Protective Effect of Omega-3 Fatty Acids in Fish Consumption Against Breast Cancer in Asian Patients: A Meta-Analysis

Abstract

Objective:This systematic review and meta-analysis was performed to determine the protective effect of omega-3 fatty acids in fish consumption against breast cancer in Asian patients. Methods:The authors conducted a meta-analysis of published research articles on protective effect of omega-3 fatty acids in fish consumption against breast cancer in Asian patients published between January 2000 and July 2018 in online database of PubMed, ProQuest and EBSCO. Pooled odds ratios (OR) were calculated by using fixed and random-effect models. Publication bias was visually evaluated by using funnel plots and statistically assessed in Egger’s and Begg’s tests. Data were processed by Review Manager 5.3 (RevMan 5.3) and Stata version 14.2 (Stata Corporation). Results:This study reviewed 913 articles. There were 11 studies which conducted systematic review then continued by meta-analysis of relevant data with total number of samples were 130,365 patients. The results showed there was protective effect of omega-3 fatty acids in fish consumption against breast cancer in Asian patients (OR = 0.80 [95% CI 0.73-0.87, p <0.00001]). There was not any study with significant publication bias included.Conclusion:This analysis confirmed the protective effect of omega-3 fatty acids in fish consumption against breast cancer in Asian patients.

Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

“…No associations were found between consumption of eicosapentaenoic acid, docosahexaenoic, or α‐linolenic acid and BC incidence. Studies with Eastern Asian populations confirmed the association between higher consumption of fish n ‐3 PUFA and reduced BC incidence (RR = 0.80; Nindrea et al, ).…”

“…Two studies included in this review demonstrated a positive association between higher consumption of PUFA and risk of post‐menopausal BC, however, these studies did not differentiate between n ‐3 and n ‐6 PUFA in the analysis. On the other hand, higher consumption of marine n ‐3 PUFA has been shown to be inversely associated with BC incidence (Nindrea et al, ; Zheng et al, ). Moreover, a higher ratio of n ‐3/ n ‐6 is also considered to be protective (Alarcon de la Lastra, Barranco, Motilva, & Herrerias, ; Yang et al, ).…”

Dietary Fibre Protective against Colorectal Cancer Patients in Asia: A Meta-Analysis

“…High fibre intakes, particularly from cereals or grains and fruit, are associated with a reduced risk of incident colorectal adenoma and cancer [8], [12], [23]. Prospective study within a population-based screening trial suggests that individuals consuming the highest intakes of dietary fibre have reduced risks of incident colorectal adenoma and distal colon cancer and that this effect of dietary fibre, particularly from cereals and fruit, may begin early in colorectal carcinogenesis [11], [24].…”

The Potential for Plant-Based Diets to Promote Health Among Blacks Living in the United States

“…For example, the role that omega-3 fats in fish oil play in tumor suppression continues to be investigated, and more interventions are needed on omega-3 dosage and subtypes (DHA versus EPA) [47]. Further, European and Asian cohorts have recorded possible risk reduction of colorectal and breast cancers with omega-3 fish consumption [48,49], but more research is needed in Blacks. Brasky et al found no significant association between omega-3 and fish consumption and endometrial cancer risk in 47,602 African American women, although non-significant hazard ratios were more favorable among normal weight women (HR = 0.53; 95% CI = 0.18, 1.58) than in overweight women (HR = 0.88; 95% CI = 0.56, 1.31) [50].…”