Protective effect of oxytocin on vincristine-induced gastrointestinal dysmotility in mice
Shuang Li,
Yao Shi,
Jianchun Zhu
et al.
Abstract:Aims: Vincristine (VCR), an antineoplastic drug, induces peripheral neuropathy characterized by nerve damage, limiting its use and reducing the quality of life of patients. VCR causes myenteric neuron damage, inhibits gastrointestinal motility, and results in constipation or paralytic ileus in patients. Oxytocin (OT) is an endogenous neuropeptide produced by the enteric nerve system, which regulates gastrointestinal motility and exerts neuroprotective effects. This study aimed to investigate whether OT can imp… Show more
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