Protective effect of oat (
            <i>Avena sativa</i>
            ) bran extracts on acute hepatic liver damage in mice

Debnath, Trishna; Kim, Min Jung; Das, Gitishree; Nath, Narayan Chandra Deb; Lee, Kwang‐Geun

doi:10.1080/09540105.2018.1541169

Cited by 9 publications

(5 citation statements)

References 38 publications

(38 reference statements)

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“…BaP could produce a variety of ROS during the metabolism, the excessive ROS in the body would be involved in the pathogenesis of liver tissue and cause changes in the antioxidase activities (Debnath, Kim, Das, Nath, & Lee, 2019). MDA is the product of lipid peroxidation (Zhuang et al, 2016), H 2 O 2 is produced as a natural byproduct of the normal of oxygen and possesses strong oxidizing properties and causes the deleterious physiological effects (Debnath et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo

Gao

et al. 2019

Food and Agricultural Immunology

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Benzo[a]pyrene (BaP), a carcinogen, leads to the severe liver injury. Isoorientin (ISO), a natural flavonoid, is known for its bioactivities, including anti-oxidation, anti-inflammation, and so on. However, there is no report on the effects of ISO on liver injury induced by BaP. The present study demonstrated that ISO treatment could relieve BaP-caused autophagic and pyroptotic injury in HL-7702 human hepatocyte and male BALB/c mice by down-regulating the numbers of autophagosomes, the mRNA expression of LC3 II and Beclin-1, and the levels of pyroptotic characteristic indices. Histopathology stained also confirmed that ISO could suppress the BaP-induced liver injury. Meanwhile, ISO was able to improve the liver function, and remarkably (p < 0.01) ameliorate hepatic oxidative injury by enhancing antioxidant enzymes activities (T-SOD, GSH-px) and reducing the levels of MDA and H 2 O 2. In conclusion, ISO possesses the positive inhibitive effects on BaPinduced the autophagic and pyroptotic liver injury in vitro and vivo.

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Section: Discussionmentioning

confidence: 99%

Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo

Gao

et al. 2019

Food and Agricultural Immunology

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“…Oat bran found which is in the endosperm layer of oats contains several chemical constituents i.e., AVA -A and B, vanillin, and sinapic acid, and its ethanolic and water extracts are used to treat hepatic liver damage (73,104). The ethanolic extract of oats shows an inhibitory effect on oleic acid-induced hepatic steatosis invitro test (105).…”

Section: Hepatic Liver Damagementioning

confidence: 99%

Ethnobotany and Phytopharmacology of Avena sativa: A Qualitative Review

Kumari

Ali

Rahman

et al. 2023

sciphy

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Among all cereals, oat is considered to be one of the goods consumed in functional grain, nutraceutical, and pharmaceutical components. The review article aims to explore plant profile, phytochemical constituents present in different parts, and potential therapeutic agent which prevents people from different diseases with their respective mechanism of action it also includes toxicity studies, dosage form, marketed formulation, and industrial application. The information on Avena sativa is collected from the different databases available in Science Direct, PubMed, Scopus, and Google Scholar to search for research papers for literature and data. Reviewed information suggests that the A. Sativa is a good source of a range of phytochemicals including lignans, saponin, anthocyanidins, and avenanthramides, which might be directly and/or indirectly linked with beneficial nutraceutical and/or pharmacological effect(s). The review states, that A. sativa is a promising candidate as a functional and/or non-functional food because of various phytoconstituents. The clinical report has described that the utilization of oats can provide several health benefits. However, systematic rational investigations for such indications and safety profiles are yet to be explored.

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“…Similarly, Taraxacum officinale (common dandelion) is considered to have antidiabetic properties [15] and has been reported to protect against chemically induced liver toxicity in rats [16]. Avena sativa (oat) has also been described to have antiinflammatory properties [17] and can protect against LPS-induced liver injury [18].…”

Section: Introductionmentioning

confidence: 99%

The Multicomponent Medicinal Product Hepar Compositum Reduces Hepatic Inflammation and Fibrosis in a Streptozotocin- and High-Fat Diet-Induced Model of Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis

Burmeister,

Weyer,

Dörre

et al. 2023

Biomedicines

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Metabolic dysfunction-associated steatotic liver disease (MASLD)—formerly known as non-alcoholic fatty liver disease (NAFLD)—is the most common chronic liver disease worldwide. Since there is currently no approved pharmacotherapy for MASLD, there is an urgent unmet need for efficacious therapeutics for this disease. Hepar compositum (HC-24) is a multicomponent medicinal product that consists of 24 natural ingredients. It has been shown to have anti-inflammatory properties in an obesity-associated MASLD mouse model, but its potential to reduce MASLD-associated fibrosis had not been explored before this study. Here, we investigated the hepatic anti-inflammatory and anti-fibrotic potential of HC-24 in a streptozotocin (STZ)- and high-fat diet (HFD)-induced model of MASLD. Mice received a single injection of low-dose STZ at 2 days of age, followed by HFD feeding from 4 to 9 weeks of age. Mice were treated every second day with HC-24 or daily with the positive control telmisartan from 6 to 9 weeks of age. A non-diseased control group was included as a healthy reference. An explorative small-scale pilot study demonstrated that HC-24 improved liver histology, resulting in a lower NAFLD activity score and reduced liver fibrosis. A subsequent full study confirmed these effects and showed that HC-24 reduced hepatic inflammation, specifically reducing T helper cell and neutrophil influx, and decreased hepatic fibrosis (with qualitatively reduced collagen type I and type III immunopositivity) in the absence of an effect on body and liver weight, blood glucose or liver steatosis. These results show that HC-24 has hepatoprotective, anti-inflammatory, and anti-fibrotic properties in an STZ- and HFD-induced model of MASLD/MASH, suggesting that this multicomponent medicine has therapeutic potential for MASLD patients.

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Protective effect of oat ( Avena sativa ) bran extracts on acute hepatic liver damage in mice

Cited by 9 publications

References 38 publications

Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo

Isoorientin attenuates benzo[a]pyrene-induced liver injury by inhibiting autophagy and pyroptosis in vitro and vivo

Ethnobotany and Phytopharmacology of Avena sativa: A Qualitative Review

The Multicomponent Medicinal Product Hepar Compositum Reduces Hepatic Inflammation and Fibrosis in a Streptozotocin- and High-Fat Diet-Induced Model of Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis

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