Protective effect of sea cucumber (Acaudina molpadioides) fucoidan against ethanol-induced gastric damage

Fucoidan from <i>Cucumaria frondosa</i> Inhibits Pancreatic Islets Apoptosis Through Mitochondrial Signaling Pathway in Insulin Resistant Mice

“…RNA extract and amplification were performed according the methods described in the literatures with modification (Chang et al, 2012;Sikdar S, 2013;Srzentić et al, 2015). Briefly, the total RNA from gastrocnemius or adipose tissue was extracted using TRIzol reagent, and 1 μg RNA was reversely transcribed to cDNA with M-MLV.…”

Proximate composition and nutritional quality of deep sea growth sea cucumbers (Stichopus japonicus) from different origins

“…3 In addition, sea cucumber contains various bioactive substances such as polysaccharides and collagen. 4,5 Numerous studies on the physiological functions of sea cucumber have been published, such as antitumor activity, 6,7 anticoagulant activity, 8 -10 antithrombotic activity, 11,12 antioxidant activity, 13,14 enhancement of immune competence, 15,16 etc.…”

Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4

“…Fucoidan isolated from the sea cucumber (SC-FUC) is a sulfated polysaccharide containing a substantial percentage of L-fucose and sulfate ester groups (17). SC-FUC has been reported to have anticoagulant and antithrombotic properties (18), protection from gastric damage (19) and inhibition for osteoclastogenesis (20). In addition, multiple reports showed that fucoidan isolated from alga exhibited anti-hyperglycemia effects, for example, fucoidan extracted from Saccharina japonica had a pronounced hypoglycemic effect in alloxan-induced diabetic rats (21) and fucoidan derived from the Sporophyll of Undaria pinnatifida could regulate blood glucose homoeostasis in C57BL/KSJmþ/þdb and C57BL/KSJ db/db mice (22), while the literature on SC-FUC is scarce.…”