Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion

Menyiy, Naoual El; Waili, Noori Al; Bakour, Meryem; Al-Waili, Hamza; Lyoussi, Badiâa

doi:10.1016/j.arcmed.2016.12.010

Cited by 40 publications

(36 citation statements)

References 44 publications

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“…Because we did not profile for any drug-metabolizing enzymes in the differentiated cells, we cannot conclusively determine the reason why our stem cell-derived model could not detect APAP nephrotoxicity. In the case of EG, it is initially metabolized by P450 enzymes in the liver, resulting in the formation of oxalic acid, which concentrates in the kidney and precipitates as calcium oxalate monohydrate crystals causing nephrotoxicity; this process would not be expected in an in vitro kidney model (El Menyiy et al, 2016). Our results are consistent with previous studies using primary PTCs that did not detect APAP or EG based nephrotoxicity either (Li et al, 2013(Li et al, , 2014Adler et al, 2016).…”

Section: Discussionsupporting

confidence: 90%

Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies

et al. 2018

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Current in vitro models for identifying nephrotoxins are poorly predictive. We differentiated human pluripotent stem cells (hPSCs) into three-dimensional, multicellular structures containing proximal tubule cells (PTCs) and podocytes and evaluated them as a platform for predicting nephrotoxicity. The PTCs showed megalin-dependent, cubilin-mediated endocytosis of fluorescently labeled dextran and active gamma-glutamyl transpeptidase enzymes. Transporters from both the ATP-binding cassette (ABC) and the solute carrier (SLC) families were present at physiological levels in the differentiated cells, but important renal transporters such as organic anion transporter 1 (OAT1), OAT3, and organic cation transporter 2 (OCT2) were present only at lower levels. Radioactive uptake studies confirmed the functional activity of organic cation transporter, novel, type 2 (OCTN2), organic anion transporter polypeptide 4C1 (OATP4C1), and OCTs/multidrug and toxin extrusion proteins (MATEs). When treated with 10 pharmacologic agents as a test of the platform, the known nephrotoxic compounds were distinguished from the more benign compounds by an increase in tubular (PTC, kidney injury molecule 1 (KIM-1), and heme oxygenase 1 (HO-1)) and glomerular (nephrin [NPHS1]/Wilms tumor protein [WT1]) markers associated with nephrotoxicity, and we were able to distinguish the type of nephrotoxin by examining the relative levels of these markers. Given the functions demonstrated and with improved expression of key renal transporters, this hPSC-derived in vitro kidney model shows promise as a platform for detection of mechanistically different nephrotoxins.

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Section: Discussionsupporting

confidence: 90%

Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies

et al. 2018

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“…Urinary obstruction owing to massive stones or crystals cause declined glomerular filtration, leading to gathering of nitrogenous contaminants such as creatinine and uric acid in blood [21,22]. The present study is in accordance with this information and showed that EG exposure increased serum levels of creatinine and uric acid.…”

Section: Discussionsupporting

confidence: 90%

The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

KELEŞ¹,

Şen²,

Ertaş³

et al. 2020

jrp

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Nephrolithiasis is common urological problem and stone formation has multiple underlying pathogenetic factors. We investigated the possible preventive and therapeutic effects of Urtica dioica ethanol extract (UD) on ethylene glycol-induced nephrolithiasis model in rats. Sprague-Dawley rats were divided into four groups (n = 10). The control group was given normal drinking water for 8 weeks and was administered vehicle by gastric gavage. Stone formation was induced by adding 0.75% ethylene glycol (EG) to their drinking water. UD (700 mg/kg) was given orally for 8 weeks to the preventive group and for last 4 weeks to the treatment group, respectively. At the end of the experiment, urine, blood samples and kidney tissues were obtained. In 24-hour urine samples, calcium and citrate levels were decreased and oxalate levels were increased in EG group whereas UD treatment groups reversed these parameters back to control levels. In addition, serum levels of creatinine and urea were increased in EG group, while UD significantly reduced these parameters. Malondialdehyde, 8-hydroxydeoxyguanosine and tumor necrosis alpha levels, and caspase-3 and N-acetyl-β-glucosaminidase activities were elevated in EG group and showed a decrease in UD treated groups. Glutathione level was decreased in EG group, whereas it was increased in UD preventive group. Histological examination showed an improvement in UD treated groups. Our results suggest that UD is effective both in prevention and treatment for kidney stones. The mechanism underlying this effect may be the antioxidant effect of UD and the effect on the concentration of stone-forming components in the urine.

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“…El-Guendouz et al [297] have also explored the diuretic effect of propolis on Wistar rats clinically healthy and supported the results of El Menyiy et al [295] affirming that propolis may be used in acute or chronic kidney pathological entities where oxidative process plays a major role in the pathogenesis. In addition, El-Guendouz et al [22] have synthesized magnetite nanoparticles using propolis and exanimated its effect on inhibition of adherence of methicillin resistant strains of S. aureus using a catheter for medical application.…”

Section: Application In Medicine Pharmacy and Bio-allied Sciencementioning

confidence: 73%

“…[294] Hydro-alcoholic extracts of propolis from Salé region in Morocco, have been investigated for its protective effect in proteinuria, crystalluria, nephrotoxicity and hepatotoxicity induced by ethylene glycol ingestion. [295] The authors have also evaluated the protective effect of hydro-ethanolic extract of propolis against paracetamol-induced liver and kidney damage in rats models. [296] The results of this application joined the previous results cited in this review, for the potential protective effect of propolis on hepatotoxicity and nephrotoxicity, moreover, its showed that propolis from Morocco has potential to treat and prevent urinary calculus, crystalluria and proteinuria.…”

Section: Application In Medicine Pharmacy and Bio-allied Sciencementioning

confidence: 99%

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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This review updates the information upon the chemical composition of propolis from all Mediterranean countries as well as their biological properties and applications. The non‐volatile fraction of propolis was characterized by the presence of phenolic acids and their esters and flavonoids. Nevertheless, in some countries, diterpenes were also present: Sicily (Italy), Croatia, Malta, Creta (Greece), Turkey, Cyprus, Egypt, Libya, Algeria and Morocco. The volatile fraction of propolis was characterized by the presence of benzoic acid and its esters, mono‐ and sesquiterpenes, being the oxygenated sesquiterpene β‐eudesmol characteristic of poplar propolis, whereas the hydrocarbon monoterpene α‐pinene has been related with the presence of conifers. Regardless the chemical composition, there are common biological properties attributed to propolis. Owing to these attributes, propolis has been target of study for applications in diverse areas, such as food, medicine and livestock.

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Protective Effect of Propolis in Proteinuria, Crystaluria, Nephrotoxicity and Hepatotoxicity Induced by Ethylene Glycol Ingestion

Cited by 40 publications

References 44 publications

Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies

Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies

The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

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