Protective effect of propolis on methotrexate-induced kidney injury in the rat

Ulusoy, Hasan; Öztürk, İsmet; Sönmez, Mehmet Fatih

doi:10.3109/0886022x.2016.1158070

Cited by 35 publications

(23 citation statements)

References 26 publications

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“…The increased level of its cellular metabolites could induce oxidative and inflammatory tissue damages [ 37 ], which could be demonstrated in the form of histopathological changes [ 38 ] and elevation of serum liver enzymes [ 39 ]. Moreover, MTX metabolites were found to precipitate in renal tubules, causing marked nephrotoxicity in rats [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Diosmin Attenuates Methotrexate‐Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

Abdel-Daim

Khalifa

Abushouk

et al. 2017

Oxidative Medicine and Cellular Longevity

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The current study was designed to investigate the beneficial role of diosmin, a biologically active flavonoid, against methotrexate- (MTX-) induced hepatic, renal, and cardiac injuries in mice. Male Swiss albino mice received a single intraperitoneal injection of MTX (at 20 mg/kg, body weight) either alone or in combination with oral diosmin (at 50 or 100 mg/kg body weight, for 10 days). Serum was used to evaluate tissue injury markers, while hepatic, renal, and cardiac tissue samples were obtained for determination of antioxidant activity as well as histopathological examination. Diosmin treatment ameliorated the MTX-induced elevation of serum alkaline phosphatase, aminotransferases, urea, creatinine, lactate dehydrogenase, and creatine kinases as well as plasma proinflammatory cytokines (interleukin-1-beta, interleukin-6, and tumor necrosis factor-alpha). Additionally, both diosmin doses significantly reduced tissue levels of malondialdehyde and nitric oxide and increased those of glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, superoxide dismutase, and catalase, compared to the MTX-intoxicated group. Histopathological examination showed that diosmin significantly minimized the MTX-induced histological alterations and nearly restored the normal architecture of hepatic, renal, and cardiac tissues. Based on these findings, diosmin may be a promising agent for protection against MTX-induced cytotoxicity in patients with cancer and autoimmune diseases.

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Section: Discussionmentioning

confidence: 99%

Diosmin Attenuates Methotrexate‐Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

Abdel-Daim

Khalifa

Abushouk

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Propolis has also been found to be effective in protecting against methotrexate-induced kidney injury in rats 227 . The effect of propolis on mitochondrial biogenesis in CKD remains to be determined.…”

Section: Nutrients That Target Mitochondrial Dysfunctionmentioning

confidence: 99%

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

et al. 2020

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stress and premature ageing are common features of the uremic phenotype.• The foodome -defined as the pool of all compounds present in a food sample and/or in a biological system interacting with the investigated food -can be implicated in the modulation of CKD complications.• Imbalance in the relative diversity of the gut microbiota has been studied extensively in CKD due its links with inflammation and cardiovascular risk. In this direction, researchers are evaluating the effects of pre-, pro-and synbiotics and many others food components like polyphenol-rich foods, sugar, proteins, etc. on both the modulation of the diversity of the gut microbiota and reduction in the levels of uremic toxins .• The use of bioactive compounds, found in curcumin, broccoli sprouts, berries, propolis, etc. may be valid nutritional therapeutic agents to modulate the expression of pro-inflammatory transcription factors, such as Nrf2, NF-kB and the inflammasome.• Senotherapeutic dietary compounds may mitigate the effects of a dysregulated ageing process in CKD and associated complications. including disturbed mitochondrial metabolism.Onion and garlic -may decrease NLRP3 activation Spinach -rich in betaine Green leafy vegetables -rich in folate Cruciferous vegetables, -rich in sulforaphane -may decrease NLRP3 activation, Nrf2 activators Some vegetables, such as spinach, broccoli, potatoes, cucumbers, green leafy -rich in potassium.

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“…In addition, we suggest that a more detailed analysis, including dosage, duration and timing of administration also should be performed. Furthermore, we also speculated that there was the possibility that crude honey, including various honey products such as propolis and bee pollen, is more closely associated with nephroprotective effects more than pure RJ because these products exert protective effects on kidney function [ 61 , 62 ]. Indeed, as mentioned above, animal experiments also showed that the nephroprotective effects of RJ were lower than those of honey [ 49 ].…”

Section: Activity Of Royal Jelly Against Cancer Therapy-induced Tomentioning

confidence: 99%

Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

Miyata

Sakai

2018

IJMS

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Royal jelly (RJ) is a glandular secretion produced by worker honeybees and is a special food for the queen honeybee. It results in a significant prolongation of the lifespan of the queen honeybee compared with the worker honeybees through anti-inflammatory, anti-oxidant and anti-microbial activities. Consequently, RJ is used as cosmetic and dietary supplement throughout the world. In addition, in vitro studies and animal experiments have demonstrated that RJ inhibits cell proliferation and stimulates apoptosis in various types of malignant cells and affects the production of various chemokines, anti-oxidants and growth factors and the expression of cancer-related molecules in patients with malignancies, especially in patients treated with anti-cancer agents. Therefore, RJ is thought to exert anti-cancer effects on tumor growth and exhibit protective functions against drug-induced toxicities. RJ has also been demonstrated to be useful for suppression of adverse events, the maintenance of the quality of life during treatment and the improvement of prognosis in animal models and patients with malignancies. To understand the mechanisms of the beneficial effects of RJ, knowledge of the changes induced at the molecular level by RJ with respect to cell survival, inflammation, oxidative stress and other cancer-related factors is essential. In addition, the effects of combination therapies of RJ and other anti-cancer agents or natural compounds are important to determine the future direction of RJ-based treatment strategies. Therefore, in this review, we have covered the following five issues: (1) the anti-cancer effects of RJ and its main component, 10-hydroxy-2-decenoic acid; (2) the protective effects of RJ against anti-cancer agent-induced toxicities; (3) the molecular mechanisms of such beneficial effects of RJ; (4) the safety and toxicity of RJ; and (5) the future directions of RJ-based treatment strategies, with a discussion on the limitations of the study of the biological activities of RJ.

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Protective effect of propolis on methotrexate-induced kidney injury in the rat

Cited by 35 publications

References 26 publications

Diosmin Attenuates Methotrexate‐Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

Diosmin Attenuates Methotrexate‐Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

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