Protective effect of Silymarin against kidney injury induced by carbon tetrachloride in male rats

Ahmed, M.; Tayawi, Hussien Mohammad; Ibrahim, M.K.

doi:10.33899/ijvs.2019.125529.1051

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…Methotrexate acts as inhibitor of dihydrofolate reductase affecting on the production of folic acid and works to prevent the manufacture of certain amino acids and protein synthesis (18), where it effects on the liver functions and leads to a decrease in the albumin production in addition to injury of glomeruli causing increase albumin filtration in urine represented by present of interstitial nephritis (19). One consequence of the albumin decline is present of a high free binding plasma drug which increases the methotrexate toxicity.…”

Section: Discussionmentioning

confidence: 99%

Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats

Alabdaly¹,

Saeed²,

Al-hashemi³

2021

IJVS

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Section: Discussionmentioning

confidence: 99%

Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats

Alabdaly¹,

Saeed²,

Al-hashemi³

2021

IJVS

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“…AHE treatment significantly ameliorates the damaging effects of DOX on kidney morphology. Previous research approves that silymarin possesses excellent renoprotective effect against drug and chemical-induced renal alterations and regarded as a potentially pragmatic candidate in combined chemotherapy regimens by functioning as a potent quencher of radical species in the kidney thus precluding the toxic influences at both the histological and biochemical levels ( Shahbazi et al, 2012 , Ahmed et al, 2019 , Nouri and Heidarian, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction

Afsar

Razak

Almajwal

et al. 2020

Saudi Journal of Biological Sciences

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Doxorubicin (DOX) is an anthracycline drug used for cancer treatment. However, its treatment is contiguous with toxic effects. We examined the nephroprotective potential of A. hydaspica polyphenol-rich ethyl acetate extract (AHE) against DOX persuaded nephrotoxicity. 36 male Sprague Dawley rats were randomly assorted into 6 groups. Control group received saline; DOX group: 3 mg/kg b.w. dosage of DOX intraperitoneally for 6 weeks (single dose/week). In co-treatment groups, 200 and 400 mg/kg b.w AHE was given orally for 6 weeks in concomitant with DOX (3 mg/kg b.w, i.p. injection per week) respectively. Standard group received silymarin 400 mg/kg b.w daily + DOX (single dose/week). Biochemical kidney function tests, oxidative stress markers, genotoxicity, antioxidant enzyme status, and histopathological changes were examined. DOX caused significant body weight loss and decrease kidney weight. DOX-induced marked deterioration in renal function indicators in both urine and serum, i.e., PH, specific gravity, total protein, albumin, urea, creatinine, uric acid, globulin, blood urea nitrogen, etc. Also, DOX treatment increases renal tissue oxidative stress markers, while lower antioxidant enzymes in tissue along with degenerative alterations in the renal tissue compared to control rats. AHE co-treatment ameliorates DOX-prompted changes in serum and urine chemistry. Likewise, AHE treatment decreases sensitive markers of oxidative stress and prevented DNA damages by enhancing antioxidant enzyme levels. DOX induction in rats also caused DNA fragmentation which was restored by AHE co-treatment. Moreover, the histological observations evidenced that AHE effectively rescued the kidney tissue from DOX interceded oxidative damage. Our results suggest that co-treatment of AHE markedly improve DOX-induced deleterious effects in a dose-dependent manner. The potency of AHE co-treatment at 400 mg/kg dose is similar to silymarin. These outcomes revealed that A. hydaspica AHE extract might serve as a potential adjuvant that avoids DOX-induced nephrotoxicity.

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“…As EtBr is considered as a toxic and dangerous due to its potency as a mutagenic or teratogenic agent, where it increased glycolytic activity, increased oxidative stress, and mitochondrial ultrastructural changes (4). Silymarin, the main flavonoid and active ingredient of Silybum marianum (milk thistle) fruit and seeds, is considered as a natural antioxidant, which has been commonly used as a phytotherapy for several medicinal applications such as liver disorders (5).…”

Section: Introductionmentioning

confidence: 99%

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

Abdulshaheed¹,

Al-Saaidi²,

Al-Arak³

2021

IJVS

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This study was conducted to qualify the ameliorating potency of silymarin against toxicity in ethidium bromide (EtBr) treated female rats. Eighty female Wistar rats aged 100 days, weighted 170-175 g were randomly allocated to control, orally supplemented with drinking water, and three treated groups, orally supplemented with silymarin 200 mg/kg BW, EtBr 10 mg/kg BW, and combination of EtBr and silymarin (SEtBr), respectively. Each group was allocated to two subgroups, sacrificed after 20 and 40 days of treatment. Bodyweight gain, uteri, and ovaries weight were recorded. Ovarian samples were obtained for histopathological examination. EtBr group females recorded the lowest body weight gain, relative weights of ovaries and uteri, and ovarian follicle number, whereas S group females recorded the highest body weight gain and follicular number, while the ovaries and uteri weights were either higher or close to the control group, at both experimental periods. Histopathological findings of both periods revealed necrosis, cirrhosis, ischemia, and prominent hemorrhage in the blood capillaries in EtBr treated ovarian tissues, but many of the ovarian follicles being mature and the atretic follicles were hence found to be high in number, whereas silymarin treated females showed normal ovarian tissues and viable ovarian follicles as that in control females. The combinationtreated females, at 20 days, revealed necrotic primary ovarian follicles with some macrophages infiltration, whereas 40 days' period showed normal ovarian cortex, medulla, and ovarian follicles. In conclusion, silymarin treatment in combination with EtBr has a potent amelioration effect against ovarian toxicity, in a duration-dependent manner.

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Protective effect of Silymarin against kidney injury induced by carbon tetrachloride in male rats

Cited by 7 publications

References 14 publications

Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats

Effect of methotrexate and aspirin interaction and its relationship to oxidative stress in rats

Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction

Ovario-utero protective effect of silymarin in ethidium bromide treated female rats

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