Protective Effect of Pomegranate Peel Extract against DiabeticInduced Renal Histo-pathological Changes in Albino Rats

Ahmed, Ahmed T. G.; Belal, Saied K. M.; Gaber, A.H.; Salem, Elsaid

doi:10.9790/0853-1310594105

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Table 7 show a significant decrease in serum urea, creatinine and uric acid levels in rats treated with MPE in diabetic rats (group 4) and hyperlipidemic rats (group 7) when compared with diabetic control and hyperlipidemic control rats. MPE alleviated the diabetic renal complication by glomerular tuft and tubular epithelium cells as concluded by Ahmed et al (2014).…”

Section: Kidney Function Biomarkersmentioning

confidence: 78%

“…Diabetes mellitus (DM), is an abnormally elevated blood sugar level resulting disorder in insulin production and lead to complications in many body systems, significantly participate to cardiovascular morbidity and mortality (Ahmed, Belal, & Salem, 2014;Jyothsna, 2017). Complications of diabetes include blindness, strokes, kidney, and heart failure.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

El-Hadary

Ramadan

2019

J Food Biochem

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This work is aimed to evaluate phenolics composition, and in vitro antioxidant activities of hydro‐methanol pomegranate (Punica granatum L.) peel extract (MPE). In addition, the antihyperglycemic, hypolipidemic, and hepatoprotective effect of MPE in Wister albino rats was compared with standard drugs (glibenclamide and atorvastatin). Total phenolic content and total flavonoid contents in MPE (mg g−1) accounted for 188.9 as GAE and 13.95 as QE, respectively. Phenolic and flavonoids compounds in MPE analyzed by HPLC and revealed the presence of 23 phenolic compounds and 20 flavonoid compounds. For in vivo experiment, 56 rats were distributed into 8 groups. Group 1 was the normal control, while group 2 contained rats orally administrated with 200 mg kg−1 MPE daily. Group 3 contained diabetic rats (induced with a single dose of 100 mg/kg b.w. alloxan). Group 4 contained diabetic rats administered daily with 200 mg/kg MPE. Group 5 contained diabetic rats administered orally with a glibenclamide (standard drug for diabetic) at 10 mg/kg daily. Group 6 fed with high fat diet (HFD). Group 7 contained HFD‐rats administered orally with 200 mg/kg MPE daily. Group 8 contained HFD‐rats administered orally with atorvastatin (used to lower LDL‐cholesterol (LDL‐C) and fats and to raise HDL‐cholesterol (HDL‐C) in the blood) at 10 mg/kg daily. The study lasted for 56 days. Administration with MPE 200 mg/kg to both diabetic and hyperlipidemic rats significantly decreased blood glucose, HbA1c, total lipid, total cholesterol, LDL‐C, and very low density lipoprotein cholesterol levels, while increased high density lipoprotein cholesterol levels, as well as improved liver and kidney functions, compared with glibenclamide and atorvastatin effects. Practical applications Pomegranate peel, constituted about 50% of fruit fresh weight, is rich in bioactive compounds with potent health‐promoting activities. The results of the current study stated that MPE is rich in phenolics and flavonoids with powerful antioxidant potential. In addition, MPE showed antihyperglycemic and antihyperlipidemic activities due to the strong antiradical action via its antioxidant compounds. MPE enhanced liver and kidney functions when compared to standard drugs in diabetic and hyperlipidemic rats. MPC could be used as a natural material to develop diabetic and hyperlipidemic drugs.

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Section: Kidney Function Biomarkersmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

El-Hadary

Ramadan

2019

J Food Biochem

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Histological, Immunohistochemical and Biochemical Study of Experimentally Induced Fatty Liver in Adult Male Albino Rat and the Possible Protective Role of Pomegranate

Hassan

Soliman

Okasha

et al. 2017

Journal of Microscopy and Ultrastructure

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Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats

M. Ezz,

ALheeti,

Hasan

et al. 2023

Biomed. Pharmacol. J.

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Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with a few intricacies like hyperlipidemia. The current study aimed to study the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. A total of 70 male rats were divided into 7 groups (normal rats treated with the pomegranate peel extract and L-carnitine; rats given a high-fat diet to cause hyperlipidemia, this rats given low-dose intraperitoneal streptozotocin injections to cause type II diabetes; diabetic rats given PPE and L-carnitine orally every day for 12 weeks. Measurements of body mass, blood sugar, lipid profile and antioxidant enzyme activity were made.Results: The treatment group that received PPE + L-carnitine showed a significant decrease in weight, blood glucose, cholesterol, triglycerides and low-density lipoprotein were significantly reduced, while high-density lipoprotein levels were significantly increased. Superoxide dismutase levels were increased, catalase and Nuclear Factor Erythroid-derived 2 (Nfe2) in diabetic rats treated with PPE and L-carnitine, while Malondialdehyde levels decreased significantly. According to the results of the study, PPE and L-carnitine had significant anti-hyperglycemic, hypolipidemic, and antioxidant benefits after 12 weeks of treatment in streptozotocin-induced diabetic rats.

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Protective Effect of Pomegranate Peel Extract against DiabeticInduced Renal Histo-pathological Changes in Albino Rats

Cited by 3 publications

References 41 publications

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

Histological, Immunohistochemical and Biochemical Study of Experimentally Induced Fatty Liver in Adult Male Albino Rat and the Possible Protective Role of Pomegranate

Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats

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