Protective effect of quercetin on liver damage induced by biliary obstruction in rats

Kanter, Mehmet

doi:10.1007/s10735-010-9301-7

Cited by 27 publications

(14 citation statements)

References 39 publications

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“…Persistent cholestasis induces bile duct proliferation and dilation, attracts lowgrade inflammatory infiltration, activates matrix-producing cells, and then leads to periportal and perineoductular fibrosis (Kanter 2010;Desmet et al 1995). In our study, we found both a preventive effect and a therapeutic effect of TQ on BDL-induced hepatic fibrosis.…”

Section: Discussionsupporting

confidence: 61%

Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats

et al. 2012

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The aim of this study was to examine the preventive and therapeutic effects of thymoquinone (TQ) against cholestatic oxidative stress and liver damage in common bile duct ligated rats. A total of 24 male Sprague-Dawley rats were divided into three groups: control, bile duct ligation (BDL) and BDL + received TQ; each group contain 8 animals. The rats in TQ treated groups were given TQ (50 mg/kg body weight) once a day orally for 2 weeks starting 3 days prior to BDL operation. To date, no more biochemical and histopathological changes on common bile duct ligated rats by TQ treatment have been reported. The application of BDL clearly increased the tissue hydroxyproline (HP) content, malondialdehyde (MDA) levels and decreased the antioxidant enzyme [superoxide dismutase (SOD), glutathione peroxidase (GPx)] activities. TQ treatment significantly decreased the elevated tissue HP content, and MDA levels and raised the reduced of SOD, and GPx enzymes in the tissues. The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells, and neutrophil infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with TQ attenuated alterations in liver histology. The immunopositivity of alpha smooth muscle actin and proliferating cell nuclear antigen in BDL were observed to be reduced with the TQ treatment. The present study demonstrates that oral administration of TQ in bile duct ligated rats maintained antioxidant defenses and reduces liver oxidative damage and ductular proliferation. This effect of TQ may be useful in the preservation of liver function in cholestasis.

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Section: Discussionsupporting

confidence: 61%

Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats

et al. 2012

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“…It is well known that oxidative stress plays an important role in the development of liver diseases ; therefore, the antioxidant properties of quercetin may be responsible for the beneficial effects observed in this report and others . Interestingly, here we observed that quercetin is 20 times less effective than trolox to scavenge DPPH, but trolox is as effective as quercetin to prevent fibrosis at the same dose .…”

Section: Discussionsupporting

confidence: 58%

Quercetin reverses experimental cirrhosis by immunomodulation of the proinflammatory and profibrotic processes

Casas‐Grajales

Vázquez-Flores

Ramos‐Tovar

et al. 2017

Fundamemntal Clinical Pharma

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The ability of quercetin to reverse an established cirrhosis has not yet been investigated. Therefore, the aim of this study was to examine the efficacy of this flavonoid in reversing experimental cirrhosis. Cirrhosis was induced by intraperitoneal administration of TAA (200 mg/kg of body weight) three times per week for 8 weeks or by intraperitoneal petrolatum-CCl (400 mg/kg of body weight) administration three times per week for 8 weeks. To determine the capacity of quercetin to prevent liver fibrosis, the flavonoid (50 mg/kg of body weight, p.o.) was administered daily to rats during the CCl or TAA treatment. To evaluate the ability of quercetin to reverse the previously induced cirrhosis, we first treated rats with CCl for 8 weeks, as previously described and then the flavonoid was administered for four more weeks. We found that the liver anti-inflammatory and antinecrotic effects of quercetin are associated with its antioxidant properties, to the ability of the flavonoid to block NF-κB activation and in consequence to reduce cytokine IL-1. The ability of quercetin to reverse fibrosis may be associated with the capacity of the flavonoid to decrease TGF-β levels, hepatic stellate cell activation, and to promote degradation of the ECM by increasing metalloproteinases. The main conclusion is that quercetin, in addition to its liver protective activity against TAA chronic intoxication, is also capable of reversing a well-stablished cirrhosis by blocking the prooxidant processes and by downregulating the inflammatory and profibrotic responses.

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“…Our data are corroborated by previous studies reported by other investigators on BDL-induced hepatic fibrosis in animals (Kanter, 2010;Oguz et al, 2012;Tomur et al, 2011). In this study, we demonstrated histologically that the melatonin significantly reduced fibrosis in BDL rats.…”

Section: Discussionsupporting

confidence: 93%

Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats

et al. 2012

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The goal of this study was to evaluate the possible protective effects of melatonin against cholestatic oxidative stress, liver damage and hepatocyte apoptosis in the common rats with bile duct ligation (BDL). A total of 24 male Wistar albino rats were divided into three groups: control, BDL and BDL + received melatonin; each group contains eight animals. Melatonin-treated BDL rats received daily melatonin 100 mg/kg/day via intraperitoneal injection. The application of BDL clearly increased the malondialdehyde (MDA) levels and decreased the superoxide dismutase (SOD) and glutathione (GSH) activities. Melatonin treatment significantly decreased the elevated tissue MDA levels and increased the reduced SOD and GSH enzyme levels in the tissues. The changes demonstrate that the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells and neutrophil infiltration into the widened portal areas as observed in the BDL group. The data indicate that melatonin attenuates BDL-induced cholestatic liver injury, bile duct proliferation and fibrosis. The α-smooth muscle actin (α-SMA) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells in the BDL were observed to be reduced with the melatonin treatment. These results suggest that administration of melatonin is a potentially beneficial agent to reduce liver damage in BDL by decreasing oxidative stress.

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Protective effect of quercetin on liver damage induced by biliary obstruction in rats

Cited by 27 publications

References 39 publications

Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats

Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats

Quercetin reverses experimental cirrhosis by immunomodulation of the proinflammatory and profibrotic processes

Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats

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