Protective effect of resveratrol against light-induced retinal degeneration in aged SAMP8 mice

Liu, Zhongfan; Wu, Zhengzheng; Li, Jie; Marmalidou, Anna; Zhang, Ruifan; Yu, Man

doi:10.18632/oncotarget.19473

Cited by 13 publications

(4 citation statements)

References 48 publications

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“…Canonical WNT signaling pathway inhibition and many kinds of kinases activation participate in the therapeutic effects [ 28 – 32 ]. Resveratrol treatment decreases a series of cytokines, including decreased IL-6, IFN-γ, TNF-α and Oncostatin M [ 33 , 34 ]. However, exact mechanism of CSCs elimination is rarely reported in resveratrol treated osteosarcoma cells.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

Peng

Jiang

2018

PLoS ONE

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Resveratrol shows potent anti-tumor therapeutic properties in various tumors. However, the exact effect of resveratrol on osteosarcoma cells, especially cancer stem cells, remains unclear. In this study, we examined the effect of resveratrol on osteosarcoma stem cells and explored the underlying molecular mechanisms. Resveratrol inhibited cell viability, self-renewal ability and tumorigenesis of osteosarcoma cells, whereas showed no significant inhibition effects to normal osteoblast cells. Mechanically, resveratrol treatment decreased cytokines synthesis and inhibited JAK2/STAT3 signaling, which was consistent with the decline of cancer stem cells marker, CD133. Exogenous STAT3 activation attenuated the cancer stem cell elimination effects of resveratrol treatment. Our results demonstrated that resveratrol inhibited osteosarcoma cell proliferation and tumorigenesis ability, which was correlated with cytokines inhibition related JAK2/STAT3 signaling blockage. Resveratrol may be a promising therapeutic agent for osteosarcoma management.

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Section: Discussionmentioning

confidence: 99%

Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

Peng

Jiang

2018

PLoS ONE

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“…The Retinari™ treated NFE2L2 KO mice presented with a highly significant increase of scotopic a-and b-wave amplitudes as well as thicker TRT in OCT. A similar increase was observed for photopic ERG b-wave amplitudes. Previous studies reveal that resveratrol increases b-wave amplitudes and contributes to a thicker outer nuclear layer in the aged mouse retina [51,52]. Retinal thickness across the retina has been shown to decrease with age [53], and it is related to AMD progression [54,55].…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol in turn has been linked to antioxidant defence and autophagy enhancement as well as inflammatory response regulation, including CFH-linked complement system modulation [40,68,69]. Furthermore, improved ERG function has also been associated with resveratrol in aged rats [70] and mice with light-induced retinal degeneration [51,52]. All molecular characteristics mentioned above are in logical continuum generating a treadmill worsening the situation on the retina in every turn.…”

Section: Discussionmentioning

confidence: 99%

Pinosylvin extract Retinari™ sustains electrophysiological function, prevents thinning of retina and enhances cellular response to oxidative stress in NFE2L2 knock‐out mice

Tamminen

Koskela

Toropainen

et al. 2022

Acta Ophthalmologica

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Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age-related macular degeneration. We have previously shown an effective age-related macular degeneration disease model in mice with nuclear factor-erythroid 2-related factor-2 (NFE2L2) knockout. We have also shown pinosylvin, a polyphenol abundant in bark waste, to increase human retinal pigment epithelium cell viability in vitro. In this work, the effects of commercial natural pinosylvin extract, Retinari™, were studied on the electroretinogram, optical coherence tomogram, autophagic activity, antioxidant capacity, and inflammation markers. Wild-type and NFE2L2 knockout mice were raised until the age of 14:8 ± 3:8 months. They were fed with either regular or Retinari™ chow (141 ± 17:0 mg/kg/day of pinosylvin) for 10 weeks before the assays. Retinari™ treatment preserved significant retinal function with significantly preserved a-and b-wave amplitudes in the electroretinogram responses. Additionally, the treatment prevented thinning of the retina in the NFE2L2 knockout mice. The NFE2L2 knockout mice showed reduced ubiquitin-tagged protein accumulation in addition to local upregulation of complement factor H and antioxidant enzymes superoxide dismutase 1 and catalase. Therefore, the treatment in the NFE2L2 KO disease model led to reduced chronic oxidative stress and sustained retinal function and morphology. Our results demonstrate that pinosylvin supplementation could potentially lower the risk of agerelated macular degeneration onset and slow down its progression.

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“…Reports have indicated that resveratrol causes a reduction in IOP in steroid-induced ocular hypertension rats [73] and normal normotensive rabbits [74]. Resveratrol has neuroprotective effects through suppressing apoptosis-related molecule activator protein 1 (AP-1) [75] and elevating neuroprotective factors such as leukemia inhibitory factor (LIF), brain-derived neurotrophic factor (BDNF), oncostatin M (OSM), cardiotrophin 1 (CT-1), and cardiotrophin-like cytokine (CLC) [76] in light-induced retinal degeneration mouse models. It has also demonstrated benefits in alleviating hyperglycemia, oxidative biomarkers, vascular damage, anti-inflammation, anti-apoptosis, and reduction in the thickness of retinal layers in DR animal models.…”

Section: Resveratrolmentioning

confidence: 99%

Mitochondrial Dysfunction as a Novel Target for Neuroprotective Nutraceuticals in Ocular Diseases

et al. 2020

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The eyes require a rich oxygen and nutrient supply; hence, the high-energy demand of the visual system makes it sensitive to oxidative stress. Excessive free radicals result in mitochondrial dysfunction and lead to retinal neurodegeneration, as an early stage of retinal metabolic disorders. Retinal cells are vulnerable because of their coordinated interaction and intricate neural networks. Nutraceuticals are believed to target multiple pathways and have shown neuroprotective benefits by scavenging free radicals and promoting mitochondrial gene expression. Furthermore, encouraging results demonstrate that nutraceuticals improve the organization of retinal cells and visual functions. This review discusses the mitochondrial impairments of retinal cells and the mechanisms underlying the neuroprotective effects of nutraceuticals. However, some unsolved problems still exist between laboratory study and clinical therapy. Poor bioavailability and bioaccessibility strongly limit their development. A new delivery system and improved formulation may offer promise for health care applications.

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Protective effect of resveratrol against light-induced retinal degeneration in aged SAMP8 mice

Cited by 13 publications

References 48 publications

Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition

Pinosylvin extract Retinari™ sustains electrophysiological function, prevents thinning of retina and enhances cellular response to oxidative stress in NFE2L2 knock‐out mice

Mitochondrial Dysfunction as a Novel Target for Neuroprotective Nutraceuticals in Ocular Diseases

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