Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Doğan, Duygu; Meydan, İsmet; Kömüroğlu, Ahmet Ufuk

doi:10.1155/2022/6541026

Cited by 15 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CP causes oxidative stress by directly damaging mtDNA, which impairs appropriate expression of mitochondrial enzymes forming the respiratory chain, and thus induces oxidative stress" [40]. "The decrease in GSH level and antioxidant enzymes and increase in MDA due to oxidative stress are seen as the main reason for the toxicity caused by CP" [43].…”

Section: Discussionmentioning

confidence: 99%

The Renoprotective Effects of Liraglutide and Alfacalcidol against Cisplatin Induced Nephrotoxicity in Mice

Fehil,

Yassin,

Mahmoud

et al. 2024

JAMMR

View full text Add to dashboard Cite

Cisplatin (CP) is an important platinum-based chemotherapy agent widely used to treat solid tumors. However, nephrotoxicity is the main limiting adverse effect in 25%–35% of patients treated with even a single dose of CP. This study aimed to evaluate the role of liraglutide (LIRA) and alfacalcidol (ALFA), each of them alone and in combination, in prevention of CP-induced nephrotoxicity. Forty male albino mice were divided into five groups including normal control group and groups CP, CP with LIRA, CP with ALFA, or CP with LIRA and ALFA. Nephrotoxicity was induced by single intraperitoneal injection of CP in a dose 12mg/kg. LIRA and/or ALFA treatment was started 5 days before induction of nephrotoxicity and continued till the end of experiment. Kidney function tests, oxidative stress and ferroptosis parameters were assessed. Histopathological and immunohistochemical examination were performed on kidney tissues. Both LIRA and ALFA monotherapy resulted in a significant improvement in kidney function tests, increased antioxidant levels, inhibition of ferroptosis and improved histopathological findings. LIRA showed more improvement compared to ALFA and their combination showed better results than each one alone. In conclusion, LIRA and ALFA either alone or in combination, represent a promising preventive modality for amelioration of CP-induced nephrotoxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

The Renoprotective Effects of Liraglutide and Alfacalcidol against Cisplatin Induced Nephrotoxicity in Mice

Fehil,

Yassin,

Mahmoud

et al. 2024

JAMMR

View full text Add to dashboard Cite

show abstract

“…As mentioned in the Introduction, oxidative stress is reportedly related to the deterioration of cats with CKD. 1,8,13,14 The evaluation of oxidative markers could have a deeper significance if there is an association between mortality and the levels of oxidative markers in cats, just as in humans. 7 In this study, 8-OHdG and MDA were identified as markers of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…There are several reports of oxidative stress contributing to the development and exacerbation of renal interstitial injury in rodent models with chronic kidney disease (CKD). 1 – 3 Oxidative stress in the kidney is also an important factor in the progression of CKD in cats. 4 Several biomarkers have been reported to reflect oxidative injury and pathogenesis of CKD in cats, for example liver-type fatty acid-binding protein (L-FABP), F2-isoprostane and transforming growth factor beta 1 (TGF-β1).…”

Section: Introductionmentioning

confidence: 99%

8-Hydroxy-2′-deoxyguanosine and malondialdehyde in plasma and their association with disease severity in 20 cats with chronic kidney disease

Nishi

Harada

Hori

et al. 2023

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives Oxidative stress is associated with the development and progression of chronic kidney disease (CKD) in humans. The aim of this study was to evaluate the concentrations of oxidative stress markers, 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in the plasma and urine of cats with different stages of CKD. Methods Plasma and urine samples were collected from cats with CKD that were referred to the Veterinary Medical Center of the University of Tokyo between April 2019 and October 2022. Plasma and urine samples were collected from healthy cats (n = 6 at most), cats with stage 2 CKD (n = 8) and stage 3–4 CKD (n = 12), and cats with idiopathic cystitis (disease control, n = 5). Plasma and urine concentrations of 8-OHdG and MDA were measured using ELISA and thiobarbituric acid reactive substances assay kits, respectively. Results The median plasma 8-OHdG concentrations were 0.156 ng/ml (<0.125–0.210 ng/ml) in the healthy group, <0.125 ng/ml (range <0.125 ng/ml) in the idiopathic cystitis group, 0.246 ng/ml (range 0.170–0.403 ng/ml) in cats with stage 2 CKD and 0.433 ng/ml (range 0.209–1.052 ng/ml) in cats with stage 3–4 CKD. Concentrations in stage 3–4 CKD were significantly higher than those in the healthy and disease control groups. Plasma MDA concentrations were low in the healthy and disease control groups and significantly higher in cats with stage 3–4 CKD. In every cat with CKD, plasma 8-OHdG and MDA concentrations were positively correlated with plasma creatinine concentrations (8-OHdG, rs = 0.68; MDA, rs = 0.67). Urinary 8-OHdG/urinary creatinine (u-CRE) and urinary MDA/u-CRE levels did not differ significantly between the groups; however, it was difficult to evaluate them because of the small sample size. Conclusions and relevance This report shows that plasma 8-OHdG and MDA concentrations increase with the severity of feline CKD. These markers may be useful for assessing oxidative stress in cats with CKD.

show abstract

“…GA and its ester derivatives are widely used for an edible purposes, as flavoring agents, and as preservatives in the food industry [ 34 ]. Besides their edible use, there are diverse scientific reports on their biological and pharmacological activities, such as antioxidant, antibacterial, antiviral, anti-inflammatory, anticancer, and protective effects against cardiovascular, neuropsychological, gastrointestinal, and metabolic diseases [ 35 , 36 , 37 ]. The antitumor activity of GA is reported in various female cancers, such as its potentiating chemotherapeutic effect of paclitaxel in cervical cancer [ 38 ], while it is observed to potentiate paclitaxel and carboplatin effect in breast cancer [ 39 ].…”

Section: Phenolic Acids Involved In the Regulation Of Molecular Targetsmentioning

confidence: 99%

Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives

et al. 2023

View full text Add to dashboard Cite

Cancer is a global health concern with a dynamic rise in occurrence and one of the leading causes of mortality worldwide. Among different types of cancer, ovarian cancer (OC) is the seventh most diagnosed malignant tumor, while among the gynecological malignancies, it ranks third after cervical and uterine cancer and sadly bears the highest mortality and worst prognosis. First-line treatments have included a variety of cytotoxic and synthetic chemotherapeutic medicines, but they have not been particularly effective in extending OC patients’ lives and are associated with side effects, recurrence risk, and drug resistance. Hence, a shift from synthetic to phytochemical-based agents is gaining popularity, and researchers are looking into alternative, cost-effective, and safer chemotherapeutic strategies. Lately, studies on the effectiveness of phenolic acids in ovarian cancer have sparked the scientific community’s interest because of their high bioavailability, safety profile, lesser side effects, and cost-effectiveness. Yet this is a road less explored and critically analyzed and lacks the credibility of the novel findings. Phenolic acids are a significant class of phytochemicals usually considered in the nonflavonoid category. The current review focused on the anticancer potential of phenolic acids with a special emphasis on chemoprevention and treatment of OC. We tried to summarize results from experimental, epidemiological, and clinical studies unraveling the benefits of various phenolic acids (hydroxybenzoic acid and hydroxycinnamic acid) in chemoprevention and as anticancer agents of clinical significance.

show abstract

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Cited by 15 publications

References 30 publications

The Renoprotective Effects of Liraglutide and Alfacalcidol against Cisplatin Induced Nephrotoxicity in Mice

The Renoprotective Effects of Liraglutide and Alfacalcidol against Cisplatin Induced Nephrotoxicity in Mice

8-Hydroxy-2′-deoxyguanosine and malondialdehyde in plasma and their association with disease severity in 20 cats with chronic kidney disease

Phenolic Acids-Mediated Regulation of Molecular Targets in Ovarian Cancer: Current Understanding and Future Perspectives

Contact Info

Product

Resources

About