Protective Effect of Orally Administrated Dandelion Against Carrageenan-induced Ankle Arthritis in Rats

Sur, Bong Jun; Koh, Yoon Jeong; Choi, Hee Don; Shim, Insop; Lee, Hyejung; Hahm, Dae Hyun

doi:10.5607/en.2008.17.2.63

Cited by 1 publication

(1 citation statement)

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“…Arthritis is a chronic, infammatory disease, systemic that causes many joints in the body to become tender and swollen, resulting in the joints becoming stif and very painful. In the case of this study, to investigate the degree of edema caused by the local induction of arthritic infammation, the variation in paw thickness was measured for 24 h and then for 10 days [69]. Carrageenan is generally used to induce various types of infammation, paw edema, and acute monoarthritis in numerous animal studies.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Anti-Inflammatory Properties of the Hydroethanolic Extract of the Roots of Vernonia guineensis (Asteraceae)

Nana

Mimb

Atsamo

et al. 2023

International Journal of Inflammation

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In traditional Cameroonian medicine, to relieve many inflammations, parts of Vernonia guineensis, are very widely used. This study considered the evaluation of acute toxicity and anti-inflammatory properties of the hydroethanolic extract of the roots of Vernonia guineensis. In an acute toxicity study, 250, 2500, and 5000 mg/kg were administered orally to mice in a single dose, and general behavior, adverse effects, and mortality were monitored. In vitro and in vivo anti-inflammatory tests were performed, and then histological, serum, hematological, and oxidative stress parameters have been evaluated. In an acute toxicity, all groups revealed neither mortality nor any significant alteration in behavior; only drowsiness, sedation, and lethargy were observed at 5000 mg/kg. For in vitro tests, the extract inhibited anti-inflammatory activity. In the formalin test, at 250 mg/kg, the extract inhibited edema with a percentage of 56.41% (4th hour) in an acute treatment and 74.44% (10th day). Joint edema was reduced by 67.24% (24th hour) in a single treatment and by 74.25% (7th day) in repeated treatment. The extract caused an increase in red blood cell, hemoglobin, and serum protein levels and reduced the white blood cells as well as the activities of alkaline phosphatase and alanine aminotransferase. The extract modulated oxidative stress parameters in the brain, spinal cord, liver, and kidneys. The extract protected the joint by reducing the bone and cartilage erosion. The present work highlights the anti-inflammatory, antioxidant, and antianemic properties of the hydroethanolic extract of the roots of Vernonia guineensis, which supports its empirical use in traditional medicine for the treatment of inflammatory pathologies.

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Section: Discussionmentioning

confidence: 99%