 100 mg/kg). SP decreased in concentration-dependent-manner the expression of cicloxigenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) following LPS stimulation. SP was able to enhance anti-oxidant enzyme production such as manganese superoxide dismutase (MnSOD) and heme oxygenase-1 (HO-1) following H2O2 stimulation. In in vivo models, SP (30 and 100 mg/kg) reduced paw inflammation and tissue damage after CAR and KO2 injection. Our results demonstrated the anti-inflammatory and anti-oxidant properties of SP; therefore, we propose that SP may be an effective strategy for the treatment of inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory and Antioxidant Effects of Sodium Propionate

Filippone

Lanza

Campolo

et al. 2020

IJMS

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“…Murine RAW 264.7 macrophage cell line was acquired from American Type Culture Collection (ATCC) and cultured as reported by [ 15 ]. The cellular viability of RAW 264.7 was assessed by MTT assay as previously described by [ 16 ]. The extent of reduction of MTT to formazan was quantified by 232 measurement of optical density at 550 nm (OD550) with a microplate reader (Multiskan FC Thermo Scientific, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Properties of a New Food Supplement Containing Actinia equina Extract

et al. 2020

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Marine species represent a great source of biologically active substances; Actinia equina (AE), an Anthozoa Cnidaria belonging to the Actinidiae family, have been proposed as original food and have already been included in several cooking recipes in local Mediterranean shores, and endowed with excellent nutraceutical potential. The aim of this study was to investigate some unexplored features of AE, through analytical screening and an in-vitro and in-vivo model. An in-vitro study, made on RAW 264.7 stimulated with H2O2, showed that the pre-treatment with AE exerted an antioxidant action, reducing lipid peroxidation and up-regulating antioxidant enzymes. On the other hand, the in-vivo study over murine model demonstrated that the administration of AE extracts is able to reduce the carrageenan (CAR)-induced paw edema. Furthermore, the histological damage due to the neutrophil infiltration is prevented, and this highlights precious anti-inflammatory features of the interesting food-stuff. Moreover, it was assessed that AE extract modulated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and The nuclear factor erythroid 2–related factor 2 (Nrf-2) pathways. In conclusion, our data demonstrated that thanks to the antioxidant and anti-inflammatory properties, AE extract could be used as a new food supplement for inflammatory pathology prevention.

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“…Propionate and other SCFAs have been investigated in relation to a number of other auto-immune disease states. Animal and in vitro studies have reported an association of propionate with metabolism, diabetes and hepatic steatosis (53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63), inflammation (35,(64)(65)(66)(67)(68)(69) and colitis inflammation (70). (36).…”

Section: Modification Of the Immune System Through Scfas Can Improve Auto-immune Diseasementioning

confidence: 99%

Review: The Nutritional Management of Multiple Sclerosis With Propionate

Vige

Calder

2021

Front. Immunol.

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Over the last 15 years there has been an accumulation of data supporting the concept of a gut-brain axis whereby dysbiosis of the gut microbiota can impact neurological function. Such dysbiosis has been suggested as a possible environmental exposure triggering multiple sclerosis (MS). Dysbiosis has been consistently shown to result in a reduction in short-chain fatty acid (SCFA) producing bacteria and a reduction in stool and plasma levels of propionate has been shown for MS patients independent of disease stage and in different geographies. A wealth of evidence supports the action of propionate on T-cell activity, resulting in decreased T-helper cell 1 (Th1) and T-helper cell 17 (Th17) numbers/activity and increased regulatory T cell (Treg cell) numbers/activity and an overall anti-inflammatory profile. These different T-cell populations play various roles in the pathophysiology of MS. A recent clinical study in MS patients demonstrated that supplementation of propionate reduces the annual relapse rate and slows disease progression. This review discusses this data and the relevant mechanistic background and discusses whether taming of the overactive immune system in MS is likely to allow easier bacterial and viral infection.

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Protective effect of sodium propionate in Aβ1-42 -induced neurotoxicity and spinal cord trauma

Cited by 29 publications

References 35 publications

The Anti-Inflammatory and Antioxidant Effects of Sodium Propionate

The Anti-Inflammatory and Antioxidant Effects of Sodium Propionate

Properties of a New Food Supplement Containing Actinia equina Extract

Review: The Nutritional Management of Multiple Sclerosis With Propionate

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