Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats

Koda, Tomoko; Kuroda, Yoshiki; Imai, Hideki

doi:10.1016/j.nutres.2008.06.004

Cited by 81 publications

(44 citation statements)

References 38 publications

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“…Previously, we showed that rutin supplementation to the diet protected against TMT-induced spatial memory dysfunction in rats (Koda et al 2008). In this study, we demonstrated that TMT administration induced neuron loss in the CA1, CA3a, CA3b, and CA3c regions.…”

Section: Discussionsupporting

confidence: 56%

“…rutin group) dissolved in water or water alone (both for the control group and the rutin group) was administered orally. The TMT dose was determined from our previous study (Koda et al 2008). To observe the progression of TMT-induced impairment and protective effects of rutin supplementation, the rats were decapitated 5, 10, and 20 days after the TMT administration.…”

Section: Methodsmentioning

confidence: 99%

“…Animal experiments showed that rutin has many beneficial effects, such as anti-inflammatory effect (Cruz et al 1998;Guardia et al 2001;Kim et al 2005;Meydani 2001), neuroprotective effect (Gupta et al 2003), and anti-hyperglycaemic effect (Kamalakkannan and Prince 2006). We previously demonstrated that toxicant-induced spatial memory impairment and hippocampal pyramidal cell damage were corrected in rats when fed with a diet supplemented with rutin (Koda et al 2008). Experimental study has shown that spatial memory in rats is dependent on the hippocampus (Morris et al 1982).…”

Section: Introductionmentioning

confidence: 99%

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Rutin Supplementation in the Diet has Protective Effects Against Toxicant-Induced Hippocampal Injury by Suppression of Microglial Activation and Pro-Inflammatory Cytokines

2009

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Section: Discussionsupporting

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rutin Supplementation in the Diet has Protective Effects Against Toxicant-Induced Hippocampal Injury by Suppression of Microglial Activation and Pro-Inflammatory Cytokines

2009

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“…The distribution of phenolic acids and flavonoids as detected from HPTLC profiles revealed the presence of chlorogenic acid, cinnamic acid, myrecetin, apigenin, rutein and catechin in concentrations of 303.3, 8.5, 53.1, 3.7, 727.8 and 263.8 μg/ ml respectively in C. pepo. Rutein, one of the primary flavonoids present in C. pepo, has been studied for beneficial human health effects, such as antioxidant effect and antiinflammatory effect (Koda et al 2008). Chlorogenic acid (66.5 μg/ml) and ferulic acid (37.3 μg/ml) were detected as phenolic acids in ME of C.maxima whereas; no flavonoid amongst the studied flavonid compounds was detected in C.maxima extract.…”

Section: Identification Of Phenolic Acids and Flavonoids By Hptlcmentioning

confidence: 99%

Antioxidant activity of various extracts of selected gourd vegetables

Yadav

et al. 2016

J Food Sci Technol

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Study was conducted to evaluate the antioxidative activity of methanolic (ME), ethanolic (EE) and butanolic extracts (BE) of selected gourd vegetables. The antioxidant activity was investigated using different assays namely ferric thiocyanate test (FTC), thiobarbituric acid test (TBA), ferric reducing antioxidant power (FRAP) and DPPH free radicals scavenging test. A densitometric HPTLC analysis was performed for the analysis of phenolic acids and flavonoids. Different extracts of the selected gourd vegetables revealed different antioxidant activity. Different extracts of Lagenaria siceraria, Momordica charantia and Luffa cylindrica revealed significantly higher (p < 0.05) concentrations of total phenols, flavonids, tannins and carotenoids content and also the antioxidant activity in comparison to remaining vegetable extracts. Correlation studies indicated that FRAP test best described the antioxidant activity of phenols, flavonoids and carotenoids (r = 0.854, 0.692 and 0.915 respectively). HPTLC profiles revealed the presence of maximum number of phenolic acids and flavonoids in L. siceraria and M. charantia.

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“…Rutin has antidepressant-like effect 16 , anti-inflammatory 17,18 , and protective effect against hepatototoxicity and memory impairment 18 .…”

Section: Bacterial Typementioning

confidence: 99%

Untitled

2012

IJPSR

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The common usage of Galium spp. in the Ethiopian traditional medicine, as described in few documentations, are generally related to diseases associated with the nervous system, the immune system, infections and inflammation. Preliminary phytochemical and antimicrobial screening on extracts of the aerial parts of Galium spurium (subspecies africanum) was done in order to partly rationalize some of the claimed traditional uses of the plant. Results of the preliminary antimicrobial screening on extracts of G. spurium showed only weak antibacterial activity. The preliminary phytochemical screening revealed the presence of flavonoids and phenolics compounds. As phenolics and flavonoids are known to display multiple health benefits, the claimed traditional uses of the plant could be justified more through the possible pharmacological effects of these components than its weak antibacterial activities.

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Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats

Cited by 81 publications

References 38 publications

Rutin Supplementation in the Diet has Protective Effects Against Toxicant-Induced Hippocampal Injury by Suppression of Microglial Activation and Pro-Inflammatory Cytokines

Rutin Supplementation in the Diet has Protective Effects Against Toxicant-Induced Hippocampal Injury by Suppression of Microglial Activation and Pro-Inflammatory Cytokines

Antioxidant activity of various extracts of selected gourd vegetables

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