Protective Effect of Procyanidin-Rich Grape Seed Extract against Gram-Negative Virulence Factors
Roberta Maria Nicolosi,
Graziana Bonincontro,
Elena Imperia
et al.
Abstract:Biofilm formation and lipopolysaccharide (LPS) are implicated in the pathogenesis of gastrointestinal (GI) diseases caused by Gram-negative bacteria. Grape seeds, wine industry by-products, have antioxidant and antimicrobial activity. In the present study, the protective effect of procyanidin-rich grape seed extract (prGSE), from unfermented pomace of Vitis vinifera L. cv Bellone, on bacterial LPS-induced oxidative stress and epithelial barrier integrity damage has been studied in a model of Caco-2 cells. The … Show more
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