Protective effect of rutin on spinal motor neuron in rats exposed to acrylamide and the underlying mechanism

Zhang, Tong; Zhang, Chunmei; Luo, Yuyou; Liu, Shuping; Liu, Siyuan; Li, Lixia; Ma, Yuxin; Liu, Jing

doi:10.1016/j.neuro.2023.01.009

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…The current results also revealed a significant reduction in AChE activity in brain tissue due to ACR treatment. Similar findings have been previously observed and were attributed to the production of free radicals and adducting presynaptic protein thiol groups by ACR with subsequent disruption of the antioxidant balance within the brain [63,64] . Also, the concentration of GABA in brain tissues was increased due to current ACR neurotoxicity.…”

Section: The Protective Effect Of Ppe and Alg-ppe Nps Against Acr Ind...supporting

confidence: 89%

Protective effect of Punica granatum peel extract and its alginate-encapsulated nanoparticles against acrylamide-induced neurotoxicity in rats

Tawfek,

El-Houssiny,

Ahmed-Farid

et al. 2023

Egyptian Journal of Pure and Applied Science

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The goal of the present study is to assess the possible protective effect of the pomegranate peel extract (PPE) and its alginate-nanoencapsulated form (Alg-PPE NPs) against rat neurotoxicity induced by acrylamide (ACR). The prepared Alg-PPE NPs were characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, Fourier transmission infrared microscopy (FITR), differential scanning calorimetry (DSC) as well as in vitro cytocompatibility and drug release analysis. The active ingredients of the two examined extracts were identified using HPLC analysis. ACR was intraperitoneally injected (50 mg/kg bw) three times per week for 2 consecutive weeks into male Wistar rats for the induction of neurotoxicity. PPE or Alg-PPE NPS were given in daily doses (200 mg/kg bw) orally for two consecutive weeks either individually or combined with acrylamide injection. Results revealed that ACR injection induced neurotoxicity manifested by the significant increase in tumor necrosis factor alpha, gamma aminobutyric acid, and DNA fragmentation level in brain tissues of treated animals. Meanwhile, the brain levels of brainderived neurotrophic factor, total antioxidant capacity, acetylcholinesterase activity, dopamine, serotonin, norepinephrine, glutamine, glycine, and aspartate were significantly decreased. These changes in tissue biochemical parameters were associated with histopathological alternations in the architecture of brain tissues. Amelioration of the acrylamide-induced brain toxicity was observed following co-administration of either PPE or Alg-PPE NPs with a higher degree of protection observed with the nanoparticles form as a result of increased bioavailability. The protective effect of the studied extracts was ascribed mainly to the antioxidant potential of their phenolic and flavonoids components. In conclusion, Alg-PPE NPs can be regarded as a potential therapeutic agent that offers protection against acrylamide neurotoxicity, however, to fully understand the neuroprotective mechanism of Alg-PPE NPs at the molecular level, additional research must be done to characterize their active principles.

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Section: The Protective Effect Of Ppe and Alg-ppe Nps Against Acr Ind...supporting

confidence: 89%

Protective effect of Punica granatum peel extract and its alginate-encapsulated nanoparticles against acrylamide-induced neurotoxicity in rats

Tawfek,

El-Houssiny,

Ahmed-Farid

et al. 2023

Egyptian Journal of Pure and Applied Science

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“…Catechins enhance skeletal muscle performance, due to epicatechin gallate with the strongest differentiation, significantly reduced the adhesion force, stiffness, and enhanced C2C12 cell differentiation [180]; The antibacterial activity was hydrogen bonding, hydrophobic and electrostatic interaction between epicatechin gallate and anionic carboxymethyl Poria cocos polysaccharide [181]. Rutin with neuronprotection has an anti-oxidative impact through up-regulating the expression of P-ERK and Nrf2 proteins in the ERK/Nrf2 pathway [182]. Rutin and quercetin with antioxidants can reduce the formation of protein oxidation products and the highest clearance rates for DPPH (62.74 %) and ABTS+ (71.14 %) [183].…”

Section: Flavonoids Mechanismmentioning

confidence: 99%

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Zeng,

Ahmed,

et al. 2024

Preprint

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Nutrition therapy is the best solution to human chronic diseases, especially beer and barley which play an important role in human health and civilization. We demonstrated the actional mechanism of functional ingredients in beer and barley to combat chronic diseases, based on PubMed, google, CNKI, and ISI Web of Science databases from 1997 to 2024. Beer is rich in functional ingredients that is a complex of barley malt and hops; the health effect of beer against 26 chronic diseases is highly similar to that of barley, due to molecular mechanism of polyphenols (phenolic acids, flavonoids), melatonin, minerals, bitter acids, vitamins, and peptides. The ancient German Beer Purity Law provides much scientific basis today, especially indirectly supporting the human one cell disease theory. Low purine beer can be produced by enzymatic and biological degradation and adsorption of purines as well as dandelion addition. Functional beer with low purine and high active ingredients made from Beer Purity and barley malt as well as functional foods addition will be the key and important development direction, such as ginger beer and ginseng beer, especially coix-lily beer at the ancestors ca. 9000 years ago. This review paper not only reveals the actional mechanism of beer overcoming human chronic diseases, but also provides scientific basis for the development of functional beer for the prevention and treatment of human chronic diseases.

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Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells

Li,

Zhang,

Zhang

et al. 2024

NeuroToxicology

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Protective effect of rutin on spinal motor neuron in rats exposed to acrylamide and the underlying mechanism

Cited by 5 publications

References 44 publications

Protective effect of Punica granatum peel extract and its alginate-encapsulated nanoparticles against acrylamide-induced neurotoxicity in rats

Protective effect of Punica granatum peel extract and its alginate-encapsulated nanoparticles against acrylamide-induced neurotoxicity in rats

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells

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