Protective effect of resveratrol in acute liver damage in rats

Černá, Pavla; Kotyzová, Dana; Eybl, V.

doi:10.1016/j.toxlet.2008.06.599

Cited by 2 publications

(3 citation statements)

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“…We and others demonstrated lipid peroxidation as a biomarker of PQ hepatic toxicity [ 37 , 40 , 41 ]. It was demonstrated that Res can modulate cellular redox in several models of liver injury [ 11 – 13 ] and in subacute PQ toxicity in mice [ 41 ]. Similarly, MK has been shown to diminish oxidative stress markers and enhance antioxidants in rat liver [ 16 , 17 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacokinetic and pharmacodynamic studies have demonstrated that the liver and kidney are main target organs for Res [ 10 ]. Res exerts a hepatoprotective activity in ethanol-, thioacetamide-, and ischemia reperfusion-induced liver damage [ 11 – 13 ]. Also, Res exhibits an immune modulatory effect by suppressing overproduction of inflammatory cytokines like TNF- α , IL-1 β , and IL-6 [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

El-Boghdady

Abdeltawab

Nooh

2017

Oxidative Medicine and Cellular Longevity

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Paraquat (PQ) is one of the most used herbicide worldwide. Its cytotoxicity is attributed to reactive radical generation. Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties. The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before. Therefore, we explored the protective potential of Res and/or MK against PQ hepatic toxicity in a mouse model. Mice were randomly assigned to five groups: group I served as the normal control and group II received a single dose of PQ (50 mg/kg, i.p.). Groups III, IV, and V received PQ plus oral Res (5 mg/kg/day), MK (10 mg/kg/day), and Res/MK combination, respectively. Res and/or MK reduced PQ-induced liver injury, evidenced by normalization of serum total protein, ALT, and AST. Res and/or MK significantly reversed PQ-induced oxidative stress markers glutathione and malondialdehyde. Res and/or MK significantly reduced PQ-induced inflammation reflected in TNF-α levels. Furthermore, Res and/or MK reversed PQ-induced apoptosis assessed by differential expression of p53, Bax, and Bcl-2. Histopathologic examination supported the biochemical findings. Although Res and MK displayed antioxidative, anti-inflammatory, and antiapoptotic activities, their combination was not always synergistic.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

El-Boghdady

Abdeltawab

Nooh

2017

Oxidative Medicine and Cellular Longevity

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“…It prevents and cures cardiovascular diseases and improves microcirculatory disorders [ 20 ]. Resveratrol protects against oxidative stress in cholestasis and exerts hepatoprotective activity against ethanol- and thioacetamide-induced acute and chronic liver damage in rodents [ 21 , 22 ]. Resveratrol at low doses decreases ischemia-reperfusion-induced liver injury and protects hepatocytes against antioxidant defense failure [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury

Roy¹,

Sannigrahi²,

Majumdar³

et al. 2011

Oxidative Medicine and Cellular Longevity

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Recent studies indicate the chemopreventive role of resveratrol in many animal models like ischemia, rheumatoid arthritis, human cancer, and diabetes. The present study was designed to investigate the chemopreventive potential of resveratrol in rat hepatic injury model by carbon tetrachloride. Male Wistar rats were treated with carbon tetrachloride (0.4 g/kg body weight) intraperitoneally daily for 8 weeks. Resveratrol (100 mg/kg, 200 mg/kg body weight) was given orally from first day until the last day of experiment. The investigation assesses the effect of resveratrol on morphological, oxidative status, histopathological, immunohistochemical, and apoptotic analysis in carbon tetrachloride-challenged liver tissue. The study indicated that the inflammatory cytokines TNF-α and IL-6 were profoundly expressed in experimental rats, whereas resveratrol decreases the immunopositivity of TNF-α and IL-6 and restored the altered architectural structure of challenged hepatic tissue. Resveratrol also protects liver cells by suppressing oxidative stress and apoptosis.

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Protective effect of resveratrol in acute liver damage in rats

Cited by 2 publications

References 0 publications

Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury

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