Protective effect of royal jelly on fluoride-induced nephrotoxicity in rats via the some protein biomarkers signalling pathways: a new approach for kidney damage

Aslan, Abdullah Nabi; Beyaz, Seda; Gök, Özlem; Can, Muhammed İsmail; Parlak, Gozde; Gündoğdu, Ramazan; Özercan, İbrahim Hanifı; Başpınar, Serpil

doi:10.1080/1354750x.2022.2093977

Cited by 5 publications

(1 citation statement)

References 34 publications

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“…It decreased iNOS protein expression, renal myeloperoxidase (MPO) levels, and increased ROS scavenging, inhibiting inflammatory and pro-inflammatory responses, reducing kidney damage and oxidative damage. 9 Prior studies described the protective effects of RJ against cisplatin-induced, 51 , 52 doxorubicin- induced, 53 ethylene glycol-induced, 11 diclofenac-induced, 9 tyrosine kinase inhibitor-Induced, 54 fluoride-induced, 55 valproic acid-induced, 56 and CCl4-induced 57 renal toxicities in rats.…”

Section: Discussionmentioning

confidence: 99%

Royal Jelly, A Super Food, Protects Against Celecoxib-Induced Renal Toxicity in Adult Male Albino Rats

Khalifa,

Eleiwa,

Nazim

2024

Can J Kidney Health Dis

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Background: Celecoxib is a COX-2 nonsteroidal anti-inflammatory drug (NSAID). It is widely used for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Objective: This study aimed to explore the effect of long-term administration of celecoxib on kidney of male albino rats, and to study the potential effect of treatment discontinuation on such tissues. The study also examined the alleged ameliorative effect of royal jelly (RJ). Methods: Fifty, male albino rats were divided into 5 equal groups; 10 each. Group 1: rats received no drug (control group). Group 2: rats received celecoxib (50 mg/kg/day, orally for 30 successive days). Group 3: rats received celecoxib (50 mg/kg/day, orally) and royal jelly (300 mg/kg/day, orally) for 30 successive days. Group 4: rats received celecoxib for 30 successive days, then rats were left untreated for another 30 days. Group 5: rats received celecoxib and RJ for 30 successive days, then rats were left untreated for another 30 days. Results: Long-term celecoxib administration caused significant elevation in kidney function tests, with ameliorative effects of RJ against celecoxib-induced renal toxicity. Conclusion: Long-term celecoxib administration caused renal toxicity in male albino rats, with ameliorative effects of RJ.

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