Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay

Safonova, E. A.; Lopatina, K. A.; Вычужанина, А. В.; Mashanova, V. A.; Разина, Т. Г.; Borovskaya, T. G.; Зуева, Е. П.; Гурьев, А. М.; Belousov, M. V.

doi:10.1007/s10517-018-4317-1

Cited by 3 publications

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“…It is worth noting that polysaccharides do not stimulate the growth of tumor and metastasis ( Safonova et al , 2019 ). The authors also proved that the genic protective properties of these polysaccharides in bone marrow cells and small intestinal epithelium of C57Bl/6 mice during polychemotherapy ( Safonova et al , 2018b ). Hence, coltsfoot, polysaccharides may be a promising agent for the generation of a new medicinal substance about polychemotherapy ( Safonova et al , 2018b ).…”

Section: Pharmacologymentioning

confidence: 90%

“…Other metabolites belonging to coltsfoot, including sterols, amino acids, organic acid ( Zhi et al , 2012 ) and polysaccharides have also been documented in the coltsfoot ( Safonova et al , 2018b ). A chemical investigation of the MeOH extracts of coltsfoot leaves by enzyme assay-guided fractionation of the extract resulted in the isolation of two glucosinates, (139 and 140) for the first time ( Kuroda et al , 2016 ).…”

Section: Phytochemical Aspectmentioning

confidence: 99%

“…Undoubtedly, chemotherapy causes damaging effects both in tumor and in healthy cells with high proliferative activity ( Safonova et al , 2018b ). It was interesting to see that polysaccharides from coltsfoot were employed to treat the side effects caused by chemotherapy.…”

Section: Pharmacologymentioning

confidence: 99%

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A review of the ethnobotanical value, phytochemistry, pharmacology, toxicity and quality control of Tussilago farfara L. (coltsfoot)

Chen

Dong

Quan

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Tussilago farfara L. (commonly called coltsfoot), known as a vital folk medicine, have long been used to treat various respiratory disorders and consumed as a vegetable in many parts of the world since ancient times. Aim of the review This review aims to provide a critical evaluation of the current knowledge on the ethnobotanical value, phytochemistry, pharmacology, toxicity and quality control of coltsfoot, thus provide a basis for further investigations. Materials and methods A detailed literature search was obtained using various online search engines (e.g. Google Scholar, Web of Science, Science Direct, Baidu Scholar, PubMed and CNKI). Additional information was sourced from ethnobotanical literature focusing on Chinese and European flora. The plant synonyms were validated by the database ‘The Plant List’ ( www.theplantlist.org ). Results Coltsfoot has diverse uses in local and traditional medicine, but similarities have been noticed, specifically for relieving inflammatory conditions, respiratory and infectious diseases in humans. Regarding its pharmacological activities, many traditional uses of coltsfoot are supported by modern in vitro or in vivo pharmacological studies such as anti-inflammatory activities, neuro-protective activity, anti-diabetic, anti-oxidant activity. Quantitative analysis (e.g. GC-MS, UHPLC-MRM HR ) indicated the presence of a rich (>150) pool of chemicals, including sesquiterpenes, phenolic acids, flavonoids, chromones, pyrrolizidine alkaloids (PAs) and others from its leaves and buds. In addition, adverse events have resulted from a collection of the wrong plant which contains PAs that became the subject of public concern attributed to their highly toxic. Conclusions So far, remarkable progress has been witnessed in phytochemistry and pharmacology of coltsfoot. Thus, some traditional uses have been well supported and clarified by modern pharmacological studies. Discovery of therapeutic natural products and novel structures in plants for future clinical and experimental studies are still a growing interest. Furthermore, well-designed studies in vitro particularly in vivo are required to establish links between the traditional uses and bioactivities, as well as ensure safety before clinical use. In addition, the good botanical identification of coltsfoot and content of morphologically close species is a precondition for quality supervision and control. Moreover, strict quality control measures are required in the studies investigating any aspect of the pharmacology and chemistry of coltsfoot.

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Section: Pharmacologymentioning

confidence: 90%