Protective Effect of Natural Antioxidant Compounds on Methimazole Induced Oxidative Stress in a Feline Kidney Epithelial Cell Line (CRFK)

Girolami, Flavia; Candellone, Alessia; Jarriyawattanachaikul, Watanya; Meineri, Giorgia; Nebbia, Carlo; Badino, P.

doi:10.3390/vetsci8100220

Cited by 4 publications

(2 citation statements)

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“…In vitro experiments with canine and feline cells have also revealed the antioxidative potential of some other plant or seed extracts. For example, quercetin is a natural occurring bioflavonoid that can increase GSH and decrease ROS in methimazole-induced oxidative stress in feline kidney epithelial cells [ 150 ]. Morin, also a flavonoid, can enhance the antioxidant capacity of hydrogen-peroxide-induced oxidative-stressed canine kidney cells by increasing the activities of SOD and CAT, and reduce mitochondrial oxidative damage and apoptosis [ 151 ].…”

Section: Dietary Strategies For Relieving Stress In Petsmentioning

confidence: 99%

Dietary Strategies for Relieving Stress in Pet Dogs and Cats

et al. 2023

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A variety of physical, emotional, and mental factors can induce a stress response in pet dogs and cats. During this process, hypothalamus–pituitary–adrenal (HPA) and sympathetic–adrenal medulla (SAM) axes are activated to produce a series of adaptive short-term reactions to the aversive situations. Meanwhile, oxidative stress is induced where there is an imbalance between the production and scavenging of reactive oxygen species (ROS). Oxidative damage is also incorporated in sustained stress response causing a series of chronic problems, such as cardiovascular and gastrointestinal diseases, immune dysfunction, and development of abnormal behaviors. In this review, the effects and mechanisms of dietary regulation strategies (e.g., antioxidants, anxiolytic agents, and probiotics) on relieving stress in pet dogs and cats are summarized and discussed. We aim to shed light on future studies in the field of pet food and nutrition.

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Section: Dietary Strategies For Relieving Stress In Petsmentioning

confidence: 99%

Dietary Strategies for Relieving Stress in Pet Dogs and Cats

et al. 2023

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“…Окислительный стресс быстро усиливается после повышения уровня гормонов щитовидной железы в периферической крови, а гипертиреоз при болезни Грейвса (БГ) связан с окислительным повреждением липидов и геномной ДНК в стенке аорты, усилением экспрессии интратиреоидного антиоксидантного белка пероксиредоксина 5 (PRDX5), повышенной активностью глутатионпероксидазы, супероксиддисмутазы и каталазы в печени [3,4]. Имеются противоречивые сообщения о том, что антитиреоидные препараты снижают уровень показателей окислительного стресса за счет восстановления эутиреоза и общего реактивного антиоксидантного потенциала плазмы [5]. Другими авторами показано снижение общей антиоксидантной способности у пациентов с БГ со средней продолжительностью гипертиреоза 2,3 ± 1,5 месяца [6].…”

Section: Introductionunclassified

The level of blood neutrophils primary reactive oxygen species production in Graves’ disease patients undergoing conservative therapy with thiamazole.

Dudina,

Dogadin,

Savchenko

et al. 2024

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Background. Conservative therapy with thiamazole in Graves’ disease helps to reduce the level of oxidative stress by restoring euthyroidism and the total reactive antioxidant potential of plasma. However, until now, in patients with Graves’ disease, the radical-producing ability of neutrophils remains unexplored at the initial stage of free radical conversion at different durations of drug-induced euthyroidism, which seems significant in revealing the mechanisms of disease recurrence. The aim is to study the level of production of primary reactive oxygen species in peripheral blood neutrophils depending on the duration of drug — induced euthyroidism in patients with Graves’ disease. Materials and methods. A single-center, prospective, controlled study was conducted with the participation of patients with laboratory-confirmed Graves’ disease. Subgroups of patients with Graves’ disease were formed depending on the duration of achieved drug-induced euthyroidism with continuous conservative therapy with thiamazole. The level of ROS production in peripheral blood neutrophils was determined by chemiluminescence. The assessment of spontaneous and zymosan-induced chemiluminescence was carried out for 90 minutes on a 36-channel chemiluminescence analyzer BLM-3607 (Medbiotech LLC, Krasnoyarsk). Results. The study included 102 Graves’ disease women with an average age of 47.54 ± 15.47 years. Of these, 75 (73.5 %) with relapse and 27 (26.47 %) with newly diagnosed disease. The total synthesis of (S) primary ROS increased statistically significantly relative to the control values in the examined patients with a duration of the euthyroid state of 5–8 and 9–12 months. It was found that in patients with Graves’ disease with stable drug-induced euthyroidism for 5–8 and 9–12 months, the S index of zymosan-induced lucigenin-dependent chemiluminescence of neutrophils increased statistically significantly, respectively, by 10.7 and 7.4 times relative to the control values. Conclusion. The restoration and maintenance of drug-induced euthyroidism for more than 12 months against the background of conservative thiamazole therapy in patients with Graves’ disease reduces the load of systemic oxidative stress on the immune system. However, the high total production of primary ROS in neutrophils of patients with Graves’ disease in a state of drug-induced euthyroidism with conservative thiamazole therapy may play a significant role in disconnecting the functioning of the NADPH oxidase complex and determine the functional capabilities of neutrophils in case of disease recurrence.

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