Protective Effect of Nervonic Acid Against 6-Hydroxydopamine-Induced Oxidative Stress in PC-12 Cells

The Advancements and Prospects of Nervonic Acid Production

“…20 The identification of related KCS genes from NA-rich plants and the heterologous expression of these KCS genes in oil crops proved to be an effective way to achieve the increased accumulation of NA, which also provided critical information to choose efficient KCS parts to engineer oleaginous microbes. More details on enhancing the production of NA in plants by genetic engineering have been summarized in a previous review; 10 we focus on engineering oleaginous as NA-producing factories accordingly. Plant genetic engineering offers a way to modify oil crops to enhance the accumulation of NA; however, oil crop-based production has some inherent disadvantages compared with the NA production using microbes, such as slow growth rate, occupation of cultivated land, and vulnerability to climatic variability.…”

“…6−8 In addition, NA was also found in breast milk, especially in colostrum, which is critical for infant brain development. 9 An NA diet is therefore a potential therapy for neurodegenerative diseases 10 and adrenoleukodystrophy, 6 while NA-containing commercial formulas would be beneficial for infant neurodevelopment. 11,12 Yet the intake of essential lipids is not enough in the diet for sphingomyelin synthesis or the remyelination process in neuropathic individuals with a deficiency in NA.…”

“…Moreover, decreased NA levels are observed in patients with neurological diseases. , Consequently, the lack of NA will considerably raise the risk of brain diseases such as Alzheimer’s disease, stroke, Parkinson’s disease, and depression. − In addition, NA was also found in breast milk, especially in colostrum, which is critical for infant brain development . An NA diet is therefore a potential therapy for neurodegenerative diseases and adrenoleukodystrophy, while NA-containing commercial formulas would be beneficial for infant neurodevelopment. , Yet the intake of essential lipids is not enough in the diet for sphingomyelin synthesis or the remyelination process in neuropathic individuals with a deficiency in NA . NA can be readily available by the ingestion of fish or plant oils rich in NA to ameliorate neuropathy. , A recent study revealed the mechanism of cognitive improvement effects of NA .…”

Prevention of Bortezomib-Induced Peripheral Neuropathy in Newly Multiple Myeloma Patients Using Nervonic Acid, Curcuma Rizoma, and L-Arginine Compound: A Pilot Study

“…It is also implicated as an intermediate in the biosynthesis of nerve cell myelin. 19 - 21 Curcumin has been demonstrated to have a variety of biologic activities, including anti-inflammatory activities and anticancer properties. 22 , 23 L-Arginine is an α-amino acid that is used in the biosynthesis of proteins.…”

Comparison of Different Extraction Processes on the Physicochemical Properties, Nutritional Components and Antioxidant Ability of Xanthoceras sorbifolia Bunge Kernel Oil

“…In addition, C 18:2(n−6) is an essential fatty acid for the human body that lowers cholesterol, decreases blood pressure and prevents myocardial infarction [6]. X. sorbifolia kernel oil also contains a special fatty acid, nervonic acid (NA, C 24:1 ), a very long-chain monounsaturated fatty acid (MUFA) and a major fatty acid in the central nervous system that plays an important role as an antioxidant mediator in human brain cells [7]. As a component of cerebral white matter, NA helps to ensure the proper functioning of nerve fibers and nerve cells.…”