“…Pre-infarction angina in patients decreases IS ( Andreotti et al, 1996 ; Iglesias-Garriz et al, 2001 ; Kloner et al, 1998 ; Lønborg, Kelbæk, Vejlstrup, Bøtker, Kim, Holmvang, Jørgensen, Helqvist, Saunamäki, Thuesen, et al, 2012 ; Reiter et al, 2013 ) and no-reflow ( Karila-Cohen et al, 1999 ; Colonna et al, 2002 ; Niccoli et al, 2014 ), and it improves patients’ prognosis ( Lorgis et al, 2012 ; Herrett et al, 2014 ; Schmidt et al, 2015 ). However, the protection by pre-infarction angina is attenuated by nonmodifiable risk factors, such as age ( Ishihara et al, 2000 ); modifiable risk factors, such as smoking; and comorbidities, such as dyslipidemia ( Niccoli et al, 2014 ). Also, the time interval between the prodromal angina and the onset of AMI is decisive and was between 1 ( Kloner et al, 1998 ; Ishihara et al, 2000 ; Iglesias-Garriz et al, 2001 ; Reiter et al, 2013 ) and 7 ( Karila-Cohen et al, 1999 ; Colonna et al, 2002 ; Lønborg Kelbæk, Vejlstrup, Bøtker, Kim, Holmvang, Jørgensen, Helqvist, Saunamäki, Thuesen, et al, 2012 ; Herrett et al, 2014 ) or 14 days ( Schmidt et al, 2015 ) when resulting in a clinical benefit.…”