Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury

Jang, Young-Joo; Back, Moon Jung; Fu, Zhicheng; Lee, Juhyun; Won, Jong Hoon; Ha, Hae Chan; Lee, Hae Kyung; Jang, Ji Min; Choi, Jong Min; Kim, Dae Kyong

doi:10.1007/s12272-016-0716-x

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…LPS is an important component of the cell wall of Gram‐negative Bacillus spp. LPS triggers similar pathological processes to those observed in ALI . Neutrophil accumulation results in the production of reactive oxygen species and granular enzymes, leading to lung tissue damage via induction of an inﬂammatory cascade .…”

Section: Discussionmentioning

confidence: 71%

Alkannin attenuates lipopolysaccharide‐induced lung injury in mice via Rho/ROCK/NF‐κB pathway

Lin

Hou

et al. 2019

J Biochem & Molecular Tox

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We investigated the effects and associated mechanism of alkannin (AL) on lipopolysaccharide (LPS)-induced acute lung injury in a mouse model. Pretreatment with AL in vivo significantly reduced the lung wet/dry weight ratio and inhibited lung myeloperoxidase activity and malondialdehyde content, while increasing superoxide dismutase activity. Hematoxylin and eosin staining demonstrated that AL attenuated lung histopathological changes. In addition, AL-inhibited overproduction of proinflammatory cytokines in bronchoalveolar lavage fluid and lung tissues in LPS-injured mice and LPS-exposed A549 cells. Further analysis showed that AL-inhibited induction of the Rho/ROCK/NF-κB pathway via LPS-induced inflammation in mice and A549 cells. Fasudil, a selective ROCK inhibitor, showed similar effects. Overall, the findings indicate that AL suppresses the expression of messenger RNAs and proteins associated with Rho/ROCK/NF-κB signaling to effectively ameliorate lung injury. K E Y W O R D S alkannin, lipopolysaccharide, lung injury, Rho/ROCK/NF-κB

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Section: Discussionmentioning

confidence: 71%

Alkannin attenuates lipopolysaccharide‐induced lung injury in mice via Rho/ROCK/NF‐κB pathway

Lin

Hou

et al. 2019

J Biochem & Molecular Tox

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“…Lung volume reduction, lung ventilation/blood imbalance, and even progressive hypoxia and respiratory distress are observed during ALI. LPS causes similar pathological process of ALI and is widely used to induce ALI [10]. In the present study, we employed LPS-induced ALI model to show that GAA and Dex significantly decreased lung W/D weight ratio, MPO activity, MDA content and the levels of TNF-α, IL-1β and IL-6, while increased SOD activity in LPS-stimulated mice.…”

Section: Discussionmentioning

confidence: 73%

Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice

Wan

Sun

et al. 2019

Bioscience Reports

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The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway.

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“…Values are expressed as means ± SEM. Compared with control: # P < 0.05, ## P < 0.01; compared with OVA:*P < 0.05, **P < 0.01. of various respiratory tracts, which aggravates inflammation [17]. The respiratory syncytial virus (RSV) is the most infectious disease.…”

Section: Discussionmentioning

confidence: 99%

“…For asthma in infants and children, an important high-risk factor for its aggravation is the common virus invasion of various respiratory tracts, which aggravates inflammation [ 17 ]. The respiratory syncytial virus (RSV) is the most infectious disease.…”

Section: Discussionmentioning

confidence: 99%

Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice

Yang

et al. 2021

Inflammation

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The aim of this study is to investigate the effects of ganoderic acid A (GAA) on OVA-induced asthma in mice. Mouse asthma model was established by ovalbumin (OVA) in vitro. Diff-Quik staining was used to observe the total numbers of cells and the number of classification cells in each group, and HE staining was used to observe lung inflammation in lung tissue sections. ELISA was used to detect the effect of GAA on the levels of interleukin-4 (IL-4), IL-5, and IL-13 in serum and lung tissue. The expression levels of TLR/NF-κB were detected by Western blot. Immunohistochemistry was used to observe the expression changes of TLR4 and P-P65. Compared with the normal group, the inflammatory cell count, IL-4, IL-5, and IL-13 expression in the model group increased, and TLR/NF-kB signal protein expression increased. Compared with the model group, in GAA group, the number of inflammatory cells, the expression of IL-4, IL-5, and IL-13 decreased, and the expression of TLR/NF-kB signaling protein decreased. GAA regulated lung inflammation in asthmatic mice by inhibiting TLR/NF-kB signaling pathway.

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Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury

Cited by 13 publications

References 35 publications

Alkannin attenuates lipopolysaccharide‐induced lung injury in mice via Rho/ROCK/NF‐κB pathway

Alkannin attenuates lipopolysaccharide‐induced lung injury in mice via Rho/ROCK/NF‐κB pathway

Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice

Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice

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