Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

Chen, Yi-Qin; Chen, Hao-Yin; Tang, Qin-Qi; Li, Yifan; Liu, Xusheng; Lu, Fuhua; Gu, Yue-Yu

doi:10.3389/fphar.2022.968226

Cited by 26 publications

(22 citation statements)

References 93 publications

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“…63,64 Meanwhile a large body of evidence demonstrated the renoprotective effects of quercetin through anti-inflammatory activity and attenuation of apoptosis and fibrosis. [65][66][67] The histopathological finding of the current study greatly supports the biochemical test; where a pronounced improvement has been observed in the combination therapy via clear improvement in the lesion scoring, tissue degeneration, and necrosis.…”

Section: Discussionsupporting

confidence: 78%

Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats

Ali¹,

Ahmed²,

Aziz³

2022

JIR

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The present study was designed to evaluate the possible synergistic effects of telmisartan and quercetin in 5 fluorouracil (5-FU) induced nephrotoxicity in rats. Methodology: Forty male rats were randomly divided into five groups: The negative control group, the positive control group that received 5-FU, the telmisartan group, receiving 10 mg/kg, the quercetin group, receiving 80 mg/kg, and the combination of telmisartan and quercetin group. All the treatments were given orally for 14 days. A single intraperitoneal injection of 5-FU (150 mg/kg) on day 13 of the experiment was given except for the negative control group. On the 15th day after scarification, approximately 5 mL of blood was collected and used for measurement of CBC, urea, creatinine, and uric acid. The kidneys were used for histopathological examination and for the measurement of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), Cystatin C (Cys-C), and total antioxidant capacity (TAOC). Results: The combination therapy significantly attenuated the levels of tissue KIM-1, NGAL, Cys-C, and serum uric acid as well as blood inflammatory markers, Neutrophil/Lymphocyte (NLR), Monocyte/Lymphocyte (MLR), and Platelets/Lymphocyte ratios (PLR), and restored the TAOC. The histopathological findings greatly support the biochemical tests. Conclusion:The results strongly suggest the renoprotective effects of telmisartan and quercetin in combination against the nephrotoxic effect of 5-FU through decreasing the levels of KIM-1, NGAL, and cys-C, and the novel inflammatory markers of kidney injury like NLP, MLR, and PLR, as well as decreasing uric acid and restoring the TAOC. The proposed mechanism could be the additive inhibitory effect on RAS provided by both telmisartan and quercetin.

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Section: Discussionsupporting

confidence: 78%

Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats

Ali¹,

Ahmed²,

Aziz³

2022

JIR

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“…The nephroprotective effects of quercetin have been reported (70 71). The nephroprotective effects of quercetin have been linked to its ability to inhibit the formation of malondialdehyde, scavenge reactive oxygen species, and activate the expression of nuclear factor erythroid 2-related factor 2 and renal heme oxygenase 1, which are important in boosting the production of antioxidant moieties (72).…”

Section: Discussionmentioning

confidence: 99%

Biflavonoid quercetin protects against cyclophosphamide–induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity

Onaolapo

Ojo

Onaolapo

2023

Preprint

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Quercetin's antioxidative properties make it of potential benefit in many clinical conditions where oxidative stress is implicated in the pathological processes. To investigate the possible protective effects of quercetin on neurobehaviour, brain oxidative status, markers of inflammation, neurotransmitter balance and astrocyte immunoreactivity in healthy rats administered cyclophosphamide. Sixty rats were randomly assigned into six groups. Groups A and D served as normal and cyclophosphamide control respectively and were fed standard rat chow, groups B and E were fed quercetin supplemented diet (100 mg/kg of feed), while those in groups C and F were fed quercetin supplemented diet at 200 mg/kg of feed. Animals in group A to C also received intraperitoneal normal saline on days 1 and 2, while those in groups D-F got intraperitoneal cyclophosphamide (150 mg/kg/day on days 1 and 2). Standard diet and quercetin supplemented diet were administered daily for 21 days. At the end of the experimental period, behavioural tests were carried out, following which animals were sacrificed and blood taken for the assessment of biochemical parameters. Organs were either homogenised or processed for histological study. Quercetin mitigated CYP induced weight loss and reduction in food consumption. It also improved total antioxidant capacity while reducing CYP induced lipid peroxidation and biochemical markers of impaired liver function. A reduction in CYP induced increase in urea and creatinine was also observed. Interleukin 10 increased, while the CYP induced increase in interleukin 1 beta and TNF alpha were also mitigated following quercetin administration. Open field exploratory activities and grooming increased with CYP and the lowest dose of quercetin. The anxiolytic effects of quercetin was demonstrable in the elevated plus maze; while its memory-enhancing effects were seen in the Y-maze and radial-arm maze. Finally, quercetin improved acetylcholine dopamine levels and brain-derived neurotropic factor, while reducing serotonin levels and astrocyte immunoreactivity. The results show quercetin s ability to protect against CYP induced changes in rats. They also highlight the possible use of quercetin as a possible adjunct in cancer chemotherapy induced tissue damage. However, further research will be needed to delineate its exact role in cancer chemotherapy.

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“…Quercetin, a Sirtuin-1 and Sirtuin-3 activator, can be widely obtained from many fruits and vegetables, and exhibits wide biological effects in resisting inflammation, diabetic and microbial activities ( Chen et al, 2021 ; Zymone et al, 2022 ). Quercetin also shows renoprotective effects against nephrotoxicity, AKI and CKD ( Lu et al, 2021 ; Chen et al, 2022 ). It has been found quercetin can upregulate PINK1 and Parkin expression via Sirtuin-1 activation.…”

Section: Natural Products For Regulating Mitochondrial Functionmentioning

confidence: 99%

Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

2023

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The patients with kidney diseases are increasing rapidly all over the world. With the rich abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence, renal failure is highly correlated with the breakup of mitochondrial homeostasis. However, the potential drugs targeting mitochondrial dysfunction are still in mystery. The natural products have the superiorities to explore the potential drugs regulating energy metabolism. However, their roles in targeting mitochondrial dysfunction in kidney diseases have not been extensively reviewed. Herein, we reviewed a series of natural products targeting mitochondrial oxidative stress, mitochondrial biogenesis, mitophagy, and mitochondrial dynamics. We found lots of them with great medicinal values in kidney disease. Our review provides a wide prospect for seeking the effective drugs targeting kidney diseases.

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Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

Cited by 26 publications

References 93 publications

Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats

Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats

Biflavonoid quercetin protects against cyclophosphamide–induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity

Natural products for kidney disease treatment: Focus on targeting mitochondrial dysfunction

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