Protective effect of Rehmannia glutinosa on the cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals

Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway

“…Moreover, our results were supported by the traditional usages of RR in alleviating inflammation, as well as the accumulating results of the evidence-based scientific experiments in inflammation area of RR (Kubo et al, 1994;Yu et al, 2006;Liu et al, 2007;Waisundara et al, 2008;Lau et al, 2009Lau et al, , 2012Sung et al, 2011;Baek et al, 2012). In particular, a recent study used human acute monocytic leukemia cell line for the investigation of antiinflammatory effect of RR aqueous crude extract upon the stimulation of advanced glycation end products (Baek et al, 2012).…”

“…Recently, we also revealed that the RR crude extract could significantly and dose-dependently inhibit nitric oxide production (Lau et al, 2012). Indeed, RR crude extract have also been reported to inhibit inflammatory responses in vitro triggered by advanced glycation end products (Baek et al, 2012) and protected against cell damage via scavenging free radicals (Yu et al, 2006). It inhibited inflammation via the reduction of plasma C-reactive protein in diabetic rats (Waisundara et al, 2008), in the development of atopic dermatitis (Sung et al, 2011), and in a rat lung inflammation model (Liu et al, 2007).…”

Rehmannia glutinosa: Review of botany, chemistry and pharmacology

“…The ethanol extract of prepared rehmannia root (SRG) protects cisplatin-induced HEI-OC1 cell from damage through inhibition of lipid peroxidation and scavenging the activities of free radials (Yu et al, 2006b) and the mechanism may be explained, in part, by activation of intracellular antioxidant enzyme systems (Yu et al, 2006c).…”

Cytotoxic, radical scavenging and antimicrobial activities of sesquiterpenoids from the Tahitian liverwort Mastigophora diclados (Brid.) Nees (Mastigophoraceae)

“…This method was used to observe whether these compounds were active or not. In order to determine the IC 50 values of the active compounds, the scavenging activity of pure compounds on 1,1-diphenyl-2-picrylhydrazyl (DPPH, Nacalai Tesque, Kyoto) was measured according to a previous method [24]. Various concentrations of samples (0.1 ml) were mixed with 0.1 ml of 50 lM DPPH solution in 96-well microtiter plates.…”